Melatonin: An option for managing sleep disorders in children with autism spectrum disorder

Damiani, Justina M.; Sweet, Burgunda V.; Sohoni, Pamela

doi:10.2146/ajhp130215

Cited by 31 publications

(25 citation statements)

References 28 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rossignol and Frye found that hormone use did not lead to adverse events in 7 of 12 studies in which children with ASD were treated with melatonin [24] . Since melatonin is metabolized by CYP1A2 and CYP2C19, the use of drugs that inhibit CYP1A2 can raise the plasma levels of melatonin [25] . Since melatonin can lead to temporary pressure fluctuations or a decrease in blood sugar level ranges, attention should be given to the simultaneous use with drugs that regulate blood pressure and glucose metabolism [26] .…”

Section: Scheme Of the Biosynthesis Of Melatonin In Vivomentioning

confidence: 99%

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Volpe¹,

Lucia²,

Pirozzi³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

MATERIALS and METHODS:In total, 748 children aged between 12 and 48 months were included in the study and divided into three groups: A: placebo (n=235), B: melatonin (n=246), and C: melatonin, tryptophan, and vitamin B6 (n=267). RESULTS:In groups B and C, in addition to physiological awakening, we observed a significant reduction in the number of repeated analyses as well as drug regimen usage. CONCLUSION:This study confirms the strategic role of melatonin as an inducer of spontaneous sleep. However, above all, it suggests that the administration of a solution containing melatonin, tryptophan, and vitamin B6 significantly reduces the number of repeated ABR examinations as well as the percentage of repeated analysis performed using sedative drugs compared to both the control group and the melatonin-only group.

show abstract

Section: Scheme Of the Biosynthesis Of Melatonin In Vivomentioning

confidence: 99%

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Volpe¹,

Lucia²,

Pirozzi³

et al. 2017

Int Adv Otol

View full text Add to dashboard Cite

show abstract

“…Acetylserotonin methyltransferase is an enzyme needed in this biosynthesis. Children with ASD and ADHD have been suggested to have lower levels of this enzyme [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Large studies with many children are, however, lacking as are clear recommendations over dosing and appropriate treatment duration. There is also a lack of long-term studies that limits the knowledge of relapse risk and long-term safety and efficacy [9,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

The use of melatonin in Swedish children and adolescents—a register-based study according to age, gender, and medication of ADHD

Furster

Hallerbäck

2015

Eur J Clin Pharmacol

View full text Add to dashboard Cite

More Swedish boys than girls used melatonin regularly. The boys started treatment earlier and more often combined regular use of melatonin with regular use of medication for ADHD. This indicates that girls and boys partly are prescribed melatonin for different reasons. About half of the younger children stayed on melatonin treatment for several years, while 90% of adolescents (15-19 years) concluded their treatment.

show abstract

“…There is very little endogenous melatonin in infants under 3 months old; circadian secretion develops in older children, with peak nocturnal levels highest in the first 1–3 years of life, then there is a gradual decline in production, reaching a low level in old age 17,18…”

Section: About Melatoninmentioning

confidence: 99%

“…Another systematic review17 identified a further study28 that included 146 children aged 3–16 years with neurodevelopmental disorders, of whom some had autism spectrum disorder. They received placebo or melatonin (0.5–12mg), 45 minutes before bedtime for 12 weeks.…”

Section: About Melatoninmentioning

confidence: 99%

Melatonin for sleep problems in children with neurodevelopmental disorders

2015

DTB

View full text Add to dashboard Cite

Children with neurodevelopmental disorders are at risk of sleep problems, typically difficulty getting to sleep, sleep/wake rhythm disturbances and reduced duration of sleep (insomnia). This may be associated with abnormally timed or inadequate secretion of melatonin, a naturally-occurring hormone involved in coordinating the body's sleep-wake cycle. Previously, we reviewed the use of a melatonin product licensed for primary insomnia in adults aged over 55 years. Here we review off-label and unlicensed use of melatonin in children with attention-deficit hyperactivity disorder (ADHD) or autism spectrum disorder or related neurodevelopmental disorders.

show abstract

Melatonin: An option for managing sleep disorders in children with autism spectrum disorder

Cited by 31 publications

References 28 publications

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

The use of melatonin in Swedish children and adolescents—a register-based study according to age, gender, and medication of ADHD

Melatonin for sleep problems in children with neurodevelopmental disorders

Contact Info

Product

Resources

About