Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet

Szewczyk-Golec, Karolina; Rajewski, Paweł; Gackowski, Marcin; Mila-Kierzenkowska, Celestyna; Wesołowski, Roland; Sutkowy, Paweł; Pawłowska, Marta; Woźniak, Alina

doi:10.1155/2017/8494107

Cited by 71 publications

(62 citation statements)

References 98 publications

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“…Melatonin administration has been correlated to the enhancement of the plasmatic antioxidant capacity in both animal models and human studies [77]. In general, melatonin intake is associated with diminished oxidative stress [78]. The supplementation with melatonin can be beneficial, beyond oxidative stress, in the reduction of inflammation, hypertension, and other metabolic syndrome-related markers [77].…”

Section: Administration Of Lentil Sprouts Enhances Plasmatic Antioxidmentioning

confidence: 99%

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

Rebollo‐Hernanz

Aguilera

Herrera

et al. 2020

Foods

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Melatonin is a multifunctional antioxidant neurohormone found in plant foods such as lentil sprouts. We aim to evaluate the effect of lentil sprout intake on the plasmatic levels of melatonin and metabolically related compounds (plasmatic serotonin and urinary 6-sulfatoxymelatonin), total phenolic compounds, and plasmatic antioxidant status, and compare it with synthetic melatonin. The germination of lentils increases the content of melatonin. However, the phenolic content diminished due to the loss of phenolic acids and flavan-3-ols. The flavonol content remained unaltered, being the main phenolic family in lentil sprouts, primarily composed of kaempferol glycosides. Sprague Dawley rats were used to investigate the pharmacokinetic profile of melatonin after oral administration of a lentil sprout extract and to evaluate plasma and urine melatonin and related biomarkers and antioxidant capacity. Melatonin showed maximum concentration (45.4 pg/mL) 90 min after lentil sprout administration. The plasmatic melatonin levels increased after lentil sprout intake (70%, p < 0.05) with respect to the control, 1.2-fold more than after synthetic melatonin ingestion. These increments correlated with urinary 6-sulfatoxymelatonin content (p < 0.05), a key biomarker of plasmatic melatonin. Nonetheless, the phenolic compound content did not exhibit any significant variation. Plasmatic antioxidant status increased in the antioxidant capacity upon both lentil sprout and synthetic melatonin administration. For the first time, we investigated the bioavailability of melatonin from lentil sprouts and its role in plasmatic antioxidant status. We concluded that their intake could increase melatonin plasmatic concentration and attenuate plasmatic oxidative stress.

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Section: Administration Of Lentil Sprouts Enhances Plasmatic Antioxidmentioning

confidence: 99%

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

Rebollo‐Hernanz

Aguilera

Herrera

et al. 2020

Foods

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“…Pineal melatonin synthesis/secretion is stimulated by darkness and inhibited by exposure to light [12]. Intervention studies reported that melatonin can improve lipid profile [13], glycemic status [14], immune system function [15], anti-oxidative status [16], and inflammatory parameters [17]. In addition, some studies introduced melatonin as a potential BP regulator [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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Melatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta—analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potential RCTs with information on melatonin supplementation and BP. Mean Differences (MD) were pooled using a random-effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Pooling 5 RCTs (6 treatment arms) together identified significant reduction for SBP (MD: −3.43 mmHg, 95% confidence interval (CI): −5.76 to −1.09, p=0.004) and DBP (MD: −3.33 mmHg, 95% CI: −4.57 to −2.08, p<0.001) after supplementation with melatonin compared with control treatment. The sensitivity analysis indicated that the results were robust. We did not observe any evidence regarding publication bias. The findings of this meta-analysis support the overall favorable effect of melatonin supplementation on BP regulation.

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“…<30-50 lux). 21 This nocturnal hormone is known for impacting seasonal and circadian rhythms, 22 promoting sleep onset, influencing core body temperature (CBT), and following a 24-hour light-dark cycle. 17 In particular, the enzymes involved in synthesizing melatonin are stimulated by darkness and inhibited by light.…”

Section: Melatoninmentioning

confidence: 99%

Menstrual Cycle Fluctuations of Progesterone and the Effect on Sleep Regulation

Cherpak

Lare

2019

JRM

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Women of reproductive age experience higher rates of sleep disturbance than their male counterparts, leading to lack of restorative sleep and increasing risk for chronic disease. The objective of this review is to overlay the menstrual cycle with sleep regulation to develop an evidence-based theoretical model that directs clinical interventions for improved sleep in affected women. Utilizing the basic mechanisms for sleep and the menstrual cycle, in addition to evidence for sleep and hormonal dysregulation, hormonal fluctuations are mapped to variations in gamma-aminobutyric acid (GABA), melatonin, and cortisol levels. Effective interventions that may be included in individualized treatment plans – varying based on the scope of practice for each practitioner – are presented, along with the impetus for future research to explore the relationship between the menstrual cycle and sleep regulation.

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Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet

Cited by 71 publications

References 98 publications

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Menstrual Cycle Fluctuations of Progesterone and the Effect on Sleep Regulation

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