Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats

Rosa, Darlan Pase da; Bona, Silvia Regina; Simonetto, Douglas A.; Zettler, Cláudio Galeano; Marroni, Cláudio Augusto; Marroni, Norma Possa

doi:10.1590/s0004-28032010000100013

Cited by 29 publications

(26 citation statements)

References 43 publications

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“…39,58,61,62,63 The massive disarrangement of hepatic tissues architecture of untreated fibrotic rats (Group 3) correlated with the levels of alterations of serum indicators, namely, serum ALT, AST and ALP activities as well as serum TBC as previously described. 12,13,98,99 Additionally, photomicrograph section of hepatic tissues of fibrotic rats ( Figure 6) revealed and confirmed CCl 4 -induced necrosis and steatosis as previously described. 12,13,88,106 The localized distortions in hepatic architecture, persistence of hepatic steatosis and hydropic degenerations in fibrotic rats following treatment with raw and hydrothermal processed herbs were indications, which confirmed limited capacities of the herbs to ameliorate CCl 4 -induced morphological and functional impairments of hepatic tissues within the experimental period of 28 days.…”

Section: Discussionsupporting

confidence: 83%

“…•− and Cl 3 COO •− radicals generated from CCl 4 metabolism promoted membrane lipid peroxidation, in which the erythrocytes 99 and hepatorenal tissues were vulnerable 1,9,11-14 and consequently, prompted rapid haemolysis and hepatic necrosis with attendant hyperbilirubinemia in the experimental rats (Groups 3-12). The results of the present study ( Figure 2) indicated that fibrotic rats, regardless of the type of herbal treatment administered, presented evidence of hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 99%

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Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Ojiako¹,

Chikezie²,

Ukairo³

et al. 2017

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Background and Aim: Herbal remedies offer another strategy for alleviation of co-existing liver and kidney pathologic conditions. Objective: The present study ascertained the functional integrity of hepatic and renal tissues, concurrently with blood lipid patterns, of Wistar rats infused with CCl 4 and treated with raw and hydrothermal processed herbs, namely, Monodora myristica, Chromolaena odorata, Buccholzia coriacea and Sphenostylis stenocarpa. Materials and Methods: Measurement of phytochemical contents of the herbs was according to standard methods. The rats were randomly designated on the basis of diets and treatments received for 28 consecutive days. Fibrosis was induced in the Wistar rats by single dose intra-peritoneal injection of CCl 4 for 2 consecutive days. Liver and kidney function tests and serum lipid profile were measured using spectrophotometric methods. Renal and hepatic tissues were subjected to histopathological examinations. Results: The concentrations of alkaloids in the four herbal extracts were within the range of 4.83 ± 0.03 -31.33 ± 0.29 mg/100 g sample, whereas the concentrations of saponins varied within a relatively narrow range: 0.33 ± 0.09 -4.33 ± 0.02 mg/100 g dry sample; p > 0.05. The activity ratios of AST to ALT of the rat groups were generally less than 1.0 unit. Atherogenic indices of fibrotic rats were within the following ranges: TAG/HDL-C ratio (3.59 ± 0.03 -6.76 ± 0.06), TC/HDL-C ratio (3.72 ± 0.02 -6.94 ± 0.05) and LDL-C/HDL-C ratio (2.00 ± 0.01 -4.59 ± 0.02). Conclusion: Losses in phytochemical contents following hydrothermal processing of the herbs did not substantially affect their overall therapeutic scores against morphological and functional impairments of hepatic and renal tissues following CCl 4 intoxication of the rats.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Ojiako¹,

Chikezie²,

Ukairo³

et al. 2017

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“…LPO levels, detected by the TBARS technique, were higher in the TAA group and reduced in both MLT-treated groups, suggesting its protective effect. In amitriptyline-induced hepatotoxicity, in cirrhosis by carbon tetrachloride use and by bile duct ligation, MLT-treated animals also achieved significantly lower LPO [41,[44][45][46]. Similar results were obtained with quercetin and glutamine in the treatment of TAA-induced ALF [16,39].…”

Section: Lipoperoxidationmentioning

confidence: 76%

Action of Melatonin on Severe Acute Liver Failure in Rats

Salvi¹,

Schemitt²,

Colares³

et al. 2017

IOSRJPBS

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Abstract:Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24-and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.

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“…Several studies have shown that melatonin administration has protective effects against cholestatic liver damage through its antioxidant, anti-inflammatory, and proapoptotic proprieties (19,28,29,46). Recently, studies have demonstrated the antiproliferative effects of melatonin on cholangiocytes in animal models of extrahepatic cholestasis as well as cholangiocarcinoma (26,44,45).…”

mentioning

confidence: 99%

Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis

Han

Onori

Meng³

et al. 2014

American Journal of Physiology-Gastrointestinal and Liver Physi

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Biliary hyperplasia and liver fibrosis are common features in cholestatic liver disease. Melatonin is synthesized by the pineal gland as well as the liver. Melatonin inhibits biliary hyperplasia of bile duct-ligated (BDL) rats. Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase, AANAT) from the pineal gland increases after dark exposure, we hypothesized that biliary hyperplasia and liver fibrosis are diminished by continuous darkness via increased melatonin synthesis from the pineal gland. Normal or BDL rats (immediately after surgery) were housed with light-dark cycles or complete dark for 1 wk before evaluation of 1) the expression of AANAT in the pineal gland and melatonin levels in pineal gland tissue supernatants and serum; 2) biliary proliferation and intrahepatic bile duct mass, liver histology, and serum chemistry; 3) secretin-stimulated ductal secretion (functional index of biliary growth); 4) collagen deposition, liver fibrosis markers in liver sections, total liver, and cholangiocytes; and 5) expression of clock genes in cholangiocytes. In BDL rats exposed to dark there was 1) enhanced AANAT expression/melatonin secretion in pineal gland and melatonin serum levels; 2) improved liver morphology, serum chemistry and decreased biliary proliferation and secretin-stimulated choleresis; and 4) decreased fibrosis and expression of fibrosis markers in liver sections, total liver and cholangiocytes and reduced biliary expression of the clock genes PER1, BMAL1, CLOCK, and Cry1. Thus prolonged dark exposure may be a beneficial noninvasive therapeutic approach for the management of biliary disorders.

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Melatonin protects the liver and erythrocytes against oxidative stress in cirrhotic rats

Abstract: The data allow us to suggest that the observed oxidative stress is related to the damages caused by carbon tetrachloride and that the use of melatonin can minimize these damages.

Cited by 29 publications

References 43 publications

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

Action of Melatonin on Severe Acute Liver Failure in Rats

Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis

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