Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

Yamaguchi, Shintaro; Asada, Ryuji; Kishi, Shintaro; Sekioka, Ryoji; Kitagawa, Nobuyoshi; Tokita, Kenichi; Yamamoto, Soichiro; Seto, Yasuo

doi:10.1007/s11419-010-0092-z

Cited by 46 publications

(46 citation statements)

References 30 publications

(40 reference statements)

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“…The signal intensities of Au(SCN) 2 -produced in 0.1 M citrate buffer solutions at pH 5, 6-7, and 8 were 70, 100, and 90%, respectively, using octanol as the extractor, and similar results were obtained when oxalate buffer was used. When phosphate buffer was used, the best pH range was the same but the signal intensity was 50% of that of citrate buffer.…”

Section: Resultssupporting

confidence: 63%

“…Cyanide (CN -) inhibits the activity of cytochrome oxidase and is considered a chemical warfare agent [2]. According to an annual report of forensic autopsy cases in Japan, CN -is ranked among the top 20 poisonous compounds [3].…”

Section: Introductionmentioning

confidence: 99%

“…We have developed a new MS-MS method for the determination of SCN -using its chelate complex, Au(SCN) 2 -, dissolved in octanol. When Au(SCN) 2 -with m/z = 313 is used as a precursor ion, the detection of the precursor ion can be performed with a lower noise level than that of SCN -at m/z = 58 [14].…”

Section: Introductionmentioning

confidence: 99%

“…This is because noise levels from matrices usually decrease when the m/z value increases from 58 to 313. Furthermore, the extraction of Au(SCN) 2 -with octanol contributes not only to the elimination of interfering ions but also to the enhancement of ionization of Au(SCN) 2 -. Due to these improvements in selectivity and sensitivity, the present method can determine SCN -within 15 min without GC, LC, or IC separation.…”

Section: Introductionmentioning

confidence: 99%

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A rapid and decisive determination of thiocyanate in blood by electrospray ionization tandem mass spectrometry

et al. 2011

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A rapid and reliable method was developed to identify and quantify the thiocyanate ion (SCN -) in blood. SCN -was reacted with NaAuCl 4 to produce Au(SCN) 2 -, which was extracted with octanol. The extract was injected directly into an electrospray ionization tandem mass spectrometer. Quantification of SCN -was performed by selected reaction monitoring of the product ion SCN -at m/z 58 that derived from the Au(SCN) 2 -precursor ion (m/z 313). SCNcould be measured in the quantification range of 0.05-10 lM in aqueous solution with a limit of detection of 0.013 lM within 15 min. Using only 5 ll of blood, the SCN -level of a victim who ingested sodium cyanide was determined to be 32.7 ± 2.1 lM, indicating a quite small increase from the control level of 15.5 ± 8.7 lM.

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Section: Resultssupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A rapid and decisive determination of thiocyanate in blood by electrospray ionization tandem mass spectrometry

et al. 2011

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“…In suspected cases of chemical and biological terrorism, samples are first analyzed on-site and are then brought to a laboratory for detailed analysis [4]. Our laboratories have long assessed on-site detection devices and other commercially available equipment [5][6][7][8][9][10][11][12]; we have also developed new on-site detection methods for biological warfare agents [13,14].…”

Section: Introductionmentioning

confidence: 99%

Detection of saxitoxin in counterterrorism using a commercial lateral flow immunoassay kit

et al. 2010

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The neurotoxin saxitoxin (STX) is registered in the list of the Chemical Weapons Convention. In preparation against potential terrorism by STX use, we investigated the performance of a commercially available rapid test kit for paralytic shellfish poisoning (PSP), which is essentially a lateral flow immunoassay kit. Pink lines in the test and control zones appeared after 35 min and were observed by the naked eye and were recorded by a digital scanner. The competitive displacement of gold-labeled antitoxin analog antibody by STX in the test zone was quantitatively shown using the ratio of the intensity of the test zone line to that of control zone line. As the STX concentration increased, the intensity of the pink line in the test zone on the strip decreased. The limit of detection was defined as the STX concentration that gave a ratio half that of the STX blank test, and was calculated to be about 12 ng/ml. Various matrix components, such as wheat flour and the decontamination chemical hypochlorite, were examined for their effects on false positive and false negative results in the determination of STX by the PSP Rapid Test system.

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Mobile Chromatographs and Spectrometers for the Analysis of Chemical Warfare Agents

Witkiewicz¹,

Wardencki²,

Neffe³

2020

Encyclopedia of Analytical Chemistry

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This article describes the technological state of readiness regarding mobile chromatographs and spectrometers and their applicability for the analysis of chemical warfare agents (CWAs), degradation products, simulants, and precursors. Application of chromatographic techniques and instruments, which are useful for the screening and analysis of Chemical Weapons Convention (CWC)‐related chemicals, is described. Proper choice of mobile equipment and its applicability for detection of CWAs are discussed. Various miniaturized detectors and analytical procedures are described. The analytical techniques and advanced software for large amount of analytical data management are important factors when performing the on‐site analysis for security and forensic needs. The advantages and disadvantages of mobile instruments in comparison with the laboratory equipment are presented.

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Detection performance of a portable ion mobility spectrometer with 63Ni radioactive ionization for chemical warfare agents

Cited by 46 publications

References 30 publications

A rapid and decisive determination of thiocyanate in blood by electrospray ionization tandem mass spectrometry

A rapid and decisive determination of thiocyanate in blood by electrospray ionization tandem mass spectrometry

Detection of saxitoxin in counterterrorism using a commercial lateral flow immunoassay kit

Mobile Chromatographs and Spectrometers for the Analysis of Chemical Warfare Agents

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