volume 9, issue 6, P1552-1564 2017
DOI: 10.18632/aging.101252
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Tao Wang, Ying-Ying Gao, Li Chen, Zheng-Wen Nie, Wei Cheng, Xiaoyan Liu, Heide Schatten, Xia Zhang, Yi-Liang Miao

Abstract: Oxidative stress is known as a major contributing factor involved in oocyte aging, which negatively affects oocyte quality and development after fertilization. Melatonin is an effective free radical scavenger and its metabolites AFMK and AMK are powerful detoxifiers that eliminate free radicals. In this study, we used porcine oocytes to test the hypothesis that melatonin could scavenge free radicals produced during oocyte aging, thereby maintaining oocyte quality. We compared reactive oxygen species levels, ap…

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