Melt Electrospinning Writing of Three-dimensional Poly(&amp;#949;-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Wunner, Felix M.; Bas, Onur; Saidy, Navid T.; Dalton, Paul D.; De‐Juan‐Pardo, Elena M.; Hutmacher, Dietmar W.

doi:10.3791/56289-v

Cited by 9 publications

(12 citation statements)

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“…Fibers were printed using a custom MEW device previously described. [33,34] Briefly, a print head with electric heating control contained a syringe that was connected to an adjustable air pressure controller (SMC, USA) and was mounted above a collector with motion controlled by two linear stages (X/Y). A high voltage source was used to generate a voltage difference between the positively charged nozzle and the grounded collector.…”

Section: Melt Electrowriting Printing Processmentioning

confidence: 99%

Magnetically Responsive Melt Electrowritten Structures

Saiz

Reizabal

Luposchainsky

et al. 2023

Adv Materials Technologies

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While melt electrowriting (MEW) can result in complex microstructures, research demonstrating such fabrication with active materials is limited. Herein, magnetoresponsive poly(𝝐-caprolactone) (PCL) inks containing up to 10 wt% of iron-oxide (Fe 3 O 4 ) nanoparticles are used to produce fiber with diameters of 9.2 ± 0.6 μm in ordered microstructures when processed by MEW. Introducing the Fe 3 O 4 nanoparticles has a minimal overall effect on printing quality compared to pure PCL under similar conditions. The magnetic response of Fe 3 O 4 containing fibers allows magnetic actuation, which is one of the first steps to control movement in such structures. Printed samples show different magnetic responses that can be controlled by the micro-and macro-structure design, the nanoparticle concentration, and multi-material design. The potential of MEW to print active magnetic complex micro-and macro-structures for 4D printing designs is demonstrated, in which active properties can be further tailored with magnetoresponsive fillers with varying characteristics and by changing MEW fiber diameters.

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Section: Melt Electrowriting Printing Processmentioning

confidence: 99%

Magnetically Responsive Melt Electrowritten Structures

Saiz

Reizabal

Luposchainsky

et al. 2023

Adv Materials Technologies

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“…MEW parameters were optimized with the coaxial system, following protocols previously identified for solid fiber fabrication. [ 26 ] A nozzle and aluminum block temperature of 80 °C, MEW was used with a shell pressure of 30 kPa, with higher shell pressures leading to a defect previously termed fiber pulsing. [ 27 ] To maintain a small air pocket within the Taylor cone, the air pressure for the inner syringe was set to 1 kPa and pulsed every 10 s for a period of 1 s—higher pressures resulted in Taylor cone rupture.…”

Section: Methodsmentioning

confidence: 99%

Hollow‐Fiber Melt Electrowriting Using a 3D‐Printed Coaxial Nozzle

et al. 2021

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Herein, a 3D-printed nozzle designed for the single-step fabrication of melt electrowritten hollow fibers is introduced. To achieve this, selective laser melting (SLM) is used to fabricate the outer part of the coaxial nozzle (800 μm inner diameter) from Ti6Al4V, into which a conventional nozzle (250 μm inner diameter) is inserted. Several iterations of coaxial nozzle design result in a wellaligned inner core nozzle that delivers air into the Taylor cone of medical-grade poly(ε-caprolactone) (PCL). Air from this bubble forms the hollow part of the fiber while the PCL shell solidifies as the shell. The smallest PCL fibers have an approximate outside diameter of 10 μm and a lumen of 6 μm, making this a promising one-step technique for small diameter hollow fiber fabrication.

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“…A higher voltage difference reduces the jet angle which results in increased CTS and reduced jet lag. [12,19] A higher CTS and reduced jet lag translate to faster prints with improved fiber placement. Even within the working range of voltage difference, an accumulation of charges may cause an electrical discharge known as arcing (Figure 3A).…”

Section: Varying Voltage Affects Fiber Diametermentioning

confidence: 99%

“…Indeed, the visualization of the jet is an important aspect of becoming proficient in MEW printer use and Table 1 directs the reader to several published examples of informative videos. With an elevated nozzle above a collector, the parabolic jet has distinct characteristics that allow monitoring, [ 12 ] real‐time fiber diameter extrapolation, [ 14 ] and even high‐throughput digitized experiments. [ 19 ]…”

Section: Modern Visualization and Manipulation Of The Mew Processmentioning

confidence: 99%

A Decade of Melt Electrowriting

O'Neill

Dalton

2023

Small Methods

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Over the past decade, melt electrowriting (MEW) has established the fundamental understanding of processing (and printer) requirements. Iterative work on parametric development and dissemination of this recent additive manufacturing technology has been performed across many systems and polymers (mainly poly-(𝝐-caprolactone)), showing similarities and trends. However, the software and hardware ecosystems of MEW are not mature. Further, due to its multi-parametric nature, MEW can be challenging for laboratories to master. This review intends to provide a unique perspective on the dynamic relationship between MEW processing parameters. Such parameters can be divided into 1) those that affect the polymer flow rate to or 2) from the nozzle, and 3) environmental conditions. The most influential parameters for high-quality printing are applied voltage, applied pressure, collector speed, polymer temperature, nozzle diameter, and the conditions that lead to charge buildup (e.g., relative humidity). Other factors such as ambient temperature, nozzle size, and protrusion, collector temperature and conductivity, and collector distance can all affect the process. Success for MEW printing means fibers fall onto the collector according to their pre-programmed path with predicted fiber diameter. Here, the authors elucidate how the dynamic relationship between these parameters can converge into ideal printing conditions to produce scaffolds.

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Melt Electrospinning Writing of Three-dimensional Poly(ε-caprolactone) Scaffolds with Controllable Morphologies for Tissue Engineering Applications

Cited by 9 publications

References 0 publications

Magnetically Responsive Melt Electrowritten Structures

Magnetically Responsive Melt Electrowritten Structures

Hollow‐Fiber Melt Electrowriting Using a 3D‐Printed Coaxial Nozzle

A Decade of Melt Electrowriting

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