Membrane inlet for ion mobility spectrometry (plasma chromatography)

Spangler, Glenn E.; Carrico, John P.

doi:10.1016/0020-7381(83)85048-7

Cited by 59 publications

(31 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vapors of GD, GF, and GA were recognized as "GF", "GF," and "GA" at concentrations not lower than 0.02, 0.45, and 0.08 mg m −3 , with the marked ions of "GF-1, GF-1Low, or GD-1" (20.7-20.9 ms), "GF-1, GF-1Low, or GB-2" (20.5 ms), and "GA-1P" (19.8 ms), respectively. The K 0 [31] of GD was very close to that of GF; the vapors of both GD and GF were recognized as "GF-1" under our experimental conditions. The calibration curves for GD, GF, and GA showed similar patterns to that for GB, but the slope values for the former nerve gases were much lower than that of GB.…”

Section: Resultsmentioning

confidence: 75%

“…Two middle-height peaks at about 11 and 12 ms and one large peak at 13.5 ms, which were marked as "CAL," appeared just like those of the blank air run. The former two ion peaks (K 0 : 2.180, 1.995) could be ascribed to reagent ion peaks derived from types of protonated water-nitrogen gas clusters [31,32], while the latter CAL peak (K 0 : 1.756) was thought to be related to the calibrant molecule. The peak resolution (R) for the GB ion was calculated to be 50 (R = t/W 1/2 , where t and W 1/2 are drift time and peak width measured at half peak height, respectively).…”

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

et al. 2010

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 97%

Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

et al. 2010

View full text Add to dashboard Cite

“…[17,69] These include membrane-based inlets, [70] semi-permeable membrane inlets, spray and electro-spray, laser ablation vaporization, and thermal vaporization which is the most common technique in commercial IMS instruments. [18,71] Research instruments can be equipped with any of these inlets depending on the sample matrix and analytes of interest.…”

Section: Inletsmentioning

confidence: 99%

“…Hence the performance of a membrane-based inlet IMS can be affected by external factors such as temperature, vapor pressure of the analyte, and polarity of the membrane and the analyte. [17,70,72] Spray and electrospray inlets can be used for introducing liquid samples into the IMS analyzer. The liquid must be volatilized into gas-phase molecules and subsequently ionized.…”

Section: Inletsmentioning

confidence: 99%

“…IMS was originally referred to as plasma chromatography [70,[123][124][125][126] because ions of the chemical analytes are characterized using gas-phase ion mobility determined by the arrival times of the ion clouds. [17,126,127] The separation between ions of different sizes and/or shapes occurs while traveling along an electrostatic gradient in a drift tube at atmospheric pressure.…”

Section: Challenges Of Modeling Ion In Gas At Atmospheric Pressurementioning

confidence: 99%

See 1 more Smart Citation

The Construction and Optimization on an Ion Mobility Spectrometer for the Analysis of Explosives and Drugs

Lai¹

View full text Add to dashboard Cite

All rights reserved.iv DEDICATION I dedicate this dissertation to my family, especially to my mom and dad whom many years ago left their mother country with two pairs of empty hands, and brought their children to the land of opportunities. It is because of them that today I have the chance to study and follow my dreams. I could not be where I am today without their love, hard work, support, and sacrifice.They are my existence and my success will forever be theirs.I would like to dedicate this work to all the friends in my personal and professional network, who have always welcomed me with their kind word, kind thought, and kind heart. Last but not least, I dedicate this dissertation to my special friend Michael, who has been by my side throughout the hardest years, to whom I can share my true emotions especially in the down times. His unconditional love, support, trust, and confidence in me has helped and will continue to help me overcome many tough waves in life. Today, over 15,000 Ion Mobility Spectrometry (IMS) analyzers are employed at worldwide security checkpoints to detect explosives and illicit drugs. Current portal IMS instruments and other electronic nose technologies detect explosives and drugs by analyzing samples containing the headspace air and loose particles residing on a surface. Canines can outperform these systems at sampling and detecting the low vapor pressure explosives and drugs, such as RDX, PETN, cocaine, and MDMA, because these biological detectors target the volatile signature compounds available in the headspace rather than the non-volatile parent compounds of explosives and drugs.In this dissertation research volatile signature compounds available in the headspace over explosive and drug samples were detected using SPME as a headspace sampling tool coupled to an IMS analyzer. A Genetic Algorithm (GA) technique was developed to optimize the operating conditions of a commercial IMS (GE Itemizer 2), leading to the successful detection of plastic explosives (Detasheet, Semtex H, and C-4) and illicit drugs (cocaine, MDMA, and marijuana).Short sampling times (between 10 sec to 5 min) were adequate to extract and preconcentrate sufficient analytes (> 20 ng) representing the volatile signatures in the headspace of a 15 mL glass vial or a quart-sized can containing ≤ 1 g of the bulk explosive or drug.vii Furthermore, a research grade IMS with flexibility for changing operating conditions and physical configurations was designed and fabricated to accommodate future research into different analytes or physical configurations. The design and construction of the FIU-IMS were facilitated by computer modeling and simulation of ion's behavior within an IMS. The simulation method developed uses SIMION/SDS and was evaluated with experimental data collected using a commercial IMS (PCP Phemto Chem 110). The FIU-IMS instrument has comparable performance to the GE Itemizer 2 (average resolving power of 14, resolution of 3 between two drugs and two explosives, and LODs range from 0.7 to 9 ng).The results ...

show abstract

Membrane inlet—ion mobility spectrometry with automatic spectra evaluation as online monitoring tool for the process control of microalgae cultivation

Cämmerer

Mayer

Schott

et al. 2023

Engineering in Life Sciences

View full text Add to dashboard Cite

The cultivation of algae either in open raceway ponds or in closed bioreactors could allow the renewable production of biomass for food, pharmaceutical, cosmetic, or chemical industries. Optimal cultivation conditions are however required to ensure that the production of these compounds is both efficient and economical. Therefore, high-frequency analytical measurements are required to allow timely process control and to detect possible disturbances during algae growth. Such analytical methods are only available to a limited extent. Therefore, we introduced a method for monitoring algae release volatile organic compounds (VOCs) in the headspace above a bioreactor in real time. This method is based on ion mobility spectrometry (IMS) in combination with a membrane inlet (MI). The unique feature of IMS is that complete spectra are detected in real time instead of sum signals. These spectral patterns produced in the ion mobility spectrum were evaluated automatically via principal component analysis (PCA).The detected peak patterns are characteristic for the respective algae culture; allow the assignment of the individual growth phases and reflect the influence of experimental parameters. These results allow for the first time a continuous monitoring of the algae cultivation and thus an early detection of possible disturbances in the biotechnological process.

show abstract

Membrane inlet for ion mobility spectrometry (plasma chromatography)

Cited by 59 publications

References 18 publications

Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

The Construction and Optimization on an Ion Mobility Spectrometer for the Analysis of Explosives and Drugs

Membrane inlet—ion mobility spectrometry with automatic spectra evaluation as online monitoring tool for the process control of microalgae cultivation

Contact Info

Product

Resources

About