Optimal surgical management strategy for treatment of primary anorectal malignant melanoma—a systematic review and meta-analysis

A rare case of a primary malignant anorectal melanoma

“…The review included a total of 303 patients. The authors observed that despite the slightly better 5-year survival rate of LE (32% vs 23%), a statistically significant reduction in recurrence was found in APR group (OR=0.15; 95% CI: 0.08-0.28, p<0.00001) 9 . Lei et al 11 analyzed 795 ARM patients from the USA Surveillance, Epidemiology, and End Results (SEER) database.…”

“…The surgical treatment decision (LE vs APR) should be individualized 9,10 . Temperley et al 9 performed a metaanalysis that included 10 studies and 303 patients. The main aim of the review was to compare LE and APR outcomes.…”

Anorectal melanoma

“…Many surgeons advocate for LE given the unclear benefit on outcomes for APR and the avoidance of colostomy to maintain quality of life for patients. Although it has been suggested that APR may have improved rates of local recurrence compared to LE, 19–21 other studies have found no difference in local recurrence rates 22,23 . Furthermore, several retrospective studies demonstrate no survival benefit for APR compared to LE, (Tables 2 and 3).…”

“…22,23 Furthermore, several retrospective studies demonstrate no survival benefit for APR compared to LE, (Tables 2 and 3). 2,[4][5][6][7][8][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] Thus, in the absence of any demonstrable survival benefit, APR is now discouraged for the treatment of anorectal melanoma whenever technically feasible.…”

Malignant anorectal melanoma. Importance of early detection and its prgnostic implications

“…Abstract Text The appearance of melanomas in the gastrointestinal tract is rare. However, it must be taken into account in the differential diagnosis of gastrointestinal neoplasms, since they are very aggressive tumors and their early detection is essential to be able to offer patients optimal treatment in the initial stages of the disease 1 2 3 .…”