Melanotic neuroectodermal tumor of infancy (MNTI) of the head and neck: A French multicenter study

Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

“…We also observed that lesions was seen as a rapidly growing asymptomatic bluish swelling, which corroborates the information previously published in the literature. 11,14,21 We observed that radical surgery is the best treatment approach, consistent with other previous studies. 13,18 Histologically, the tumor consists of a biphasic population of small neuroblast-like cells and larger melaninproducing epithelioid cells arranged in an alveolar architecture, with cords and trabeculae intersected by dense fibroblastic stroma.…”

“…13,14 To the best of our knowledge, this In our study, we observed that MNTI of the jaw bones occurs with the highest frequency from the second to sixth months of life. 5,6,12 MNTIs of the head and neck are uncommon aggressive lesions and mainly affect the jaw bones.…”

“…3,8,14,20 In the current study, after exploring the best treatment modality, radical surgery was found to be the best treatment choice, although the Kaplain-Meier curve revealed that complete excision came a close second. 3,8,14,20 In the current study, after exploring the best treatment modality, radical surgery was found to be the best treatment choice, although the Kaplain-Meier curve revealed that complete excision came a close second.…”

“…The mean follow-up was 51.1 months, with 199 patients alive with no evidence of disease during follow-up and with 4 patients dying from FIGURE 5 Kaplan-Meier graphs showing statistically significant results for (A), age (P ≤ .0001); B, location (P = .0007); C, occurrence of lymph node metastasis (P ≤ .0001); D, treatment (P ≤ .0001); E, recurrence (P ≤ .0001); and F, metastasis (P = .0001). 14,24 Our logistic regression produced an odds ratio of death among patients older than 12 months that was 75 times higher than that for patients younger than 12 months old. Although we found that MNTI of the jaw bones has a good prognosis, 3,23,24 patients should be followed-up due to the possibility of recurrence or metastasis; after 20 and 12 months, respectively, the orbit was the site most affected by distant metastasis.…”

“…1,11,14,23 Our analysis demonstrated that surgery (complete excision and radical surgery) is important to reduce the possibility of recurrence. Our findings are consistent with those of other studies, which found that surgical treatment is essential for a good prognosis over long-term follow-up.…”