Melioidosis of the Head and Neck: A Case Series from Eastern India

Mohanty, Srujana; Sarkar, Saurav; Mishra, Baijayantimala

doi:10.3390/idr12030011

Cited by 5 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improvement in diagnostic facilities has led to the detection of more cases of melioidosis along the states of coastal belts like Karnataka, Kerala, and Tamil Nadu, but it is not limited to that region. Studies conducted in Odisha conclude that there is a major hidden focus of melioidosis in Odisha [3][4]. Our case reports corroborate with these studies and throw light on the…”

Section: Introductionsupporting

confidence: 88%

See 1 more Smart Citation

Solid Organ Abscess by Melioidosis: An Emerging Infection Among Diabetics in Odisha, India

Dash¹,

Prusty²,

Pattnaik³

et al. 2022

Cureus

View full text Add to dashboard Cite

Melioidosis is an infection in tropical regions, caused by Gram-negative bacillus Burkholderia pseudomallei and carries very high case fatality rates. Diabetes mellitus is a major risk factor for melioidosis, and Odisha with its current trends in urban prevalence of diabetes and a tropical coastal climate seems to be emerging as a hub of melioidosis.We herein describe two cases of melioidosis encountered within a month. Case 1 is a 35-year-old male recently diagnosed with diabetes, presenting with fever and altered sensorium for 5 days. Case 2 is a 40year-old female who complained of fever, cough, and generalised weakness for 2 months, and was subsequently found to be diabetic on routine investigations. Both the patients were subjected to imaging modalities which showed solid organ (liver and spleen) abscesses. On further investigations, Burkholderia pseudomallei was isolated from their blood cultures.Diagnosis of such cases within a short period of time points to the fact that Odisha indeed serves as a hidden hotspot of melioidosis. The case report throws light on the importance of early diagnosis and treatment of melioidosis, which is under-reported in the state, and it also aims to impress upon physicians to have a strong clinical suspicion so as to decrease the mortality associated this neglected tropical disease.

show abstract

Section: Introductionsupporting

confidence: 88%

“…The disease has a mortality rate reaching as high as 95% in untreated cases and a rate of 50% even after treatment with antibiotic therapy. The commonly used antibiotic regimen consists of parenteral ceftazidime as intensive therapy followed by oral trimethoprim-sulfamethoxazole as maintenance therapy [3].…”

Section: Introductionmentioning

confidence: 99%

Solid Organ Abscess by Melioidosis: An Emerging Infection Among Diabetics in Odisha, India

Dash¹,

Prusty²,

Pattnaik³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…pseudomallei infection can be acute, chronic, or latent, leading to recurrent infection after a period of time. Melioidosis can occur in any range of age [7]. It can hide inside macrophages and produce many kinds of virulence factors.…”

Section: Introductionmentioning

confidence: 99%

Diversity of Colony Morphotypes, Biochemical Characteristics, and Drug Susceptibility Patterns of Burkholderia pseudomallei Isolated from Humans, Animals, and Environmental Sources in Thailand

et al. 2022

View full text Add to dashboard Cite

Melioidosis is an infection that occurs in humans and a wide range of animals by Burkholderia pseudomallei as a causative pathogen, which inhabits environments of tropical and subtropical climate zones, particularly in Thailand. The standard laboratory diagnosis is by culture and biochemical characteristic differentiation. This study aimed to determine the diversity of colony morphology, biochemical characteristics, and drug susceptibility patterns of a B. pseudomallei collection isolated from humans, animals, soil, and water in Thailand. According to the previous characterization of colony morphotypes from Type I to VII, Type I is predominant with B. pseudomallei from humans and animals with a similar water source. Meanwhile, Type III is predominant from soil sources. The results confirmed the hypothesis that infection might be from water instead of soil exposure. The typical biochemical phenotypes were consistent among different isolate sources, including cytochrome oxidase (positive), triple iron sugar (K/N or A/N), sulfide (negative), indole (negative), non-motile, glucose oxidizing, and DNase (positive). The biochemical characteristic results supported the data for the selection of the prepopulated biochemical tests in clinical and research laboratories. The antimicrobial susceptibility patterns by standard disk diffusion showed mode values of inhibition zones for selected drugs that had lower trends in B. pseudomallei isolated from the soil than other sources. The results were consistent with MIC50 and MIC90 values of ceftazidime, which was highest in B. pseudomallei from the soil than other sources. HIGHLIGHTS The previous study reported the characterization of Burkholderia pseudomallei colony morphotypes from Type I to VII. However, there were no reports of the diversity of colony morphology and antibiotic susceptibility pattern from diverse sources Type I is predominant with B. pseudomallei from humans and animals with a similar water source, which confirmed the hypothesis that infection might be from water instead of soil exposure The mode of antimicrobial inhibition zones for selected drugs had lower trends in the isolates from the soil than other sources. The results indicated the soil isolates showed a trend in increasing ceftazidime resistance compared with other sources GRAPHICAL ABSTRACT

show abstract

“…However, he was a resident of a TB endemic zone and a farmer by occupation, which made him prone to melioidosis, which is common in irrigated areas such as rice paddies 6 . There are few cases of melioidosis reported from our state earlier 9,18,21,22 .…”

Section: Discussionmentioning

confidence: 93%

Coinfection of Melioidosis and Tuberculosis Causing Infective Lumbar Spondylodiscitis

Jain

Ratna

Mohanty

et al. 2023

JBJS Case Connector

Self Cite

View full text Add to dashboard Cite

Case: A 63-year-old farmer who is a known diabetic and chronic alcoholic presented with lower back pain and neurological weakness of lower limbs present for the past 3 months. His acute phase reactants were very high, and magnetic resonance imaging displayed L4-L5 vertebral involvement with epidural, paravertebral, and bilateral psoas abscesses. Cultures of an ultrasound-guided aspiration from the psoas were positive for Burkholderia pseudomallei, and a nucleic acid amplification test also detected Mycobacterium tuberculosis. He underwent posterior decompression and fixation, and intraoperative biopsy confirmed a granulomatous reaction. He received appropriate antibiotics for both diseases. At 1 year, he showed healing on radiographic imaging, with independent ambulation status. Conclusion:The coexistence of melioidosis and tuberculosis is rare, and as far as we know, a case of infective spondylodiscitis has not been reported. In patients with infective spondylodiscitis, every attempt should be made to confirm the diagnosis before starting empirical antitubercular treatment (ATT).Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSCC/C91).

show abstract

Melioidosis of the Head and Neck: A Case Series from Eastern India

Cited by 5 publications

References 17 publications

Solid Organ Abscess by Melioidosis: An Emerging Infection Among Diabetics in Odisha, India

Solid Organ Abscess by Melioidosis: An Emerging Infection Among Diabetics in Odisha, India

Diversity of Colony Morphotypes, Biochemical Characteristics, and Drug Susceptibility Patterns of Burkholderia pseudomallei Isolated from Humans, Animals, and Environmental Sources in Thailand

Coinfection of Melioidosis and Tuberculosis Causing Infective Lumbar Spondylodiscitis

Contact Info

Product

Resources

About