Melanomas Arising in Large Congenital Nevocytic Nevi: A Prospective Study

Gari, Lorraine M.; Rivers, Jason K.; Kopf, Alfred W.

doi:10.1111/j.1525-1470.1988.tb01161.x

Cited by 80 publications

(21 citation statements)

References 25 publications

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“…[3][4][5][6][7][8][9] However, although the potential for melanoma development is not disputed, there is a lack of long-term observational study data indicating the true incidence of such malignant transformation. The available data suggest a ported, of which two were central nervous system melanomas and one was a retroperitoneal melanoma.…”

Section: Resultsmentioning

confidence: 97%

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Carbon Dioxide Laser Dermabrasion for Giant Congenital Melanocytic Nevi

Reynolds

Kenealy

Mercer

2003

Plastic and Reconstructive Surgery

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The management of giant congenital melanocytic nevi remains controversial. There is a balance to be achieved between minimizing the disfiguring appearance of these lesions, both before and after surgical treatment, and limiting the risk of malignant change. A series of seven patients who were treated in the same manner, with carbon dioxide laser dermabrasion, is presented. It has been 6 years since the first patient was treated in this way, and no cases of recurrence have been observed. This technique enables the removal of all or most of the pigmented lesion, with minimal scarring and without the need for disfiguring skin grafts. It has been well proved that there is an increased risk of malignant changes among patients with these lesions, although the amount of increased risk for the patient is not clear. Evidence from a review of the currently available literature is presented to indicate why this management method, at best, should decrease this risk and, at worst, should make no difference to the overall risk for individual patients.

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Section: Resultsmentioning

confidence: 97%

“…lifetime risk of malignant transformation of 2.0 to 8.5 percent [3][4][5][6][7][8][9]. Bittencourt et al8 recently published an upto-date review of the registry of large congenital melanocytic nevi maintained at the New York University School of Medicine, which was first established in 1979.…”

mentioning

confidence: 97%

Carbon Dioxide Laser Dermabrasion for Giant Congenital Melanocytic Nevi

Reynolds

Kenealy

Mercer

2003

Plastic and Reconstructive Surgery

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“…8,16,42,83,[91][92][93] At least 5 cases of rhabdomyosarcoma arising within CMN have also been reported, 94 small or medium sized ones, but more data are necessary before drawing conclusions d Studies with smaller numbers of patients may have suffered from selection bias and overestimated the risk of melanoma…”

Section: Looked At Cmnmentioning

confidence: 98%

Congenital melanocytic nevi: Where are we now?

Alikhan

Ibrahimi

Eisen

2012

Journal of the American Academy of Dermatology

129

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“…Physicians agree that an increased risk for the development of MM is associated with large CMN [25,26,27,28,29,30,31,32,33,34,35,36], the risk association with small and medium-sized CMN remaining controversial [1,37,38,39,40,41,42]. The incidence of MM arising in the context of large CMN ranges from 0.3 to 12.4% in different studies (table 1).…”

Section: Discussionmentioning

confidence: 99%

Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

Ingordo¹,

Gentile²,

Iannazzone³

et al. 2007

Dermatology

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Background: The prevalence of congenital melanocytic nevi (CMN) among newborns ranges between 0.2 and 6% in the worldwide literature. In the only available study from Italy the rate was 1% at birth and 1.4% at 2 years of age. Some surveys performed among samples of children and adolescents in other countries showed a prevalence which ranged from 1.4 to 4.4%. Additional data on the frequency in adults are not available. Objective: The aim of this study was to estimate the prevalence of CMN in a large sample of a young male Italian population, which is deemed to be representative of the general population of the same age and sex. Methods: The potential conscripts resident in the coastal regions of southern Italy, enlisted for the compulsory service in the Italian Navy, were called at the age of 18 to the Draft’s Council Medical Unit of the Italian Navy in Taranto to evaluate their psychophysical fitness to recruitment. All the subjects examined from September 2002 to March 2004 showing skin lesions evocative of CMN were referred by general practitioners of the Draft’s Council Medical Unit to the Department of Dermatology of the Italian Navy Hospital for confirming the diagnosis, which was based on the clinical features and the personal history. The confirmed cases were recorded in a predefined patient card, containing the main anamnestic and clinical data. Since the screening of small CMN in such a large sample of subjects was believed to be difficult, only CMN with a diameter ≧1.5 cm were recorded. Results: In 23,354 examined persons 157 CMN were diagnosed, with a prevalence of 0.67% (Bayesian 95% confidence interval 0.57–0.79); 126 (80.3%) CMN were medium-sized (≧1.5 and ≤19.9 cm in diameter), and 31 (19.7%) were large (≧20 cm in diameter). Three CMN (1.9%) were located on the face, 23 (14.6%) on the chest, 24 (15.2%) on the abdomen, 36 (22.9%) on the back, 48 (30.5%) on the lumbar area, 15 (9.5%) on the upper limb, 19 (12.1%) on the lower limb and 15 (9.5%) on the shoulder. No CMN was located on the head. In 19 cases (12.1%) ≧2 adjacent anatomical sites (shoulder/chest, shoulder/arm, etc.) were involved. In 73 moles (46.4%) terminal hairs were present. Eight CMN (5.1%) showed a zosteriform (i.e. segmental) feature. None of the examined subjects reported a personal history of malignant melanoma (MM), and no person with a history of MM was observed among all the enlisted men referred to the Department of Dermatology during the time of the study. Conclusion: The prevalence of CMN in the Italian young male general population is roughly in agreement with the rates detected in general populations from other European studies. The observations of this study also suggest that the risk of appearance of MM, at least in childhood and adolescence, is limited for medium-sized CMN.

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Melanomas Arising in Large Congenital Nevocytic Nevi: A Prospective Study

Cited by 80 publications

References 25 publications

Carbon Dioxide Laser Dermabrasion for Giant Congenital Melanocytic Nevi

Carbon Dioxide Laser Dermabrasion for Giant Congenital Melanocytic Nevi

Congenital melanocytic nevi: Where are we now?

Congenital Melanocytic Nevus: An Epidemiologic Study in Italy

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