Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling

Fabien-Dupuis, Corinthia; Niver, Benjamin E.; Shillingford, Nick; Wang, Larry; Kokorowski, Paul; Zhou, Shengmei

doi:10.1177/1093526616686437

Cited by 11 publications

(3 citation statements)

References 13 publications

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“…This could be triggered by the host human-immune and parasite interaction, leading to the clearance of acute infection, which could have led to chronic clinical disease (hydrocele and lymphoedema) observed. In Figure 5A, the scrotal enlargements in the younger age group (5-11 years) were not hydrocele, but rather a condition possibly triggered by other conditions, such as congenital inguinal hernias, which are frequently seen in this age group [47], tumors, or tuberculosis. In this age group, hydroceles were not as common as in individuals aged 16-24 years [24,29].…”

Section: Discussionmentioning

confidence: 93%

Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania

Fimbo

Minzi

Mmbando

et al. 2020

JCM

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Lymphatic filariasis (LF) is a neglected tropical disease targeted for elimination as public health problem through morbidity management and preventive annual mass drug administration (MDA). This cross-sectional community-based surveillance assessed the prevalence and correlates of LF infection in Mkinga district, Tanga-region, Tanzania. A total of 4115 individuals (49.7% males, 35.2% children) were screened for circulating filarial antigens (CFA), microfilaremia (mf) and disease manifestations in 15 villages between November 2018 and January 2019. MDA uptake in the previous year was assessed. Overall prevalence of CFA-positivity was 5.8% (239/4115; 95% CI: 5.1–6.6), with significant heterogeneity between villages (range 1.2% to 13.5%). CFA-positivity was higher in males (8.8%) than females (3.3%), and correlated with increasing age (p < 0.001). Prevalence of mf among CFA-positives was 5.2%. Only 60% of eligible inhabitants in the study area took MDA in the previous year, and CFA-positivity was 2-fold higher in those who missed MDA (p < 0.0001). Prevalence of scrotal enlargement, hydrocele, arms or legs swelling, lymphoedema and lymphadenopathy was 6.4%, 3.7%, 1.35%, 1.2% and 0.32%, respectively. Compared to baseline data, 16 years of MDA intervention significantly reduced LF transmission and morbidity, although the intended elimination target of <1% mf and <2% antigenemia to level where recrudescence is unlikely to occur by the year 2020 may not be attained. The finding of hotspots with ongoing transmission calls for intensified control measures.

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Section: Discussionmentioning

confidence: 93%

Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania

Fimbo

Minzi

Mmbando

et al. 2020

JCM

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“…2,3 It predominantly involves craniofacial sites in more than 90% of cases, and most commonly arises in the maxilla. 3,4 Rare, non-head and neck sites include epididymis, [5][6][7] testis, 8,9 ovaries, 10 and soft tissue and bones of the extremities. [11][12][13][14] The largest retrospective study 2 that reviewed 472 reported cases within the literature showed mainly maxillary involvement in 279 cases (62.2%), followed by the skull (70; 15%), mandible (35; 7%), male reproductive system (23; 5%), central nervous system (20; 4%), soft tissue (7; 1%), and female reproductive system (3; ,1%).…”

mentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy

Soles¹,

Wilson²,

Lucas³

et al. 2018

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Melanotic neuroectodermal tumor of infancy, albeit rare and generally regarded as benign, is an important tumor to recognize because of its rapid growth, potential for local recurrence, and small round blue cell morphology, which can lead to misdiagnosis of a malignant neoplasm. Objective.— To review its clinical presentation and immunomorphologic findings, and discuss common entities in the differential diagnosis. Data Sources.— The study involved PubMed searches, including multiple review articles, case studies, retrospective studies, selected book chapters, and University of Michigan cases. Conclusions.— Melanotic neuroectodermal tumor of infancy most commonly occurs in the bones of the head and neck region during the first year of life, but it can also present in other locations, including the central nervous system, testes, ovaries, and subcutaneous soft tissues. Histologically, it is composed of a biphasic population of cells, consisting of epithelioid melanin-producing cells and primitive neurogenic cells in a fibrocollagenous stroma. These microscopic findings, especially in small biopsies, can lead to a broad differential diagnosis that includes malignant small round blue cell tumors and malignant melanoma. Melanotic neuroectodermal tumor of infancy commonly has an infiltrative growth pattern, and anatomic constraints often lead to incomplete resection and local recurrence, requiring multiple surgical operations. Because melanotic neuroectodermal tumor of infancy can mimic a more aggressive and aggressively treated malignancy, recognition of this rare tumor is very crucial for pathologists.

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“…Testicular, rete testis, and spermatic cord involvement have been reported. 6,7 CT typically reveals a hyperdense mass, but hypodense growths also have been reported. On a magnetic resonance imaging, the tumor appears isointense or hypointense on T1- and T2-weighted sequence and shows a contrast enhancement after gadolinium injection.…”

Section: Discussionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report

et al. 2023

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin that predominantly involves the craniofacial region, involvement of the epididymis being extremely rare, with about 30 cases reported. We report an unusual case of a 5-month-old male with MNTI in the epididymis. The patient underwent orchiectomy. Half a year later, there was no sign of recurrence. Whether preoperative examination or intraoperative frozen examination, the tumor may easily be misdiagnosed as malignancy. Melanotic neuroectodermal tumor of infancy should be included in differential diagnosis in infants presenting with fast-growing scrotal swelling.

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Melanotic Neuroectodermal Tumor of Infancy Presenting With Fast-Growing Scrotal Swelling

Cited by 11 publications

References 13 publications

Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania

Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania

Melanotic Neuroectodermal Tumor of Infancy

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report

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