Melanoma of the Anus Disguised as Hemorrhoids: Surgical Management Illustrated by a Case Report

Riet, M. van’t; Giard, R. W. M.; Wilt, J.H.W. De; Vles, Wouter J.

doi:10.1007/s10620-006-9485-6

Cited by 18 publications

(17 citation statements)

References 16 publications

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“…Malignant melanoma, a neoplasm of neuroectodermal origin, has the skin as its main primary site, although it may appear in other regions, such as retina, oral cavity, genitourinary tract and others 4,[6][7][8] . It occurs because the tumor transformation starts with the precursor cells of melanocytes (melanoblasts), which are present in the most varied types of epithelium, including the mucous surface 4,9 .…”

Section: Discussionmentioning

confidence: 99%

“…Right above the pectineal line is the transition zone, where both glandular and squamous cells are present. Melanocytes may appear in the three regions (rectum, anal canal and transition zone), although the occurrence of melanoma is more frequent in the transition zone and squamous epithelium [1][2][3][4][5][6][7][8] .…”

Section: Discussionmentioning

confidence: 99%

“…A polypoid lesion can be taken for a hemorrhoidal thrombus 1 and 15 to 40% of the lesions can be amelanotic, which does not contribute to easy detection. Some cases have been reported with incidental findings at the anatomopathological analysis of post-hemorrhoidectomy and lateral internal sphincterotomy specimens 6 . The coloproctological examination with inspection, rectal touch and proctoscopy is extremely important, as it provides data such as size, consistency, fixation and invasion of sphincter or adjacent structures 1 .…”

Section: Discussionmentioning

confidence: 99%

“…The dissemination can be local or via lymphatic or hematogenic pathways. In lymphatic dissemination, the lymph nodes most commonly affected are those from the inguinal, obturator, mesenteric and para-aortic chains 5,6,8 . In hematogenic dissemination, the most frequent sites are: liver, lungs, brain and bones.…”

Section: Discussionmentioning

confidence: 99%

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Anorectal melanoma: review of diagnosis and treatment based on a case report

Fillmann¹,

Fillmann²,

Fillmann³

et al. 2012

J. Coloproctol. (Rio J.)

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Anorectal Melanoma is a rare and very aggressive tumor that should be part of the range of differential diagnoses of colorectal diseases. Today, the main discussion on the topic is about the best treatment, whether it should be more conservative or more aggressive. In order to review the main points on the subject, the authors report a case of a patient treated at the Coloproctology Service at the São Lucas Hospital, PUCRS.
O melanoma anorretal é uma patologia de baixa frequência, porém de agressividade expressiva, devendo fazer parte da gama de diagnósticos diferenciais do Coloproctologista. A principal discussão sobre o tema versa hoje sobre a melhor forma de tratamento, seja mais invasivo ou mais conservador. A fim de revisar os principais pontos sobre o assunto, relataremos o caso de uma paciente atendida no Serviço de Coloproctologia do Hospital São Lucas da PUCRS

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anorectal melanoma: review of diagnosis and treatment based on a case report

Fillmann¹,

Fillmann²,

Fillmann³

et al. 2012

J. Coloproctol. (Rio J.)

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“…These relatively nonspecific symptoms may erroneously raise the suspicion of benign hemorrhoidal disease, leading to a delay in diagnosis. 29 Other diseases in the differential diagnosis include epidermoid carcinoma, basal cell carcinoma, adenocarcinoma, and other more unusual tumors such as anaplastic sarcoma, lymphoma, undifferentiated cylindrical cellular carcinoma, and metastasis from other primary sites (eg, breast). 1 The average duration of symptoms before diagnosis is between 4 and 6 months.…”

Section: Presentationmentioning

confidence: 99%

Anorectal Melanoma: Diagnosis and Treatment

Meguerditchian¹,

Meterissian²,

Dunn

2011

Diseases of the Colon &Amp; Rectum

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An increase in the incidence of anorectal melanoma has recently been noted in the United States. Anorectal melanoma is an uncommon and lethal condition, with a median survival of <20 months. Unfortunately, nonspecific symptoms also attributable to common and benign conditions (eg, hemorrhoids) cause significant delay in its diagnosis. Although it has not been validated by clinical trials, abdominoperineal resection has historically been the treatment of choice for this disease. However, for the past 2 decades, a lack of clear survival benefit has led to a shift toward less-mutilating wide local excisions. Controversy still exists regarding the benefit of radiation therapy and chemotherapy. Furthermore, the value of nodal surgery in anorectal melanoma is unclear. In this article, we review the history and current status of management of anorectal melanoma, with a particular focus on surgical controversies and challenges in optimizing survival.

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