Melatonin in Schizophrenic Outpatients With Insomnia

Kumar, Prawin; Andrade, Chittaranjan; Bhakta, Savita; Singh, Namrata

doi:10.4088/jcp.v68n0208

Cited by 90 publications

(33 citation statements)

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“…It remains unclear whether these results could be also related, at least partially, to the influence of antipsychotic medications and light exposure. The efficacy of exogenous melatonin in treating insomnia associated with schizophrenia was reported by Suresh Kumar et al [30]. In the double-blind, placebo-controlled study, relative to placebo, melatonin significantly improved the quality and depth of nighttime sleep, reduced the number of nighttime awakenings, and increased the duration of sleep without yielding a morning hangover.…”

Section: Circadian Disturbances and Psychosismentioning

confidence: 90%

Jet Lag and Psychotic Disorders

Katz

2011

Curr Psychiatry Rep

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Jet lag syndrome appears after multiple time zone transitions as bodily rhythms shift out of phase with the local environment. The possible psychiatric complications of jet lag have been underinvestigated. In the present review, the symptoms of jet lag in the general population, the chronobiological aspects of psychosis, as well as a possible correlation between jet lag and psychosis are discussed. The conclusions are that jet lag, through disruption of biological rhythm and probably sleep deprivation, may yield an exacerbation of existing psychotic conditions. The evidence concerning the appearance of de novo psychosis triggered by jet lag is inconsistent and far from convincing.

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Section: Circadian Disturbances and Psychosismentioning

confidence: 90%

Jet Lag and Psychotic Disorders

Katz

2011

Curr Psychiatry Rep

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“…Data are also accruing that the therapeutic effects of melatonin are in part due to their anti-inflammatory effects. While further research is required to determine the optimal recommended doses (3-12 mg of melatonin is currently commonly used to promote sleep), psychiatrists can recommend doses of melatonin based on previous and current efficacious studies and then adjust the doses based on the results obtained (Cheung et al, 2006;Pignone et al, 2006;Suresh et al, 2007). Also, the use of melatonin in combination with currently used pharmaceuticals requires additional investigation.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin is an agent with the capacity of entraining of circadian rhythms (chronobiotic effect) as well as having sleep promoting effects and neuroprotective actions (Reiter and Benitez-King, 2009;Reiter et al, 2005a,b;Srinivasan et al, 2006). These properties have been documented in clinical trials with humans as well as in experimental animals (Paredes et al, 2007;Suresh et al, 2007;Wyatt et al, 2006). Considering these effects, melatonin could be a viable strategy to reduce circadian disruption and improve the sleep of patients with schizophrenia.…”

Section: Reasons To Use Melatonin In Schizophreniamentioning

confidence: 99%

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Melatonin as a potential therapeutic agent in psychiatric illness

Maldonado

Reíter

Pérez-San-Gregorio

2009

Human Psychopharmacology

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The aim of this review was to summarize the potential use of melatonin in the treatment of mental disorders, specifically bipolar disorders, depression, and schizophrenia. To date, melatonin has been most commonly used in psychiatry because of its hypnotic, rhythm resynchronizing, and antioxidant actions. Here, we examine other properties of the melatonin including its anti-inflammatory, antinociceptive, anxiolytic, and drug detoxification actions as well as its protective effects against neural loss. The brain is an intricate sensory and motor organ which receives information from both the external and internal environments. It transduces information into complex chemical and electrical signals which are transmitted throughout the central nervous system (CNS) and the organism. The pathogenesis of mental disorders remains ambiguous and neuroinflammation has been proposed as a causative agent. We consider the potential contributions of melatonin as therapeutic agent in CNS and during neuroinflammation in mental disorders.

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“…Ancak şizofreni hastalarında yapılan çalışmalarda sirkadiyen ritim bozukluğuna ve düşük serum melatonin düzeylerine rastlanmıştır. [117] Özellikle şizofreni hastalarında psikotik atak döneminde ve yoğun antipsikotik kullanılan dönemde uyku sorunları yoğun bir şekilde yaşanmak-tadır. Bu nedenle melatonin kullanımının sirkadiyen ritmi bozmadan ve yan etki oluşturmadan şizofreni hastalarının uyku sorunlarını çözebileceği düşü-nülmektedir.…”

Section: Melatonin Ve Psikiyatrik Hastalıklarunclassified

An Overview On Melatonin Hormone

Özçeli̇k¹,

Erdem²,

Bolu³

et al. 2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZETMelatonin hormonu, son yıllarda tüm dünyada gittikçe artan bir ilgiyle araştı-rılmaktadır. Ana görevi vücudun biyolojik saatini koruyup ritmini ayarlamak olan melatonin, vücudun birçok biyolojik ve fizyolojik süreçlerinde yer alır. Hücrelerin yenilenmesi, bağışıklık siteminin güçlenmesi, uyku ritminin ve vücut ısısının düzenlenmesi diğer önemli görevleri arasındadır. Lipofilik özel-liği nedeniyle bilinen en güçlü antioksidandır. Bu özelliği sayesinde tüm vücut alanlarına ulaşabilmekte ve kan-beyin bariyerini geçebilmektedir. Uyku problemi olan kişilerde melatoninin düşük düzeyde bulunması, ilaç olarak kullanımını akla getirmektedir. Yapılan uygulamaların ardından melatoninin uyku total süresini değiştirmeden uyku kalitesini artırdığı belirlenmiştir. Ancak yaygın araştırılmasına rağmen melatoninin işlevleri halen tamamıyla bilinmemektedir. Bu nedenle melatonin ile ilgili mevcut bilgilerin gözden geçirilmesi, bu alanda araştırma yapanlara rehberlik edecektir. Anahtar Sözcükler: Melatonin, uyku, biyolojik saat, antioksidan. ABSTRACTIn recent years, there is a growing interest in melatonin all over the world. The main task of protecting the body's biological clock, which set the rhythm of melatonin, involves many biological and physiological processes of the body. Cell renewal, strengthening of the immune system and body temperature regulation are other tasks of melatonin. Melatonin, with its lipophilic property, is the most powerful antioxidant as it can reach all body areas and can easily pass the blood-brain barrier. The fact that individuals with low levels of melatonin have sleep problems lead to the consideration of melatonin as a therapeutic medicine in this field. The detailed researches have shown that melatonin can improve sleep quality without changing the total duration of sleep. Nevertheless, despite high number of researches done, the functions ©2013, Psikiyatride Güncel Yaklaşımlar eISSN:1309-0674 pISSN:1309-0658

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Melatonin in Schizophrenic Outpatients With Insomnia

Cited by 90 publications

References 0 publications

Jet Lag and Psychotic Disorders

Jet Lag and Psychotic Disorders

Melatonin as a potential therapeutic agent in psychiatric illness

An Overview On Melatonin Hormone

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