Melanotic neuroectodermal tumor of infancy: review of literature and case report

Selim, Heba; Shaheen, Shagufta; Barakat, Khaled; Selim, Abdulhafez

doi:10.1016/j.jpedsurg.2008.02.068

Cited by 43 publications

(36 citation statements)

References 14 publications

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“…This lesion has a well-circumscribed radiographic appearance within the bone (in the majority of cases) and presents with radiolucency, although aggressive examples with poor bone delimitation may be seen, as was shown in the present case [3,15]. The bone involved was destroyed, but we observed no well defined limits, thus suggesting a malignant process [3,16], that could be multilocular [17]. CT with intravenous contrast is frequently used to delineate the margins of bone involvement.…”

Section: Discussionsupporting

confidence: 57%

“…Because of their low occurrence, with approximately 360 cases described in the medical literature [1][2][3], this lesion has raised intense controversy with regard to its origin and pathophysiology. This tumor usually appears in children under the age of 1 year [4,5], with an approximately equal distribution between the sexes [4,6].…”

Section: Discussionmentioning

confidence: 99%

“…CT with intravenous contrast is frequently used to delineate the margins of bone involvement. Furthermore, the magnetic resonance image with gadolinium contrast could be used to evaluate the extent of the bone lesion [3,16].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, no tissue similar to that of the sclera was identified, and the eyes of these patients are generally normal. Therefore, the majority of authors believe that the tumor originates from neural crest cells [1,3,5,[8][9][10].…”

Section: Discussionmentioning

confidence: 99%

“…This treatment may be accompanied by a complete or partial maxillectomy, depending on the extent of the tumor, and the Weber Ferguson access or facial degloving may be used, when necessary [3]. Teeth and soft tissues adjacent to the lesion must be removed, to diminish the chance of recurrence.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Extensive Melanotic Neuroectodermal Tumor of Infancy

Albuquerque

Cunha

Avelar

et al. 2015

Head and Neck Pathol

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The melanotic neuroectodermal tumor of infancy (MNTI) is a rare childhood neoplasm with an alarming but classical clinical presentation. We present the case of a 2-month-old male infant treated with surgery for an aggressive MNTI on the alveolar process of the maxilla. Radiographic examination showed a diffuse osteolytic radiolucent lesion in the right maxilla, and displacement and dysmorphic changes in the developing primary tooth buds. The patient remained well without evidence of recurrence for 6 months after surgery. We discussed clinicopathological features, management alternatives, and outcome.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Extensive Melanotic Neuroectodermal Tumor of Infancy

Albuquerque

Cunha

Avelar

et al. 2015

Head and Neck Pathol

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Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report

et al. 2010

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We describe a rare case of melanotic neuroectodermal tumor (MNT) of the brain recurring 12 years after complete remission. An 11-year-old girl initially presented with exotropia and bilateral papilledema. Magnetic resonance (MR) imaging revealed an intracranial extraaxial large tumor at the midfrontal region. T(1)-weighted MR imaging showed the tumor to be well delineated with homogeneous enhancement by gadolinium. The tumor was subtotally removed, and the histological diagnosis was MNT. The residual tumor became enlarged, so gamma knife radiosurgery was performed 5 months after initial surgery. The enhanced lesion disappeared, but another lesion emerged 3 years later. A second gamma knife radiosurgery was performed for this local recurrence. The enhanced lesion disappeared once again. Twelve years after the second gamma knife radiosurgery, another local recurrence was detected. This tumor was subtotally removed. Histological examination confirmed the same diagnosis of MNT. This case suggests that MNTs not completely resected need long-term follow up, even if complete remission was achieved after adjuvant therapy.

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Melanotic neuroectodermal tumour of infancy: surgical and chemotherapeutic management

Pears

Kearns

2015

Ir J Med Sci

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Melanotic neuroectodermal tumour of infancy (MNTI) is a rare pigmented neoplasm of neural crest origin. It usually presents in the first year of life in the maxilla as a fast growing lesion. We describe the case of a 3-month-old boy who presented with an enlarging swelling of left maxillary alveolus. He was treated with combined surgical and chemotherapy modalities. MNTI is complicated by high recurrence rate, local invasion and malignancy has been reported. This report describes the diagnosis, treatment and follow-up of recurrent MNTI.

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Melanotic neuroectodermal tumor of infancy: review of literature and case report

Cited by 43 publications

References 14 publications

Extensive Melanotic Neuroectodermal Tumor of Infancy

Extensive Melanotic Neuroectodermal Tumor of Infancy

Melanotic neuroectodermal tumor of the brain recurring 12 years after complete remission: case report

Melanotic neuroectodermal tumour of infancy: surgical and chemotherapeutic management

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