Surface characterization and osteoblast response to a functionally graded hydroxyapatite/fluoro‐hydroxyapatite/titanium oxide coating on titanium surface by sol–gel method

Gong, He; Guo, Bin; Wang, H.; Liang, Chao; Ye, L.; Lin, Yunfeng; Cai, Xiaoxiao

doi:10.1111/cpr.12105

Cited by 27 publications

(14 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many researchers suggested that the anatase had better bioactivity than rutile because of its apatite-forming ability and 33 34 number of hydroxyl groups. [35][36][37] In this experiment, results showed that the anatase phase formation between 400 C and 600 C agreed with previous literatures. When the annealing temperature was 400 C, the anatase XRD affrication peak was small.…”

Section: Effect Of Drying Temperature On Characterization Of Tio 2 Filmssupporting

confidence: 92%

Effects of Sol–Gel Processing Parameters on Characterization and Biological Properties of TiO<SUB>2</SUB> Films on Titanium

Zhou¹,

Gong²,

He³

et al. 2016

j nanosci nanotechnol

View full text Add to dashboard Cite

TiO 2 films were fabricated by sol-gel method, and tetraisopropoxide and c Ethoxyethanol used as precursors, respectively. The effects of sol concentration, heat processing rate, and coating thickness on characterization and osteoblastic cell response of TiO 2 films were studied by X-ray diffraction (XRD), scanning electronic microscopy (SEM), Proliferation of osteoblasts cell (MTT), and alkaline phosphatase activity. Results showed that all the sol-gel films were composed of the anatase phase. The crystallinity of TiO 2 increased with sol concentration, high concentration bringing surface defects risk. Also, the results showed that 500 C was an appropriate annealing temperature to achieve purity and larger quantity anatase phase, with lower temperature leading to the formation of anatase and higher temperature leading to the formation of rutile or other phases. Further, the results from in vitro cell response study showed that the TiO 2 films had good bioactivity and the difference in thickness had influence on the surface morphology but did not affect the biological properties of the TiO 2 films.

show abstract

Section: Effect Of Drying Temperature On Characterization Of Tio 2 Filmssupporting

confidence: 92%

Effects of Sol–Gel Processing Parameters on Characterization and Biological Properties of TiO<SUB>2</SUB> Films on Titanium

Zhou¹,

Gong²,

He³

et al. 2016

j nanosci nanotechnol

View full text Add to dashboard Cite

show abstract

“…Additionally, it is possible by MAO to obtain the formation of TiO 2 in the form of anatase and rutile . Some authors had stated that TiO 2 with structures of anatase and rutile induced the apatite formation in vitro . Kunzler et al developed a surface modification process to develop roughness gradients ranging from 1.0 to 5.7 μm on Ti surfaces.…”

Section: Discussionmentioning

confidence: 99%

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

et al. 2018

View full text Add to dashboard Cite

Highly porous Ti implant materials are being used in order to overcome the stress shielding effect on orthopedic implants. However, the lack of bioactivity on Ti surfaces is still a major concern regarding the osseointegration process. It is known that the rapid recruitment of osteoblasts in bone defects is an essential prerequisite for efficient bone repair. Conventionally, osteoblast recruitment to bone defects and subsequent bone repair has been achieved using growth factors. Thus, in this study highly porous Ti samples were processed by powder metallurgy using space holder technique followed by the bio-functionalization through microarc oxidation using a Ca- and P-rich electrolyte. The biological response in terms of early cell response, namely, adhesion, spreading, viability, and proliferation of the novel biofunctionalized highly porous Ti was carried out with NIH/3T3 fibroblasts and MC3T3-E1 preosteoblasts in terms of viability, adhesion, proliferation, and alkaline phosphatase activity. Results showed that bio-functionalization did not affect the cell viability. However, bio-functionalized highly porous Ti (22% porosity) enhanced the cell proliferation and activity. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

show abstract

“…Methods used for coating metal implants with HAp include plasma spray [297][298][299][300][301], electrophoretic deposition [302][303][304][305], pulsed laser deposition [306][307][308][309], sol-gel deposition [310][311][312][313][314], spin-coating [290], sputtering techniques [315][316][317], ion assisted deposition [296,318,319], and many other techniques such as immersion, hot pressing and hot isostatic pressing, thermal spraying and electrostatic spraying [320,321]. Plasma spraying technique is one of the most economical methods.…”

Section: Coating Of Implantsmentioning

confidence: 99%

A brief review on hydroxyapatite production and use in biomedicine

et al. 2019

View full text Add to dashboard Cite

Hydroxyapatite (HAp) is a bioceramic widely studied due to its chemical similarity with the mineral component of bones. Besides, it is biocompatible, bioactive and thermodynamically stable in the body fluid what poses it as an attractive material for a wide range of applications in the biomedical field. Several efforts have been focused on the synthesis of particles of this material aiming to the precise control of size and morphology, porosity and surface area. HAp is widely used as an implant for bone tissue regeneration, as a coating for metallic implants and in a drug-controlled release. In this sense, the objective of this review is to gather information related to HAp, providing readers with information about synthesis methods, material characteristics and their applications.

show abstract

Surface characterization and osteoblast response to a functionally graded hydroxyapatite/fluoro‐hydroxyapatite/titanium oxide coating on titanium surface by sol–gel method

Abstract: Current results indicated that the novel TiO2 /FHA/HA coating has promising clinical applications in orthopaedic and dental implantation.

Cited by 27 publications

References 42 publications

Effects of Sol–Gel Processing Parameters on Characterization and Biological Properties of TiO<SUB>2</SUB> Films on Titanium

Effects of Sol–Gel Processing Parameters on Characterization and Biological Properties of TiO<SUB>2</SUB> Films on Titanium

Influence of macroporosity on NIH/3T3 adhesion, proliferation, and osteogenic differentiation of MC3T3‐E1 over bio‐functionalized highly porous titanium implant material

A brief review on hydroxyapatite production and use in biomedicine

Contact Info

Product

Resources

About