Melatonin reduces lipid and protein oxidative damage in synaptosomes due to aluminium

Calleja, Carlos David Albendea; Gómez-Trullén, Eva M; Fuentes-Broto, Lorena; Miana-Mena, Francisco Javier; Millán-Plano, Sergio; Reyes-Gonzales, Marcos César; Martı́nez-Balları́n, Enrique; García, Joaquín J.

doi:10.1016/j.jtemb.2007.04.002

Cited by 37 publications

(24 citation statements)

References 53 publications

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“…In this study, basal levels of LPx products measured as malondialdehyde (MDA) were found to be significantly increased after Al exposure in both the cerebrum and cerebellum (Table 4). Similar results were also observed in various laboratories after Al treatment to experimental animals (Dua and Gill 2001;Kaiser et al 2005;Nehru et al 2007;Albendea et al 2007). It is known that Al is a nonredox active metal (Zatta et al 2002), therefore cannot participate directly in oxidation.…”

Section: Discussionsupporting

confidence: 88%

Protective Role of Lithium in Ameliorating the Aluminium-induced Oxidative Stress and Histological Changes in Rat Brain

Bhalla¹,

Dhawan²

2009

Cell Mol Neurobiol

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This study was carried out to investigate the effects of lithium (Li) supplementation on aluminium (Al) induced changes in antioxidant defence system and histoarchitecture of cerebrum and cerebellum in rats. Al was administered in the form of aluminium chloride (100 mg/kg b.wt./day, orally) and Li was given in the form of Li carbonate through diet (1.1 g/kg diet, daily) for a period of 2 months. Al treatment significantly enhanced the levels of lipid peroxidation and reactive oxygen species in both the cerebrum and cerebellum, which however were decreased following Li supplementation. The enzyme activities of catalase, superoxide dismutase (SOD) and glutathione reductase (GR) were significantly increased in both the regions following Al treatment. Li administration to Al-fed rats decreased the SOD, catalase and GR enzyme activities in both the regions; however, in cerebellum the enzyme activities were decreased in comparison to normal controls also. Further, the specific activity of glutathione-s-transferase and the levels of total and oxidized glutathione were significantly decreased in cerebrum and cerebellum following Al treatment, which however showed elevation upon Li supplementation. The levels of reduced glutathione were significantly decreased in cerebrum but increased in cerebellum following Al treatment, which however were normalized upon Li supplementation but in cerebellum only. Apart from the biochemical changes, disorganization in the layers of cerebrum and vacuolar spaces were also observed following Al treatment indicating the structural damage. Similarly, the loss of purkinje cells was also evident in cerebellum. Li supplementation resulted in an appreciable improvement in the histoarchitecture of both the regions. Therefore, the study shows that Li has a potential to exhibit neuroprotective role in conditions of Al-induced oxidative stress and be explored further to be treated as a promising drug against neurotoxicity.

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Section: Discussionsupporting

confidence: 88%

Protective Role of Lithium in Ameliorating the Aluminium-induced Oxidative Stress and Histological Changes in Rat Brain

Bhalla¹,

Dhawan²

2009

Cell Mol Neurobiol

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“…Also, melatonin has the ability to serve as a metal chelator to reduce metal toxicity [31]. Melatonin stabilizes membranes against free radicals and can resist the rigidity of the biological membranes caused by Al [32]. Moreover, Yang et al [6] reported that melatonin effectively reduces lipid peroxidation induced by Al in Alzheimer's patients.…”

Section: Discussionmentioning

confidence: 99%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl 3 to induce AD and ADinduced rats treated with melatonin. Hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

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“…Al and its salts are commonly used in various daily applications, such as water treatment, wood preservation, food additives, toothpastes, antiperspirants, shampoos, vitamins, medications, vaccines, antacids, phosphate binders, buffered aspirin products, packaging materials, or as fillers in plastics (Yokel and McNamara, 2001;Becaria et al, 2002;Nayak, 2002;Yenigül, 2006). In the literature, Al has been shown to have a toxic effect on several tissues and organs such as the brain, liver, kidneys, testicles, stomach, parathyroid gland, intestines, and blood tissue (Albendea et al, 2007;Krewski et al, 2007;Turgut et al, 2007;Amer, 2008;Bogdanovic et al, 2008;Abdel Moneim et al, 2013). In particular, aluminum sulfate (Al 2 (SO 4 ) 3 ) has been shown to cause toxicity to the liver, kidneys, and nervous system in laboratory animals (Material Safety Data Sheet LA1407 Al 2 (SO 4 ) 3 ; Schetinger et al, 1999;Gawish, 2005).…”

Section: Introductionmentioning

confidence: 99%

Melatonin is a potent modulator of antioxidative defense and cellular proliferation against aluminum toxicity in rats

Bulan¹,

Sarikaya-Unal²,

Tunalı³

et al. 2015

Turk J Biol

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Melatonin reduces lipid and protein oxidative damage in synaptosomes due to aluminium

Cited by 37 publications

References 53 publications

Protective Role of Lithium in Ameliorating the Aluminium-induced Oxidative Stress and Histological Changes in Rat Brain

Protective Role of Lithium in Ameliorating the Aluminium-induced Oxidative Stress and Histological Changes in Rat Brain

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Melatonin is a potent modulator of antioxidative defense and cellular proliferation against aluminum toxicity in rats

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