Melatonin prevents radiation‐induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis

Köse, Oğuz; Arabacı, Taner; Kızıldağ, Alper; Erdemci, Burak; EMİNOĞLU, Didem ÖZKAL; Gedikli, Semin; Özkanlar, Seçkin; Zihni, Meltem; Albayrak, Mevlüt; Kara, Adem; Kermen, Eda

doi:10.1111/jre.12409

Cited by 32 publications

(26 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Melatonin use has been observed to significantly reduce regional alveolar bone resorption in rats. However, the data do not distinguish whether melatonin improved the effects of radiotherapy or of periodontitis alone ( 39 ).…”

Section: Review Of Literaturementioning

confidence: 99%

Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians

Irie¹,

Mendes²,

Borges³

et al. 2018

Med Oral

View full text Add to dashboard Cite

BackgroundTo review and discuss important topics regarding periodontal treatment pre- and post-radiotherapy for head and neck cancer in human patients; to discuss the references for adequate techniques, the appropriate moment for tooth extractions and periodontal management; and to discuss the prevention of osteoradionecrosis.Material and MethodsThirty-nine studies including original studies, randomized clinical trials (RCTs) and reviews were searched in online databases MEDLINE (PubMed) and the Cochrane library. No year of publication restriction was applied.ResultsLanguage was restricted to English, and the following Medical Subject Heading terms were used: radiotherapy, radiation therapy and periodontal treatment. Studies regarding periodontal treatment and tooth extraction that involved clinical management of irradiated patients were selected.ConclusionsThe treatment of periodontal diseases before radiotherapy is mainly required to avoid future dental extraction and to reduce the development of osteoradionecrosis. Periodontal treatment in irradiated patients mostly includes scaling and root planing, extraction of condemned teeth and topical and systemic antimicrobial therapy. Tooth removal should be planned at least 14 days before the first day of radiation treatment. Particular care and mouthwashes should be taken during and after radiation.Clinical SignificanceThe management of irradiated patients represents a challenge for health professionals, including dentists. It is important to establish recommendations for clinicians concerning dental and periodontal management in irradiated patients before, during and after treatment. Key words:Head and neck cancer, radiotherapy, periodontal treatment, periodontitis.

show abstract

Section: Review Of Literaturementioning

confidence: 99%

Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians

Irie¹,

Mendes²,

Borges³

et al. 2018

Med Oral

View full text Add to dashboard Cite

show abstract

“…The most promising candidate drug at least according to animal experiments is melatonin. This amphiphile molecule has an optimal distribution in the tissues and can, thus, reach the periodontal tissues even after systemic administration (Köse et al, 2017 ). Of special clinical relevance is the induction of periodontitis in diabetic rats since periodontitis is a common complication of diabetes in humans.…”

Section: Animal Experimentsmentioning

confidence: 99%

Oxidative Stress and Antioxidants in the Diagnosis and Therapy of Periodontitis

2017

View full text Add to dashboard Cite

Oxidative stress has been implicated in the pathogenesis of numerous diseases. However, large interventional studies with antioxidants failed to show benefits in the prevention or treatment of cardiovascular diseases, cancer, or diabetes mellitus. Numerous clinical studies have confirmed the association of oxidative stress markers and periodontitis. Technical and biological variability is high for most of the analyzed markers and none of them seems to be optimal for routine clinical use. In a research setting, analysis of a palette of oxidative stress markers is needed to cover lipid peroxidation, protein oxidation, and the antioxidant status. The source of reactive oxygen species and their role in the pathogenesis of periodontitis remains unclear. Interventional experiments indicate that oxidative stress might be more than just a simple consequence of the inflammation. Small studies have confirmed that some antioxidants could have therapeutic value at least as an addition to the standard non-surgical treatment of periodontitis. A clear evidence for the efficiency of antioxidant treatment in large patient cohorts is lacking. Potentially, because lowering of oxidative stress markers might be a secondary effect of anti-inflammatory or antibacterial agents. As the field of research of oxidative stress in periodontitis gains attraction and the number of relevant published papers is increasing a systematic overview of the conducted observational and interventional studies is needed. This review summarizes the currently available literature linking oxidative stress and periodontitis and points toward the potential of adjuvant antioxidant treatment, especially in cases where standard treatment fails to improve the periodontal status.

show abstract

“…The second main objective of the present study was to investigate the possible effects of melatonin treatment on periodontitis-related changes in left ventricular tissue. Histological and radiological evidence showing a significant decrease of alveolar bone loss by melatonin administration may be related to the strong antioxidant, 8,17 anti-inflammatory, [15][16][17] and antiresorptive 8,14,16,17 effects reported by experimental and clinical studies.…”

Section: Discussionmentioning

confidence: 87%

“…Simko et al 10 showed that melatonin administration significantly treated hypertension and increased oxidative stress in left ventricle and aorta, left ventricular hypertrophy, and fibrosis caused by continuous exposure to light. Moreover many human [13][14][15] and animal 8,12,16,17 studies demonstrated that systemic 8,13,16 or local 14,15 melatonin administration significantly limits periodontal tissue destruction via antioxidant, anti-inflammatory, and immunomodulatory effects.…”

Section: Introductionmentioning

confidence: 99%

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

Köse

Bayrakdar

Akyıldız

et al. 2020

Journal of Periodontology

View full text Add to dashboard Cite

Background: The aim of this experimental rat study was to investigate the potential inflammatory effects of periodontitis on cardiac left ventricular tissue and the therapeutic activity of melatonin on these effects. Methods: Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-melatonin (Ep-Mel). Experimental periodontitis was induced by placing and maintaining 3.0 silk ligatures at a peri marginal position on the left and right mandibular first molars for 5 weeks. Afterward, following the removal of ligatures, melatonin (10 mg/body weight) to Ep-Mel group, and vehicle (saline) to Ep and control groups were administered intraperitoneally for 14 days. On the first day of the eighth week, mandibular and cardiac left ventricular tissue samples were obtained following the euthanasia of the rats in all groups. Alveolar bone loss measurements were made on histological and microcomputed tomographic slices. Cardiac tissue levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), matrix metalloproteinase-9 (MMP-9), and cardiac Troponin-T (cTnT) were evaluated by appropriate biochemical methods. Results: Measurements made on the histological and microcomputed tomographic slices showed that melatonin significantly limits the ligature-induced periodontal tissue destruction (P <0.01). In addition, melatonin was detected to cause a significant decrease of MDA, MMP-9, and cTnT levels which were found to be significantly higher on rats with Ep (P <0.05) while having no significant effect on antioxidant levels (GSH, SOD, and CAT) (P >0.05). Conclusion: Melatonin might be regarded as an important supportive therapeutic agent to reduce the early degenerative changes and possible hypertrophic remodeling at cardiac left ventricular tissues provoked by periodontitis-related bacteria and/or periodontal inflammation.

show abstract

Melatonin prevents radiation‐induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis

Cited by 32 publications

References 53 publications

Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians

Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians

Oxidative Stress and Antioxidants in the Diagnosis and Therapy of Periodontitis

Melatonin ameliorates periodontitis‐related inflammatory stress at cardiac left ventricular tissues in rats

Contact Info

Product

Resources

About