Melatonin Regulates the Neurotransmitter Secretion Disorder Induced by Caffeine Through the Microbiota-Gut-Brain Axis in Zebrafish (Danio rerio)

Zeng, Zhen; Peng, Qingyun; Huo, Dongxue; Jiang, Shuaiming; Ma, Chenchen; Chang, Haibo; Chen, Kaining; Li, Congfa; Yingjie, Pan; Zhang, Jiachao

doi:10.3389/fcell.2021.678190

Cited by 17 publications

(18 citation statements)

References 51 publications

(56 reference statements)

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“…30 A GF zebrafish study revealed a potential mode of action where melatonin could regulate disorders of neurotransmitter secretion induced by caffeine via the gut-microbiome-brain axis. 31 Additionally, Cuomo et al documented that the administration of L.…”

Section: The Gut-brain Axismentioning

confidence: 99%

“… 30 A GF zebrafish study revealed a potential mode of action where melatonin could regulate disorders of neurotransmitter secretion induced by caffeine via the gut‐microbiome‐brain axis. 31 Additionally, Cuomo et al documented that the administration of L. rhamnosus in larvae led to DNA methylation code of the Tph1A and BDNF promoter gene reconstruction in the gut and the brain of zebrafish. Accordingly, alterations in the gut microbiome may influence the host epigenetic landscape, resulting in long‐term consequences for specific gene regions.…”

Section: The Roles Of the Gut Microbiome In Tissue Development And Ph...mentioning

confidence: 99%

“…In this respect, zebrafish’s social and explorative behavior could be significantly altered; the expression levels of endogenous neuroactive molecules, brain‐derived neurotrophic factor, and serotonin were modulated to a certain extent by feeding with probiotic L. rhamnosus 30 . A GF zebrafish study revealed a potential mode of action where melatonin could regulate disorders of neurotransmitter secretion induced by caffeine via the gut‐microbiome‐brain axis 31 . Additionally, Cuomo et al documented that the administration of L. rhamnosus in larvae led to DNA methylation code of the Tph1A and BDNF promoter gene reconstruction in the gut and the brain of zebrafish.…”

Section: The Roles Of the Gut Microbiome In Tissue Development And Ph...mentioning

confidence: 99%

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Application of zebrafish in the study of the gut microbiome

Zhong

et al. 2022

Anim Models and Exp Med

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The gut microbiome is widely acknowledged to coexist with the animal host, consisting of symbiotic and pathogenic bacteria in a dynamic balance state that produce a wide variety of signaling molecules. These bacteria colonize the intestine and perform functions the host itself cannot accomplish; in turn, they rely on the habitat provided by the host. A healthy gut microbiome plays a significant and irreplaceable role in determining the host's overall health.Zebrafish is an omnivorous freshwater fish that belongs to the small carp family. It has been widely used for research purposes on embryology and tissue regeneration, molecular genetics, reproductive biology, and toxicology given its numerous advantages, including high fecundity, short lifespan, highly annotated genome, optical

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Section: The Gut-brain Axismentioning

confidence: 99%

Section: The Roles Of the Gut Microbiome In Tissue Development And Ph...mentioning

confidence: 99%

Section: The Roles Of the Gut Microbiome In Tissue Development And Ph...mentioning

confidence: 99%

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Application of zebrafish in the study of the gut microbiome

Zhong

et al. 2022

Anim Models and Exp Med

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“…In glyphosatetreated Chinese mitten crab (Eriocheir sinensis), the supply of MEL (80 mg/kg food) as a supplement to the standard feed for 14 days significantly increases the relative abundance and Shannon index of Proteobacteria and Bacteroidete along with an enhanced activity of amylase, lipase, and trypsin in the gut (Song et al, 2020). Further, in zebra fish (D. rerio), 1 µM MEL administration in filtered tank water for 14 days improves metabolism and normal gut microbial homeostasis, and restores neurotransmitter release (Zhang et al, 2021). Bacillus, Lactobacillus, and Escherichia coli constitute the major microbial populations in fish gut and significantly improve various physiological activities during the rearing of fish in aquaculture practice (Carnevali et al, 2004;Hasan and Banerjee, 2020).…”

Section: Impact Of Melatonin On Microbiota In Fish Gutmentioning

confidence: 99%

“…The impact of MEL on fish growth and development in association with digestive physiology are also evident from several studies (Falcón et al, 2003(Falcón et al, , 2007(Falcón et al, , 2010Pal et al, 2016a;Pal and Maitra, 2018). Several lines of evidence suggest that MEL, along with its effect on enhancing the digestive enzyme activity in the gut, has a significant impact on the gut microbiota in fish as well as in other vertebrates (Yin et al, 2018(Yin et al, , 2020Wang et al, 2021;Zhang et al, 2021). A fish study by evincing a role of endogenous MEL in ameliorating microbial infection-induced pathogenesis implicates MEL in aquaculture against ulcer causative agents (Pal et al, 2016b).…”

Section: Introductionmentioning

confidence: 97%

Melatonin as a Multipotent Component of Fish Feed: Basic Information for Its Potential Application in Aquaculture

2021

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In vertebrates, melatonin (N-acetyl-5-methoxy-tryptamine, MEL) is synthesized from L-tryptophan (L-Trp), primarily in the pineal gland and additionally in several non-pineal tissues, including enterochromaffin cells of the gastrointestinal tract. The biosynthesis of MEL in the pinealocytes exhibits a daily rhythm with a nocturnal peak in synchronization with the dark phase of an environment. However, the temporal pattern of the gut melatoninergic system in fish is known to be synchronized with one or more non-photic external cue(s), of which most notable include the components of food and feeding time in a daily cycle. Experimental findings on the use of L-Trp (5-fold to −8-fold higher with respect to standard) as a fish food supplement suggest that it has a stimulatory influence on gut MEL synthesis that ultimately leads to elevated levels of plasma MEL. Several studies employing MEL as a fish feed additive report variable responses in relation to the physiological functions of the fish and its doses of application and modes of exposure. Oral administration of MEL (validated dose in general: 200 mg/kg fish food) causes an increase in gut MEL concentrations, food intake capacity, and micronutrient selection ability of fish, as well as enhanced activity of antioxidative enzymes and/or reduced levels of biological stress markers like plasma cortisol and lactate. The application of MEL with the doses of 50 and 250 mg/kg fish food to balanced diet results in precious maturation of gonads, high live sperm rate, and good quality seeds in catfish. A few studies on different fish groups administered with MEL through tank water reveal a significant increase in the fecundity rate, percentage of fertilization, and the number of hatched embryos. MEL injection through intraperitoneal or intramuscular routes also elicits variable responses in fish. Several studies suggest a major protective role of endogenous MEL against gastric ulcer induced by pathogenic bacterial infection. Taken together, MEL seems to be a multipotent physiological candidate involved in the regulation of a variety of body functions ranging from the synchronization of vital activities with environmental variables to the timing of reproduction in a changing system, from the acceleration of body growth to the determination of a pattern of development, and from the reduction of oxidative stress to the protection against microbial infections. Because aquaculture aims at substantially improving the quality and quantity of available aquatic resources employing convenient, consistent, and commercially exploitable measures, we find the reasons to suggest that the use of MEL or its precursor L-Trp as a fish food supplement may open up a new vista of aquaculture and, hence, present this review with an attempt to present the basic information on this area of interest to justify the hypothesis.

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