Meloxicam: A toxicology overview

Lehmann, Horst; Baumeister, M.; L, Lützen; Wiegleb, J.

doi:10.1007/bf02735465

Cited by 21 publications

(11 citation statements)

References 20 publications

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“…The EDs0 established for meloxicam in this test was similar to that of indomethacin and diclofenac, but the ulcerogenicity of meloxicam is less than that of piroxicam. This was confirmed by the results of subacute and chronic toxicological studies in rats [50].…”

Section: Discussionsupporting

confidence: 78%

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

et al. 1995

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The anti-inflammatory, analgesic and antipyretic properties of the new non-steroidal anti-inflammatory agent, meloxicam, were investigated in a variety of animal models and compared with the properties of piroxicam, diclofenac, indomethacin and several other NSAIDs. With respect to the total effect of a single oral dose, the anti-exudative effect of meloxicam on carrageenan-induced oedema in the rat exceeded that of all the NSAIDs included in the comparison. Additionally, meloxicam showed the greatest potency of all the compounds examined with respect to adjuvant-induced arthritis in the rat, the granuloma pouch model and the cotton pellet test in the rat. Unlike indomethacin, in the carrageenan pleurisy model in the rat, meloxicam caused both a dose-dependent reduction in exudate volume and also inhibition of leucocyte migration. Meloxicam showed a strong and lasting effect on inflammatory pain in the rat. Like other NSAIDs, but unlike dipyrone, meloxicam had no effect in the hot plate and tail clamp tests, which are used to identify weak central analgesic effects. Unlike dipyrone and like indomethacin, meloxicam had no effect in a model of visceral distention pain. In common with other NSAIDs, meloxicam had no influence on the body temperature of normothermic rats in the anti-inflammatory dose range, but did reduce yeast-induced fever in the rat in a dose-dependent manner. Like piroxicam, meloxicam had a uricosuric effect on rats treated with oxonic acid. Low-dose meloxicam inhibited both bradykinin-induced and PAF-induced bronchospasm in the guinea-pig, but had no effect on acetylcholine-induced bronchospasm. Piroxicam had greater ulcerogenic effects in the rat stomach than meloxicam. The therapeutic range of meloxicam in the rat, with regard to inhibition of adjuvant arthritis, was several times greater than that of piroxicam, indomethacin, diclofenac and naproxen.

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Section: Discussionsupporting

confidence: 78%

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

et al. 1995

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“…The absence of statistically significant differences of the studied indicators from the reference ones indicates that the degree of toxicodynamic effect of the combination of active components [32,33] and the excipients [34] of SCS-PEO is consistent with the data reported in the literature. The results of the study on the parameters of acute toxicity indicate that SCS-PEO may be recommended for further preclinical study of specific prostate protective action, as significant toxic effects with single administration at doses exceeding the proposed therapeutic 3-4 times, were not detected.…”

Section: Discussion Of the Resultssupporting

confidence: 88%

Experimental Study of Antimicrobial Properties and Acute Toxicity of the Peo-Based Combined Suppositories

Ravshanov

Zaychenko

Zhemerova³

et al. 2019

EUREKA: Health Sciences

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Aim. The research of antimicrobial and toxicological parameters of a promising pharmaceutical composition with indole-3-carbinol and meloxicam in the form of rectal suppositories. Materials and methods. The research of antimicrobial activity was carried out in vitro by diffusion in nutrient agar in the modification of "holes" on the reference strains of common pathogens Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Candida albicans. Adult rats were used for the study of acute toxicity. Suppository mass were administrated in the largest possible volume rectally or orally. The animals were periodically monitored according to the experimental plan – the assessment of physiological parameters before administration and after 6, 12, 18, 24 hours, at 3, 7 and 14 days. The animals were removed from experiment and necropsy provided after 1, 3, 7, and 14 days. Results. The sizes of zones of inhibition of the microorganisms growth were most significant (from 19.27±0.61 mm of E. coli to 40.80±0.42 mm of S. aureus) near sample of the combined composition suppository compared with other combination of active substances and excipients. During the observation of animals for 14 days and the study of internal organs after autopsy, deviations in physiological (weight, temperature, activity, respiratory rate) and macroscopic morphological indicators of animals from reference values were not detected. Conclusion. According to the results of microbiological studies, a moderate antimicrobial effect of suppositories of combined composition in relation to all the studied pathogens was revealed. The absence of manifestations of acute toxicity allows us to conclude that the pharmaceutical composition can be classified as practically non-toxic substances. The obtained results allow us to recommend a pharmaceutical composition with indole-3-carbinol and meloxicam on a polyethylene oxide basis in the form of suppositories for further preclinical studies of specific pharmacological effects as a prostate protective agent.

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“…Studies evaluating meloxicam in ruminant species have been performed, but the reports refer only to pharmacokinetic data and do not include assessments of toxicity according to clinical signs, clinical pathology, or histopathology. 20,33,34 Toxicologic overviews of meloxicam have been described for several other species, 24,27 but to our knowledge, specific studies establishing toxic dose ranges for meloxicam in sheep are unavailable. In a published toxicology study of horses, oral administration of meloxicam at 3 to 5 times the recommended dose given daily over 2 wk was associated most commonly with gastrointestinal conditions and only one episode of renal damage.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Evaluation of Sustained-release Compared with Conventional Formulations of Meloxicam in Sheep (Ovis aries)

Dunbar

Walkowiak

Faustich

et al. 2019

j am assoc lab anim sci

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Sustained-release (SR) drugs refine current analgesic regimens by alleviating the need for multiple sessions of handling and restraint and by reducing the local tissue irritation that can occur due to repeated injections. Although a variety of SR drugs are already used in lab animal medicine, no studies exist that evaluate the suitability of an SR NSAID in sheep. This study used HPLC-MS to measure the plasma concentrations of 2 formulations of meloxicam-conventional and SRMafter subcutaneous administration in 6 adult ewes. Blood was collected at 0,

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Meloxicam: A toxicology overview

Cited by 21 publications

References 20 publications

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

Experimental Study of Antimicrobial Properties and Acute Toxicity of the Peo-Based Combined Suppositories

Preliminary Evaluation of Sustained-release Compared with Conventional Formulations of Meloxicam in Sheep (Ovis aries)

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