Mélanome malin primitif du col utérin : à propos d’un cas avec revue de la littérature

Evaluation of 6 Patients with Genital Melanoma from Onset of Symptoms to Death: Evaluate the Factors Affecting the Prognosis of the Disease

“…But in other studies that are initial studies of patients, examined population is often limited, as in our study. In some previous studies, vaginal bleeding was listed as the primary symptom of the patient ( 5 , 6 , 10 ). In previous studies the primary site of lesion associated with the period from onset of symptoms to diagnosis, prognosis and outcome, was not studied in this way.…”

“…Most of the lesions are discovered accidentally during a gynecological examination. Common symptoms are pain, bleeding, and vaginal discharge ( 5 , 6 ). When these lesions appear on the vulva, they can affect labia minor, labia major or clitoris.…”

“…As genital melanoma symptoms are similar to other disorders in this area, these patients often misdiagnoses for example as: genital infections, irregular menstruation or other malignancies in this area; and sometimes treatments are inappropriate ( 6 ). When they return because of the lack of response to treatment, and diagnosed with a closer evaluation, disease spread and evidence of invasion or metastasis can be seen.…”

Primary malignant melanoma of uterine cervix FIGO IIa1: A case report with 40months ongoing survival and literature review

“…It was only in 1959 when basal melanocytes were identified in cervical biopsies by Cid S.J. Melanocyte migration from neural crest or melanocytic differentiation from the endocervical epithelium are two theories for the presence of those melanocytes on the cervix (Zamiati et al, 2001). Risk factors such as HPV 16, radiotherapy or estrogen hormonal influence has been proposed as per case reports in the literature.…”

“…Cervical MM is highly aggressive as both local recurrence and wide spread metastases usually occur within a short span of a few months to two years from initial diagnosis (Zamiati et al, 2001). Relapse is more likely to be local (vagina, vulva or alongside suture line) rather than distant, stressing the value of clinical examination as part of routine follow-up.…”