Melatonin influence in ovary transplantation: systematic review

Shiroma, Marcos Eiji; Botelho, Nara Macedo; Damous, Luciana Lamarão; Baracat, Edmund Chada; Soares-Jr, José Maria

doi:10.1186/s13048-016-0245-8

Cited by 22 publications

(19 citation statements)

References 21 publications

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“…By all indices, the benefits of melatonin exceed those of AA and suggest tests of this important molecule in additional transplantation studies, including in clinical trials. The findings related to the likely utility of melatonin in organ transplantation have recently been reviewed, and, in a separate report, melatonin was also suggested for use in ovary transplantation …”

Section: Melatonin As An Antioxidant: Waging War On Free Radicalsmentioning

confidence: 99%

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Melatonin as an antioxidant: under promises but over delivers

Reíter

Mayo

Tan

et al. 2016

Journal of Pineal Research

1,279

1,040

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Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and reactive nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing the activity of pro-oxidant enzymes. In addition to these well-described actions, melatonin also reportedly chelates transition metals, which are involved in the Fenton/Haber-Weiss reactions; in doing so, melatonin reduces the formation of the devastatingly toxic hydroxyl radical resulting in the reduction of oxidative stress. Melatonin's ubiquitous but unequal intracellular distribution, including its high concentrations in mitochondria, likely aid in its capacity to resist oxidative stress and cellular apoptosis. There is credible evidence to suggest that melatonin should be classified as a mitochondria-targeted antioxidant. Melatonin's capacity to prevent oxidative damage and the associated physiological debilitation is well documented in numerous experimental ischemia/ reperfusion (hypoxia/reoxygenation) studies especially in the brain (stroke) and in the heart (heart attack). Melatonin, via its antiradical mechanisms, also reduces the toxicity of noxious prescription drugs and of methamphetamine, a drug of abuse.Experimental findings also indicate that melatonin renders treatment-resistant cancers sensitive to various therapeutic agents and may be useful, due to its multiple antioxidant actions, in especially delaying and perhaps treating a variety of agerelated diseases and dehumanizing conditions. Melatonin has been effectively used to combat oxidative stress, inflammation and cellular apoptosis and to restore tissue function in a number of human trials; its efficacy supports its more extensive use in a wider variety of human studies. The uncommonly high-safety profile of melatonin also bolsters this conclusion. It is the current feeling of the authors that, in view of the widely diverse beneficial functions that have been reported for melatonin, these may be merely epiphenomena of the more fundamental, yet-to-be identified basic action(s) of this ancient molecule. K E Y W O R D Sdiseases of aging, drug toxicity, free radicals, ischemia/reperfusion, mitochondria-targeted antioxidant, organ transplantation, statins

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Section: Melatonin As An Antioxidant: Waging War On Free Radicalsmentioning

confidence: 99%

“…The findings related to the likely utility of melatonin in organ transplantation have recently been reviewed, 251,252 and, in a separate report, melatonin was also suggested for use in ovary transplantation. 253…”

Section: Melatonin As An Antioxidant: Evidence From Organ Transplanmentioning

confidence: 99%

Melatonin as an antioxidant: under promises but over delivers

Reíter

Mayo

Tan

et al. 2016

Journal of Pineal Research

1,279

1,040

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“…The severities of the immune disorders are proportional to the extent of the surgical trauma [1][2][3] . In addition to the cytokines' actions on wound healing, the mobilization of macrophages is responsible for the production of growth factors, such as vascular endothelial growth factor (VEGF), which are essential for the development of surgical scars and granulation tissue 4,5 .…”

Section: ■ Introductionmentioning

confidence: 99%

A prospective randomized study of the inflammatory responses to multiport and singleport laparoscopic hysterectomies

Tormena

Ribeiro²,

Soares³

et al. 2017

Acta Cir. Bras.

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A prospective randomized study of the inflammatory responses to multiport and singleport laparoscopic hysterectomies 1 AbstractPurpose: To evaluate the inflammatory responses induced by laparoscopic hysterectomies with multiport and singleport approaches.Methods: This was a pilot prospective randomized study that included 42 women candidates for hysterectomy at School of Medicine, Hospital das Clínicas, USP. The patients were randomized to two groups: MP-TLH (total laparoscopic hysterectomy with 3 abdominal incisions), and SP-TLH (total laparoscopic hysterectomy with a single umbilical incision). We evaluated the inflammatory response (via CRP, IL-6, IL-10, TNFα, VEGF and leukogram assessments), surgical time, postoperative pain, blood loss and surgical complications in both groups. Results: Both techniques were similar regarding C-reactive protein (p=.666), IL-6 (p=.833), IL-10 (p=.420), TNF-α(p=.098), VEGF (p=.092) and the leukogram (p=.712) measures. The operative time was significantly longer in the SP-TLH group than in the MP-TLH group (p=.001). The pain evaluation was similar in both groups (p=.170). Hemoglobin variation and the aspirated blood volume were similar in both groups (p=.493 and p=.347). There were no major complications. Conclusions: Multiport and singleport laparoscopic approaches are both safe methods for hysterectomy. Although SP-TLH resulted in a significantly longer operative time than MP-TLH, no differences were observed between the groups in inflammatory responses, blood loss and postoperative pain.

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“…In addition to the use of angiogenic biomaterial or cotransplantation of endothelial cells, graft treatment with VEGFs and Vitamin E and host treatment with Vitamin E and gonadotropins resulted in a better transplantation outcomes (Abir et al, ). Melatonin was used in animal ovary transplantation studies to enhance graft outcomes (Friedman et al, ) (Shiroma, Botelho, Damous, Baracat, & Soares‐Jr, ). These trials currently remain at the animal experiment stage but can be extended to human studies in the future.…”

Section: Transplantation Sites and Surgical Considerationsmentioning

confidence: 99%

“…Melatonin was used in animal ovary transplantation studies to enhance graft outcomes (Friedman et al, 2012) (Shiroma, Botelho, Damous, Baracat, & Soares-Jr, 2016). These trials currently remain at the animal experiment stage but can be extended to human studies in the future.…”

Section: When Heterotopic Transplantation Is Conducted Several Factorsmentioning

confidence: 99%

A new possibility in fertility preservation: The artificial ovary

Cho

Kim

Noh

et al. 2019

J Tissue Eng Regen Med

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Conventional fertility preservation methods such as oocyte or embryo cryopreservation are currently insufficient to treat including those patients with prepubertal cancer and premature ovarian failure. Ovarian tissue cryopreservation presents as an alternative but has limitations with a potential risk of reintroducing malignant cells in patients who recover from cancer, those of chemotherapy prior to tissue cryopreservation. The so called “artificial ovary” aims to resolve this issue by transplanting isolated follicles with or without a biological scaffold. The artificial ovary may also offer an effective alternative option for those who cannot benefit from traditional assisted reproductive techniques such as in vitro fertilisation. To date, in animal studies and human trial, the artificial ovary restored endocrine function, achieved in vivo follicular development, and resulted in successful pregnancies. However, development of a technique for higher follicular recovery rate and a more optimised design of delivery scaffold, better transplantation techniques to prevent postsurgical ischemia, and consideration for genetic safety are required for safer and consistent human clinical applications. Ideas from different transplantation surgeries (e.g., entire ovary, ovarian cortex, and transplantation with tissue‐engineered products) can be applied to enhance the efficacy of artificial ovarian transplantation. For the better application of artificial ovary, a deeper understanding of mechanical and biochemical properties of the ovary and folliculogenesis after cryopreservation, transplantation with or without scaffold, and development of sophisticated in vivo imaging techniques of transplanted artificial ovary need to precede its efficient clinical application.

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Melatonin influence in ovary transplantation: systematic review

Cited by 22 publications

References 21 publications

Melatonin as an antioxidant: under promises but over delivers

Melatonin as an antioxidant: under promises but over delivers

A prospective randomized study of the inflammatory responses to multiport and singleport laparoscopic hysterectomies

A new possibility in fertility preservation: The artificial ovary

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