1997
DOI: 10.1016/s0306-4522(97)00262-5
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Melatonin protects against lipid peroxidation induced by δ-aminolevulinic acid in rat cerebellum, cortex and hippocampus

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Cited by 60 publications
(35 citation statements)
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“…Conversely, melatonin has been widely reported as a potent antioxidant (Marshall et al, 1996;Reiter et al, 1997;) that protects against LPO (Carneiro and Reiter, 1998) and increases both activity and expression of antioxidant enzymes (Rodriguez et al, 2004). Therefore, the age-related decrease in melatonin levels may contribute to aging process.…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, melatonin has been widely reported as a potent antioxidant (Marshall et al, 1996;Reiter et al, 1997;) that protects against LPO (Carneiro and Reiter, 1998) and increases both activity and expression of antioxidant enzymes (Rodriguez et al, 2004). Therefore, the age-related decrease in melatonin levels may contribute to aging process.…”
Section: Discussionmentioning
confidence: 99%
“…In our experimental model, melatonin, 6-hydroxymelatonin or N-acetylserotonin was intraperitoneally administered to the rats at a dose of 10 mg/kg body weight 30 min before the ANIT injection and 6, 12, and 18 h after ANIT The number of polymorphonuclear neutrophils and apoptotic cells were assayed in control rats (C), rats injected with melatonin (MEL), 6-hydroxymelatonin injection. This experimental injection schedule for melatonin and related indoles has been used in other experimental models and been found effective in reducing oxidative damage [Sewerynek et al, 1995;Carneiro and Reiter, 1998]. Melatonin, and to a lesser degree 6-hydroxymelatonin, as able to protect against ANIT-induced liver injury with cholestasis as demonstrated by the serum values of both SGPT and SGOT activities and total bilirubin concentration.…”
Section: Discussionmentioning
confidence: 99%
“…Groups I (control) and V (ANIT) received the dose intraperitoneally and at the same time the same volume of ethanol/saline solution. This scheme of indole administration has been previously used and found effective in reducing oxidative damage [Sewerynek et al, 1995;Carneiro and Reiter, 1998]. Beginning at the time of ANIT administration and continuing to the end of the study all animals had free access to food and water.…”
Section: Methodsmentioning
confidence: 99%
“…HIV-1 protease-induced apoptotic cell death was prevented by kynostatin (KNI-272, a selective protease inhibitor) I17] and endogenous antioxidants such as 1713-estradiol [11,42], melatonin [5], and S-nitrosoglutathione [29]. After replicating these findings in vivo, centrally active protease inhibitors and antioxidants can be developed and used for retarding protease-induced progressive cerebral atrophy and associated neuropsychiatric syndrome and dementia complex.…”
Section: Introductionmentioning
confidence: 99%