Meltable Dextran Esters As Biocompatible and Functional Coating Materials

Abstract

The conversion of dextran with in situ synthesized iminium chlorides of long chain carboxylic acids was used to obtain pure and defined melting dextran esters in an efficient one-pot synthesis. The melting point of these esters can be tailored by the degree of substitutions (DS), the molecular weight of the starting polymer, and the chain length of the ester moiety. The dextran esters give homogeneous and completely transparent melts, which form stable films on a broad variety of materials. Even complex geometries, such as implants, can be evenly coated by multiple melting steps. The films do not display any inhomogeneity and have a very low surface roughness. Therefore, no unspecific protein binding is observed. Moreover, the dextran esters are biocompatible as demonstrated for the interaction with three types of cells namely human brain microvascular endothelial cell, primary human fibroblasts, and mouse myoblast cells.

Surface characterization and osteoblast response to a functionally graded hydroxyapatite/fluoro‐hydroxyapatite/titanium oxide coating on titanium surface by sol–gel method

“…By using the micro‐plate assay mode, measurements were taken at 620 nm and a standard curve for calculation of ALP was plotted. Measured ALP activity was finally normalized to total protein content, determined using a commercial Micro BCA protein assay kit, following Coomassie brilliant blue staining as described elsewhere .…”

Dextran Vesicular Carriers for Dual Encapsulation of Hydrophilic and Hydrophobic Molecules and Delivery into Cells

“…Therefore, suitable modification of this clinically useful polysaccharide-dextran into amphiphilic copolymers and self-organizing them as nanoscaffolds for drug delivery is much in demand 11. Earlier, a few efforts had been taken to functionalize dextran with alkyl chains or long polymers through ester or acetal linkages12 for biomedical application such as hydrogels 13. Most of these modified dextrans were found to be self-organized as nanoparticles or micelles; as a result, polysaccharide vesicles were less explored for drug delivery 14.…”

Brønsted acid-catalyzed polymerization of ε-caprolactone in water: A mild and straightforward route to poly(ε-caprolactone)-graft -water-soluble polysaccharides

“…Polyester‐ graft ‐polysaccharide copolymers are widely used in the biomedical field as drug carriers because of their biocompatibility and biodegradability combined with the ability to form supramolecular assemblies in solution . They are also known for applications as biocompatible coatings and compatibilizers for polymer blends and composite materials.…”

“…They are also known for applications as biocompatible coatings and compatibilizers for polymer blends and composite materials. For example, amphiphilic dextran esters and polyester‐ graft‐ dextran have been intensively investigated . Dextran is a synthetic water‐soluble polysaccharide whose structure consists of α(1–6) linked d ‐glucose as the main chain.…”