Melatonin decreases apoptosis and expression of apoptosis-associated proteins in acute puromycin aminonucleoside nephrosis

Pedreáñez, Adriana; Rincón, Jaimar; Romero, Maritza J.; Viera, Ninoska; Mosquera, Jesús

doi:10.1093/ndt/gfh068

Cited by 19 publications

(18 citation statements)

References 15 publications

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“…As previously mentioned, the anti-apoptotic action of melatonin has also been reported in nervous and renal tissues 7 ; in this case, treatment with the hormone causes a decrease in the expression levels of proteins Fas, Fas-L and p-53, along with an increase in the expression of Bcl-2 11 . However, the mechanisms involved in the control of these genes' expression, as well as the end of the apoptosis cascade (caspase-3-cleaved) require further investigation.…”

Section: Melatonin Action In Apoptosismentioning

confidence: 61%

“…The Bcl-2 protein, for example, inhibits the release of cytochrome C by the mitochondrias, thus preventing cell death 11,12,25 . However, although the antiapoptotic role of these proteins has been thoroughly documented, little is known about the precise mechanism through which Bcl-2 and the other members of this family can act in this process 4 .…”

Section: Inhibitors Of Caspase Activation In Apoptosismentioning

confidence: 99%

“…In addition to being used to increase sleep efficiency 28 , treat jet lag, improve the cardiovascular system 29 , as an antiaging drug 28 , diet supplement, or as protection against the appearance of tumors 30 , there is evidence that it could play a part in controlling the cell death process, acting in apoptosis 11,12,31,32 .…”

Section: Melatoninmentioning

confidence: 99%

“…Some authors show an anti-apoptotic action of melatonin in different organs, such as thymus, kidney, brain and liver, attributing this mainly to its antioxidating properties [7][8][9][10][11][12]33,34 when eliminating radicals hydroxyl (OH -), peroxyl (ROO -) 26, superoxides 4 and cardiolipin oxidation from mitochondrias 35 . In the lacrimal glands of hamsters, this hormone prevents cell damage caused by the buildup of porphyrins, due to its capacity of decreasing the RNAm synthesis of aminolevulinate synthetase, enzyme involved in the production of porphyrins, and also due to increasing the levels of RNAm of antioxidating enzymes such as manganese superoxide dismutase (Mn-SOD) and copper-zinc superoxide dismutase (Cu-Zn-SOD) 36 .…”

Section: Melatonin Action In Apoptosismentioning

confidence: 99%

“…It influences the regulation of the neuroendocrine Review Article system, the control of circadian rhythms for various physiological processes, and the anti-apoptotic system in various cell deathinduced vertebrate tissues [9][10][11][12] . However, the mechanism through which melatonin exerts its inhibitory effect on cell death remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Melatonina: modulador de morte celular

Ferreira

Maganhin

Simões

et al. 2010

Rev. Assoc. Med. Bras.

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Apoptosis or planned cell death is a biological phenomenon that is essential for the development and maintenance of a cell population. In this process, senescent or damaged cells are eliminated after activation of a cell death program involving participation of pro-apoptotic molecules (Fas, Bax, caspases 2,3,6,7, 8 and 9). Molecule activation causes typical morphological changes, such as cell shrinkage, loss of adhesion to the extracellular matrix and neighboring cells, chromatin condensation, DNA fragmentation and formation of apoptotic bodies. Anti-apoptotic molecules (Bcl-2, FLIP) block the emergence and evolution of these cell changes and prevent cell death. The balance between pro-and anti-apoptotic molecules ensures tissue homeostasis. When apoptosis is out of control, it contributes to the emergence of several neoplastic, autoimmune and neurodegenerative diseases. Several inducing and inhibiting agents of apoptosis are recognized as potential weapons in the fight against disorders related to cell proliferation and death among, among which stand hormones out. Melatonin has been reported as an important anti-apoptotic agent in various tissues by reducing cell calcium uptake, mitigating the production of oxygen reactive species and decreasing pro-apoptotic proteins, such as Bax. The knowledge of new agents capable of acting on the course of apoptosis is important and valuable for developing further therapies against various diseases. Thus, the objective of this review was to clarify the main aspects of cell death by apoptosis and the role of melatonin in this process

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Section: Melatonin Action In Apoptosismentioning

confidence: 61%