Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Volpe, Antonio Della; Lucia, Andrea De; Pirozzi, C.; Pastore, Vincenzo

doi:10.5152/iao.2017.3054

Cited by 12 publications

(14 citation statements)

References 33 publications

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“…In a pilot study [ 140 ] on children aged 7 to 17 years, melatonin supplementation (“ME group”) was compared to melatonin + vitamin B6 + Trp supplementation (“MET group”): after two months of supplementation, a statistically significant reduction of the number of night awakenings was found in the “MET group”, but not in the “ME group”. Similar results were found by another study [ 141 ] conducted on a large sample of younger children (748 patients aged 12 to 48 months) that had to undergo audiologic testing requiring the child to be asleep. A solution containing melatonin, Trp and vitamin B6 proved to be significantly more effective than melatonin alone in reducing the number of tests that had to be repeated due to awakening of the child.…”

Section: Oral Over-the-counter Medicinessupporting

confidence: 88%

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

et al. 2020

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Autism Spectrum Disorders (ASD) are lifelong neurodevelopmental conditions characterized by abnormal social interaction, communication, and behavior. Sleep disturbances represent a common comorbidity in children and adolescents with ASD, with prevalence ranging from 50 to 80%. It has been proved that sleep disruption worsens the symptoms of autism and results in challenging behaviors. Improving sleep should therefore be a primary therapeutic goal. Treatment options range from lifestyle modifications to pharmacological therapy. Several reviews have been written on pharmacological treatments, but very few on the beneficial effects of non-pharmacological interventions, over-the-counter drugs, and nutritional supplements. This study consists of a narrative review of the literature, presenting the available evidence on the following treatments: sleep education, behavioral interventions, complementary and alternative medicine (special mattresses and blankets, massage, aromatherapy, yoga, physical activity), and commonly used over-the-counter medications and supplements (antihistamines, melatonin, tryptophan, carnosine, iron, vitamins, and herbal remedies). For some treatments—such as melatonin and behavioral interventions—effectiveness in ASD is well established in the literature, while other interventions appear of benefit in clinical practice, even if specific studies in children and adolescents with ASD are lacking. Conversely, other treatments only seem to show anecdotal evidence supporting their use.

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Section: Oral Over-the-counter Medicinessupporting

confidence: 88%

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

et al. 2020

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“…Three different dosages were tested: two different administration timings (pre-treatment and single shot treatment) and three dosages (0.5 ml, corresponding to 1 mg of melatonin, in pre-treatment, 1.5 ml, corresponding to 3 mg of melatonin, in pre-treatment, and 3 ml, corresponding to 6 mg of melatonin in single shot). The authors found a more rapid induction of sleep using pre-medication with 1.5 ml solution (3 mg of melatonin), with a reduction in the duration of the exam [19, 20].…”

Section: Discussionmentioning

confidence: 99%

A solution based on melatonin, tryptophan, and vitamin B6 (Melamil Tripto©) for sedation in newborns during brain MRI

et al. 2019

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Introduction Melatonin has been studied and used for several years as a sleep-wake cycle modulator in patients with sleep disorders. Experimental evidence has demonstrated the multiple neuroprotective benefits of this indoleamine secreted by the pineal gland. Melatonin is also used in neurological investigations, for its ability to induce sleep in children. In fact, it favors falling asleep during electroencephalogram, Magnetic Resonance Imaging (MRI), and during brainstem auditory evoked potentials. Previous studies are focused on infants and children. No investigation have been performed in neonates, before or during instrumental assessments. Material and methods One hundred ten newborns (term and preterm) undergoing brain MRI were enrolled in the study. Thirty minutes before the planned time for the examination, we administered a single dose solution of melatonin- tryptophan-vitamin B6. Twenty minutes after the initial administration of 2 mg, a second dose of 1 mg was administered, if the baby was still awake. If after further 15 min the baby was still not sleeping, an additional dose of 1 mg was administered. Results In 106 patients we obtained adequate sedation without adverse events, allowing us to perform an adequate quality MRI, with a median time of 25 min to reach sleeping. Only in three patients MRI could not be performed. In patients having a large weight, higher doses of melatonin were necessary to reach sleeping. Considering the pro kg dose of melatonin, the average dose that induced sleepiness in neonates was 0,64 ± 0.16 mg/Kg. Conclusion A solution based on Melatonin- tryptophan-vitamin B6 can be a helpful sedative to administer to neonates undergoing brain MRI, avoiding the use of anesthetics and achieving adequate assessments.

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“…Improvement in fatigue post pyridoxine may be linked to the fact that pyridoxine plays a vital role in haemoglobin-the protein that carries oxygen round the body-synthesis. Besides feeling tired from anemia, pyridoxine deficiency could also potentially contribute to tiredness due to its role in making the sleep-promoting hormone melatonin (25)(26).…”

Section: Discussionmentioning

confidence: 99%

The effect of pyridoxine supplementation on quality of life of patients with chronic lymphocytic leukaemia

Nwannadi¹,

Onoja²,

Anike³

et al. 2018

Research Journal of Health Sciences

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Objective: Pyridoxine, is essential in the metabolism of many classes of food, we aimed at determining the effect of its supplementation on the quality of life (QoL) of patients with chronic lymphocytic leukaemia (CLL). Methods: This study compared the (QoL) and haematological parameters of CLL patients before and after the administration of pyridoxine. Data obtained were analyzed using SPSS version 19. Results: There was improvement in the QoL of the patients after pyridoxine supplementation; Majority of the parameters that make up the physical functional scales was significantly higher after pyridoxine supplementation. There were also significant improvements in insomnia, appetite loss and constipation after pyridoxine supplementation. Conclusion: Pyridoxine supplementation in patients with CLL marginally improved quality of life.

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Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Cited by 12 publications

References 33 publications

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments

A solution based on melatonin, tryptophan, and vitamin B6 (Melamil Tripto©) for sedation in newborns during brain MRI

The effect of pyridoxine supplementation on quality of life of patients with chronic lymphocytic leukaemia

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