Melanotic neuroectodermal tumour of infancy: surgical and chemotherapeutic management

C, Murphy; Pears, Jane; Kearns, Gerard

doi:10.1007/s11845-015-1323-4

Cited by 7 publications

(11 citation statements)

References 10 publications

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“…Neoadjuvant therapy is usually reserved for inoperable tumors, involvement of the central nervous system and other vital structures, or when clear surgical margins are not achievable. 7,[43][44][45] In a recent unpublished case at the University of Michigan, chemotherapy was successfully used after 3 failed attempts for complete surgical resection of a tumor with dural involvement. This patient was followed with physical exams and imaging, and has had no evidence of recurrence after 30 months of follow-up.…”

Section: Prognosis and Current Treatmentmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy

Soles¹,

Wilson²,

Lucas³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm. Objective.— To review its clinical presentation and immunomorphologic findings, and discuss common entities in the differential diagnosis. Data Sources.— The study involved PubMed searches, including multiple review articles, case studies, retrospective studies, selected book chapters, and University of Michigan cases. Conclusions.— Melanotic neuroectodermal tumor of infancy most commonly occurs in the bones of the head and neck region during the first year of life, but it can also present in other locations, including the central nervous system, testes, ovaries, and subcutaneous soft tissues. Histologically, it is composed of a biphasic population of cells, consisting of epithelioid melanin-producing cells and primitive neurogenic cells in a fibrocollagenous stroma. These microscopic findings, especially in small biopsies, can lead to a broad differential diagnosis that includes malignant small round blue cell tumors and malignant melanoma. Melanotic neuroectodermal tumor of infancy commonly has an infiltrative growth pattern, and anatomic constraints often lead to incomplete resection and local recurrence, requiring multiple surgical operations. Because melanotic neuroectodermal tumor of infancy can mimic a more aggressive and aggressively treated malignancy, recognition of this rare tumor is very crucial for pathologists.

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Section: Prognosis and Current Treatmentmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy

Soles¹,

Wilson²,

Lucas³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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“…Other authors describe associations with chemotherapy and radiotherapy regimens, but without an established protocol, differing between the moment and the scheme employed for each patient [16,19,21]. The challenge in managing cases such as the one in this report, in which the most commonly used therapy-surgery-becomes unfeasible, is due to the lack of a pattern in the administered regimens, most of them established on empirical administration based on therapies for other types of tumour.…”

Section: Discussionmentioning

confidence: 97%

The recurrence of the melanotic neuroectodermal tumour of infancy: an unusual presentation of a rare tumour

Pereira

Rozante

Doveinis

et al. 2020

ecancer

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The melanotic neuroectodermal tumour of infancy (MNTI), also known as melanotic progonoma, is a rare neoplasm derived from neural crest cells. Although it is fundamentally benign, the tumour may present a locally aggressive behaviour, characterised by a rapid progression and a destructive invasion of adjacent structures, hence causing deformities. Unfortunately, perhaps due to the low incidence of this type of tumour, the published cases in the literature do not characterise the factors that imply the malignant or recurrent behaviour of the disease, nor the therapy to conduct these cases. Here, we report a rare case of a recurrent benign MNTI, approached unusually with a favourable outcome.

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“…The rational for using neoadjuvant chemotherapy is to reduce the size of the tumor so that a more complete resection may be obtained. Neoadjuvant treatment is offered to patients with vital structure involvement or who may be 'inoperable' [37,38]. Chemotherapy has been proposed to induce the maturation of the neuroblast-like cells thus reducing this cell population and increasing the amount of epithelial cells [3].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Melanotic Neuroectodermal Tumor of Infancy and Review of the Literature

Jugmohansingh¹,

Medford²,

Sharma³

et al. 2020

AJSCR

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin that most commonly occurs in the first year of life. The craniofacial area is affected 90% of the time with the maxilla being the affected site in the majority of cases. It has a recurrence rate of up to 27% and is associated with malignant transformation in up to 6.5% of patients. The current case describes the clinical presentation and management of a 3-month old male infant with MNTI of the maxilla. Following initial presentation, the tumor grew rapidly to compromise the aerodigestive tract. Surgical resection was performed and the adjacent bone was burred. There has been no clinical recurrence over a 4-year period of follow up.

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Melanotic neuroectodermal tumour of infancy: surgical and chemotherapeutic management

Cited by 7 publications

References 10 publications

Melanotic Neuroectodermal Tumor of Infancy

Melanotic Neuroectodermal Tumor of Infancy

The recurrence of the melanotic neuroectodermal tumour of infancy: an unusual presentation of a rare tumour

A Case Report on Melanotic Neuroectodermal Tumor of Infancy and Review of the Literature

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