Melt-in-Mouth Multi-particulate System for the Treatment of ADHD: A Convenient Platform for Pediatric Use

Patadia, Jalashri; Tripathi, Rahul; Joshi, Amita

doi:10.1208/s12249-015-0412-z

Cited by 9 publications

(4 citation statements)

References 22 publications

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“…Moreover, it also reduced the disintegrant property of CCS when such batches were evaluated for DT. Thus, considering these effects, its range was fixed and the risk was mitigated [22].…”

Section: Excipients Effectmentioning

confidence: 99%

Development of Tamoxifen Citrate Pellets by Hot-Melt Extrusion for Immediate Release: Study of Effect of Variables

Yadav

Kumar

2019

Int J App Pharm

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Objective: Objective of the study was to develop tamoxifen citrate immediate release pellets by hot-melt extrusion (HME) and to study the effect of various formulation and process variables. Methods: Pellets were prepared by HME technique. Effect of various parameters such as the concentration of ethylcellulose, PEG 6000, croscarmellose sodium, and spheronization speed were studied by using Central Composite Design. Pellets were evaluated for theoretical yield (%), mean pellet size (mm), sphericity (pellips), friability (%), porosity (%), mechanical crushing force (n), and dissolution efficiency. Optimized formulation was studied for compatibility study using IR, DSC, and XRD, SEM, In vitro drug release. In vitro Cell Cytotoxicity and Viability Assay were carried out using MCF-7 (human breast cancer cells) by MTT assay. Results: Results showed that a variable such as the amount of Methyl Cellulose, PEG 6000 and Spheronization speed showed positive correlation and amount of Croscarmellose sodium showed a negative correlation with dependent variables. Optimized formulation showed Korsmeyer Peppas model as a mechanism of drug release. Value of n was found to be in between 0.77+0.04, which reveals that, release mechanism of the drug as non-Fickian transport (0.45<n<0.89). MTT results of MCF-7 cells showed that optimized immediate release pellets have maximum cytotoxicity at 80 µg/ml. Conclusion: Study concluded that HME method and materials i.e. PEG 6000 and methylcellulose can effectively use to get immediate release of tamoxifen citrate so as to increase dissolution rate and cytotoxic effect.

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“…Moreover, it also reduced the disintegrant property of CCS when such batches were evaluated for DT. Thus, considering these effects, its range was fixed and the risk was mitigated [22].…”

Section: Excipients Effectmentioning

confidence: 99%

Development of Tamoxifen Citrate Pellets by Hot-Melt Extrusion for Immediate Release: Study of Effect of Variables

Yadav

Kumar

2019

Int J App Pharm

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“…The formulation of effervescent granules of MA 001 into fixed dose sachets was undertaken to address issues such as inaccurate dosing resulting from differences in volumes of household spoons used in drug administration [10,20,21], patient convenience and compliance. Patient convenience and compliance are critical for effective treatment outcomes in the management of microbial infections [22,23,24].…”

Section: Discussionmentioning

confidence: 99%

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Adi-Dako

Kumadoh

Egbi

et al. 2021

Heliyon

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Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis. The findings indicate that the effervescent granules were suitable for use in the delivery of the therapeutic constituents for the treatment of typhoid fever as done with the decoction due to minimal herbal extract-excipient interaction.

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“…The effective percentage porosity of resins after determining bulk density and true density was determined using formulae 48 where ε = effective porosity, ρt = true density and ρb = bulk density.…”

Section: Methodsmentioning

confidence: 99%

Improved therapeutic potential of tapentadol employing cationic exchange resins as carriers in neuropathic pain: evidence from pharmacokinetic and pharmacodynamics study

Sharma

Soni

2018

Sci Rep

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Current investigation was endeavoured to overcome problem of poor palatability and bioavailability of centrally acting analgesic, tapentadol (TAP) by formulating controlled release drug-resin complexes (DRCs). The technology encompassed in preparation of DRCs involved chemisorption of TAP to weak cationic resins (KyronT-134 and Tulsion335) by batch method. Various formulation variables like drug-resin ratio, pH, resin activation and swelling time were optimized to achieve maximum drug loading in DRCs. FT-IR, DSC, pXRD, in vitro release study under bio-relevant condition of mouth and in vivo sensory taste evaluation established formation of taste masked DRC whereas dissolution study assured prolonged drug release behaviour of optimized DRC. Among DRCs, TAP-KyronT-134 complex exhibited higher drug loading (80.89 ± 4.56%), stability and prolonged release profile (10 h) without any detectable amount of drug release under salivary conditions. Pharmacokinetic studies in wistar rats revealed increased Tmax (2.67-fold), MRT (1.94-fold), elimination half-life (2.79-fold) and relative oral bioavailability (2.62-fold) of TAP on oral administration of optimized formulation compared to TAP solution. Furthermore, pharmacodynamics study confessed higher potential of DRC in attenuating chronic injury induced tactile allodynia for prolonged duration. In conclusion, the method developed is easily scalable and holds potential for commercialization with an evidence of obtaining more efficacious neuropathic pain management therapy.

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Melt-in-Mouth Multi-particulate System for the Treatment of ADHD: A Convenient Platform for Pediatric Use

Cited by 9 publications

References 22 publications

Development of Tamoxifen Citrate Pellets by Hot-Melt Extrusion for Immediate Release: Study of Effect of Variables

Development of Tamoxifen Citrate Pellets by Hot-Melt Extrusion for Immediate Release: Study of Effect of Variables

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Improved therapeutic potential of tapentadol employing cationic exchange resins as carriers in neuropathic pain: evidence from pharmacokinetic and pharmacodynamics study

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