Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma

Gubin, Denis; Нероев, В. В.; Малишевская, Т. Н.; Cornélissen, Germaine; Astakhov, Sergei Y; Коломейчук, С. Н.; Yuzhakova, Natalya; Kabitskaya, Yana; Weinert, Dietmar

doi:10.1111/jpi.12730

Cited by 39 publications

(28 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Through this mechanism, Martínez-Águila et al [ 227 , 228 ] demonstrated that the topical instillation of melatonin and its analogs 5-methoxycarbonylamino N-acetyl tryptamine (5-MCA-NAT) and agomelatine reduced the intraocular pressure in rabbits and mice. In normotensive subjects, two clinical studies found that the short- and mid-term oral administration of nutritional supplements based on melatonin reduced by 1 mmHg the intraocular pressure [ 229 , 230 ], which are values not considered clinically relevant.…”

Section: Treatmentmentioning

confidence: 99%

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

et al. 2021

View full text Add to dashboard Cite

Most irreversible blindness observed with glaucoma and retina-related ocular diseases, including age-related macular degeneration and diabetic retinopathy, have their origin in the posterior segment of the eye, making their physiopathology both complex and interconnected. In addition to the age factor, these diseases share the same mechanism disorder based essentially on oxidative stress. In this context, the imbalance between the production of reactive oxygen species (ROS) mainly by mitochondria and their elimination by protective mechanisms leads to chronic inflammation. Oxidative stress and inflammation share a close pathophysiological process, appearing simultaneously and suggesting a relationship between both mechanisms. The biochemical end point of these two biological alarming systems is the release of different biomarkers that can be used in the diagnosis. Furthermore, oxidative stress, initiating in the vulnerable tissue of the posterior segment, is closely related to mitochondrial dysfunction, apoptosis, autophagy dysfunction, and inflammation, which are involved in each disease progression. In this review, we have analyzed (1) the oxidative stress and inflammatory processes in the back of the eye, (2) the importance of biomarkers, detected in systemic or ocular fluids, for the diagnosis of eye diseases based on recent studies, and (3) the treatment of posterior ocular diseases, based on long-term clinical studies.

show abstract

Section: Treatmentmentioning

confidence: 99%

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The precise etiological mechanisms underlying OSA-mediated glaucoma remain unclear, but there are several possible explanations. One theory suggests “mechanical” damage due to nocturnal increased IOP from supine sleep posture, altered sleep hormone balance (a nocturnal serum melatonin peak, which is associated with lowered IOP during sleep, was absent in OSA patients), obesity with excessive intraorbital adipose tissue or increased episcleral venous pressure, and autonomic dysfunction [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Another theory explores ischemia or abnormal perfusion as the cause of optic disc vulnerability leading to the observed normal IOP value [ 38 ].…”

Section: Osa-associated Complications In Optic Nervementioning

confidence: 99%

Ocular Complications of Obstructive Sleep Apnea

Liu

Chiu

Wang

et al. 2021

JCM

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA), the most common form of sleep-disordered breathing, is characterized by repetitive episodes of paused breathing during sleep, which in turn induces transient nocturnal hypoxia and hypercapnia. The high prevalence of OSA and its associated health consequences place a heavy burden on the healthcare system. In particular, the consequent episodic oxygenic desaturation/reoxygenation series and arousals from sleep in patients with OSA have the potential to trigger oxidative stress, elevated systemic inflammatory responses, and autonomic dysfunction with sympathetic activation. Given these adverse side-effects, OSA is highly correlated to many eye diseases that are common in everyday ophthalmic practices. Some of these ocular consequences are reversible, but they may permanently threaten a patient’s vision if not treated appropriately. Here, this article seeks to review the ocular consequences and potential pathophysiologic associations in patients with OSA. Understanding these OSA-related eye diseases may help clinicians provide comprehensive care to their patients.

show abstract

“…Измерения подмышечной температуры тела (ТТ) проводили 7 раз в сутки (в 8:00, 11:00, 14:00, 17:00, 19:00, 23:00 и 3:00 ч) в течение 3 последовательных дней (72 ч) по Тюменскому протоколу [34,35] ртутным термометром (Amrus AMTD, Amrus Enterprises Ltd., США).…”

Section: материал и методыunclassified

The connection of polymorphism and diurnal changes of the biological clock gene expression with the risk of progression of primary open-angle glaucoma

Власова

Petrov

Малишевская

et al. 2021

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

The purpose of this work is to study the connection betweengenetic factors (polymorphism and expression of key genes of the biological clock (KGBC), key genes controlled by KGBC, melatonin receptors) and the diurnal oscillation of melatonin in patients with stable and progressing primary open-angle glaucoma. Materials and methods. The study involved 115 patients aged 53–86 (averagely, 68.8 ± 7.9 years) with stable and progressive glaucoma. All patients underwent primary ophthalmological examination, tested for diurnal body temperature profile, intraocular pressure (IOP), melatonin (by the DLMO protocol) and were typed for key genes of the biological clock using the real-time polymerase chain reaction. We studied the sleep phase shift to later hours in carriers of the G-allele of the melatonin receptor gene during the progression of glaucoma. Results. The study of the clinical and genotypic features of the POAG course revealed phasal shifts of the circadian rhythms of body temperature, IOP, salivary melatonin levels and sleep phases which contributed to the progression of glaucomatous optic neuropathy. Certain polymorphic variants of genes contribute to individual frequent manifestations of desynchronosis. The clock rs1801260 and MTNR1B rs10830963 gene polymorphism was found to be related to disturbances in melatonin production and sleep phase. Conclusion. Complex manifestations of circadian desynchronization accompanying the progressive course of glaucoma are the late phase of rhythms and a decrease in sleep duration, body temperature, salivary melatonin and IOP, internal desynchronization between IOP and body temperature, IOP and sleep, evening dyslipidemia. The revealed patterns open up prospects for future studies of the relationship between polymorphism and daily changes of the expression of key genes in the biological clock with the risk of progression of primary open angle glaucoma.

show abstract

Melatonin mitigates disrupted circadian rhythms, lowers intraocular pressure, and improves retinal ganglion cells function in glaucoma

Cited by 39 publications

References 87 publications

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

From Oxidative Stress to Inflammation in the Posterior Ocular Diseases: Diagnosis and Treatment

Ocular Complications of Obstructive Sleep Apnea

The connection of polymorphism and diurnal changes of the biological clock gene expression with the risk of progression of primary open-angle glaucoma

Contact Info

Product

Resources

About