1989
DOI: 10.3109/01913128909051157
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Melanotic Neuroectodermal Tumor of Infancy Occurring in the Left Thigh of a 6-Month-Old Female Infant

Abstract: We report an exceptional case of melanotic neuroectodermal tumor of infancy (MNTI) occurring in the soft tissue of the left thigh of a 6-month-old female infant. The tumor consisted mainly of small round cells (neuroblasts) arranged in cords and nests that were separated by broad fibrovascular areas. In addition, there were a few medium-sized tumor cells containing melanin pigment (melanocytic cells) that in electron microscopy contained melanosomes as well as tonofilaments. Both tumor cell types immunostained… Show more

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Cited by 21 publications
(17 citation statements)
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“…Scattered isolated strands or pseudoglandular formations of pigmented epithelial cells or clusters of small cells may also be seen within the intratumoral stroma [545,552]. There may be significant variation in the degree of pigment generation, and sometimes melanin can be seen within the small cell component [542,548].…”
Section: Melanotic Neuroectodermal Tumor Of Infancymentioning
confidence: 99%
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“…Scattered isolated strands or pseudoglandular formations of pigmented epithelial cells or clusters of small cells may also be seen within the intratumoral stroma [545,552]. There may be significant variation in the degree of pigment generation, and sometimes melanin can be seen within the small cell component [542,548].…”
Section: Melanotic Neuroectodermal Tumor Of Infancymentioning
confidence: 99%
“…Although both cell types are immunoreactive for vimentin and neuron-specific enolase, they otherwise show different immunophenotypes. Whereas the large cells are also positive for cytokeratins and certain melanocytic markers (HMB45 and dopamine beta-hydroxylase), the small cell component is not [542,545,546,552]. S-100 protein expression is usually negative in both components, with focal expression observed in less than 10% of cases [542,545,546,552].…”
Section: Melanotic Neuroectodermal Tumor Of Infancymentioning
confidence: 99%
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“…In 1971, the World Health Organization designated this neo plasm 'melanotic neuroectodermal tumor of infancy' [26], While the genesis of MNTI is uncertain, several investiga tors found evidence of a neuroectodermal (neural crest) origin by biochemical, histochemical, ultrastructural and immunohistochemical analyses [1][2][3][4][5][6][7][8][9][10][11][12]. Proliferating cells in MNTI have unique and peculiar morphological charac teristics of neuroectodermal differentiation, making the precise identification of this disease possible by morpho logical study.…”
Section: Discussionmentioning
confidence: 99%
“…A neural crest origin has been suggested by the published histochemical, ultrastruc tural and immunohistochemical studies [1][2][3][4][5][6][7][8][9][10][11][12], Since its first description by Krompechcr [13] in 1918, about 200 cases of MNTI have been published. This tumor usually affects the lower parts of the face and skull, particularly the maxilla, although it has also originated in other sites, including the epididymis [6][7][8][9][10][11][12][14][15][16][17][18][19][20][21][22][23][24][25], thigh [4], femur [3], and foot [5]. The 4-month-old boy described here represents the 23rd reported case of MNTI involving the epididymis.…”
Section: Introductionmentioning
confidence: 99%