Melanotic Neuroectodermal Tumor of Infancy in the Epididymis

Abstract

We report a case of melanotic neuroectodermal tumor that originated in the right epididymis of a 4-month-old Japanese male and review reports of similar cases. Since we could not exclude malignant disease preoperatively, we performed a radical orchiectomy. Histopathological and immunohistochemical studies revealed features characteristic of a melanotic neuroectodermal tumor. Imaging studies showed no distant metastases.

Pigmentierter neuroektodermaler Tumor des Kindesalters

“…Lange Zeit wurde der Ursprung des Tumors diskutiert, was sich auch in den verschiedensten Namen wie "retinal anlage tumor", "pigmented congenital epulis","pigmented ameloblastoma","melanotic epithelial odontoma" oder "melanotic progroma" [9,15], die die Geschwulst im Lauf ihrer Erforschung erhalten hat, widerspiegelt. Berichtet wurde aber auch über das Auftreten an anderen Lokalisationen wie der Mandibula [11,21], verschiedenen anderen Schädelknochen [13,15,18,21], den Nebenhoden [13,16,20] oder den Extremitäten [13,22]. Prädilektionsort der Geschwulst sind die Kopf-und die Halsregion mit über 90% der Fälle, wobei die vordere Maxillaregion besonders häufig betroffen ist [7].…”

Melanocytic Neuroectodermal Tumour of Infancy of Testis - A rare Case Report

“…3 Melanotic neuroectodermal tuomr of infancy(MNTI) arising in testis is extremely rare. 4 Maximum number of cases developed in the first year of life and both sexes are affected equally. 5 Clinical courses is generally benign but local recurrence rate is 10-15% and metastasis have been documented in less than 5% cases.…”

Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling

“…1 MNTI is extremely rare in the epididymis and testis. To the best of our knowledge, only 24 cases in the epididymis [2][3][4][5][6][7][8][9] and 2 cases involving testicle 10,11 have been reported in the literature. Its rarity, and rapid and infiltrative growth pattern and variable histological features pose a diagnostic challenge.…”