Melioidosis and tuberculosis: dual pathogens in a neck abscess

Shenoy, Srinivas Vinayak; Kamath, M. Panduranga; Hegde, Mahesh Chandra; D’souza, Trina Lucille; Mammen, S. S.

doi:10.1017/s0022215109004460

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Diagnostic confusion with tuberculosis can occur, especially as the ethnic groups with a high incidence of both diseases are similar [16]. Incidentally, co-infection of B. pseudomallei with Mycobacterium tuberculosis has also been described on few occasions [17,18].…”

Section: Discussionmentioning

confidence: 99%

Melioidosis of the Head and Neck: A Case Series from Eastern India

Mohanty

Sarkar

Mishra

2020

Infectious Disease Reports

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Melioidosis is an emerging entity in India. Though it is a potentially fatal disease, prognosis is excellent with early detection and appropriate management, especially of localized infections like abscesses of the head and neck area. We report nine cases of focal abscesses in the head and neck region due to Burkholderia pseudomallei, the causative agent of melioidosis, presenting to our hospital within a span of two-and-half years. Since melioidotic abscesses in the cervicofacial and head and neck region are likely to be confused with cold abscesses caused by Mycobacterium tuberculosis in a tuberculosis-endemic country like India, increased vigilance is necessary because of the widely divergent treatment modalities of the two disease entities.

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Section: Discussionmentioning

confidence: 99%

Melioidosis of the Head and Neck: A Case Series from Eastern India

Mohanty

Sarkar

Mishra

2020

Infectious Disease Reports

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“…Bone and Joint Infection (BJI) caused by B. pseudomallei, including septic arthritis and osteomyelitis, is a rare but potentially severe infection which might end with bleak outcomes (Raja and Scarsbrook, 2016). Melioidosis lacks definite clinical symptoms with many of them shared similar manifestations with pyogenic bacterial infection and tuberculosis infection, making the diagnose of melioidosis challenging (Shenoy et al, 2009;Doker et al, 2014;Garg et al, 2020). The same is true for melioidotic osteomyelitis and septic arthritis.…”

Section: Introductionmentioning

confidence: 99%

Osteomyelitis and Septic Arthritis Due to Burkholderia pseudomallei: A 10-Year Retrospective Melioidosis Study From South China

Wang

Zhou

et al. 2021

Front. Cell. Infect. Microbiol.

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Burkholderia pseudomallei is the causative agent of melioidosis, endemic mainly in tropical and subtropical areas. Its clinical manifestation is broad ranging from a localized skin lesion to a life-threatening systemic disease. Osteomyelitis and septic arthritis caused by B. pseudomallei are a rare, fatal illness, whose clinical features have not been illustrated in mainland China. Over 10 years (2010 to 2019), of 334 culture-confirmed melioidosis in Hainan province, China, 44 patients (13.2%) were confirmed to have osteomyelitis and septic arthritis through the combination of clinical features, imaging examination and microbiological culture. Herein, we summarized these 44 patients’ clinical manifestations, demographical features, antibiotic treatment, and outcomes. Of them, osteomyelitis and septic arthritis accounted for 25 (56.8%) and 15 (34.1%), respectively, and 4 patients (9.1%) had both. The gender ratio of male/female was approximately 13.7:1; diabetes mellitus was the most common risk factor (38/44, 86.4%); imipenem and trimethoprim/sulfamethoxazole were the most frequently used antibiotics. Most B. pseudomallei strains were isolated from blood samples (41/44, 93.2%). After surgical handling, antibiotic treatment, or both, 9 patients died, with a mortality rate of 20.5%. In summary, in melioidosis endemic areas, for patients with both localized manifestations of joint and bone and a positive B. pseudomallei blood culture, increased awareness is required for melioidotic osteomyelitis and septic arthritis.

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“…Annually, an average of 227 TB cases were recorded in Brunei Darussalam of awareness of these coinfections. [5][6][7][8][9][10][11][12][13][14] This report documents a case of coinfection with pulmonary TB (PTB) and melioidosis in a patient with poorly controlled DM in Brunei Darussalam.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary tuberculosis and melioidosis coinfection in Brunei Darussalam: the importance of awareness and screening

Rubel

Mani

Kishore

et al. 2022

WPSAR

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Both tuberculosis (TB) and melioidosis are endemic to certain parts of the world, including Brunei Darussalam, with TB being more widespread. Despite this, coinfection with TB and melioidosis is rarely encountered and reported. Although still uncommon, there has been an increase in the number of cases of this coinfection reported during the past 10 years, all of which have been in India and the World Health Organization’s Western Pacific Region. We report a case of coinfection with pulmonary TB and melioidosis in a patient with poorly controlled diabetes mellitus. This 64-year-old man presented with symptoms and radiological features of pulmonary TB, confirmed by sputum smear, but sputum culture also yielded Burkholderia pseudomallei, the pathogen that causes melioidosis. Coinfection was detected due to our practice of routinely screening for other infections in patients suspected or confirmed to have pulmonary TB. This highlights the importance of awareness of melioidosis and the need to consider screening for infection, especially in endemic regions.

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Melioidosis and tuberculosis: dual pathogens in a neck abscess

Abstract: Increased awareness of melioidosis is important as, although the organism is easy to culture, it may be dismissed as a contaminant.

Cited by 11 publications

References 9 publications

Melioidosis of the Head and Neck: A Case Series from Eastern India

Melioidosis of the Head and Neck: A Case Series from Eastern India

Osteomyelitis and Septic Arthritis Due to Burkholderia pseudomallei: A 10-Year Retrospective Melioidosis Study From South China

Pulmonary tuberculosis and melioidosis coinfection in Brunei Darussalam: the importance of awareness and screening

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