Melanoma of Stomach

Khaliq, Abdul; Siddappa, Pradeep K.; Thandassery, Ragesh B.; Kochhar, Rakesh; Bhattacharya, Anish; Vaiphei, Kim; Singh, Kartar

doi:10.1007/s12029-011-9342-5

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…The criteria for diagnosing primary gastric melanomas includes: (i) a single melanoma lesion located in the stomach with proven pathology; (ii) no concurrent lesions in other sites of the body; (iii) no history of melanoma; (iv) disease-free survival of at least 12 months after curative surgery. 8,9 Although our patient satisfies (ii), (iii) and (iv) of the above criteria, this case is different from other published reports, as this patient presents with primary gastric melanoma that has resulted in a simultaneous, double tumor in the gastric wall. We formulate three hypotheses concerning whether these two melanomas are primary or metastatic.…”

Section: Discussioncontrasting

confidence: 91%

Surgically treated gastric melanoma of unknown primary: A case report from a 10‐year survivor

Takahashi

Sugita

Kagaya

et al. 2020

Pathology International

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We describe an extremely rare case of simultaneous double melanoma of the stomach with no other obvious primary source. The patient has survived for more than 12 years post-complete gastrectomy. The patient was a woman in her seventies who was referred for anemia by another clinic. Esophagogastroscopy revealed an ulcerated gastric tumor that was diagnosed as a gastrointestinal stromal tumor (GIST) by endoscopic biopsy. She was admitted to our hospital for further examination and treatment. Gastroscopy at our institution revealed two submucosal tumors in the gastric wall. Since no metastatic lesions were detected after systemic exploration, multiple GIST of the stomach was diagnosed, and a total gastrectomy was performed. Malignant melanoma was diagnosed in both lesions by a histopathological study of the resected stomach. The patient's postoperative progress was good, and thorough examination of the skin did not result in the discovery of any systemic neoplastic lesions which could be regarded as the source for the primary tumor. No anticancer treatments were used. The patient has survived, with no recurrence for over ten years postsurgery. Strong evidence is presented in this case for the diagnosis and treatment of gastric malignant melanoma.

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Section: Discussioncontrasting

confidence: 91%

Surgically treated gastric melanoma of unknown primary: A case report from a 10‐year survivor

Takahashi

Sugita

Kagaya

et al. 2020

Pathology International

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“…Sixteen per cent of patients with conjunctival melanoma have distant metastases after 5 years . Gastric melanoma has a median survival time of only 5 months, and a 5‐year survival of 0% . For melanomas in the respiratory tract, the gastrointestinal tract, the urinary tract, and the female genital tract, the 5‐year survival is less than 40% (Table ).…”

Section: Prognosismentioning

confidence: 99%

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Mikkelsen

Larsen

Buchwald

et al. 2016

APMIS

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Mucosal melanomas constitute 1.3% of all melanomas and they may develop in any mucosal membrane. Conjunctival melanomas (0.5/million/year) and melanomas in the sinonasal cavity (0.5/million/year) are the most common, followed by anorectal melanomas (0.4/million/year) and melanomas in the oral cavity (0.2/million/year). Anorectal melanoma occurs slightly more often in females, whereas oral melanoma has a male predilection. Mucosal melanoma most commonly develops in a patient's sixth or seventh decade of life, and no differences between races have been found except for sinonasal melanoma and conjunctival melanoma, which are very rare in Black people. The symptoms are not tumour-specific and are related to the organ system affected, and the disease is most often diagnosed at an advanced clinical stage. The diagnosis of a primary tumour is difficult, and metastatic cutaneous melanoma and choroidal melanoma must be excluded. Mutations in KIT are frequently found, while BRAF and NRAS mutations are rarely found - except in conjunctival melanomas that carry BRAF mutations. Mutations in the TERT promotor region are also found in mucosal melanomas. Complete surgical resection with free margins is the treatment of choice. The prognosis is poor, with the 5-year survival rate ranging from 0% (gastric melanoma) to 80% (conjunctival melanoma).

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“…As far as we know, the vast majority of gastrointestinal melanomas are metastases from skinderived lesions. However, we have found 12 cases of primary gastrointestinal melanoma in the literature (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

Primary gastric melanoma with pancreatic metastasis: a case report

Xiao

et al. 2021

Ann Palliat Med

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We report an extremely rare case of primary gastric melanoma with pancreatic metastasis. As far as we know, the concept of primary gastrointestinal melanoma is currently controversial, because there are very few reports of primary gastrointestinal melanoma. At the same time, isolated pancreatic metastases are also very rare. The patient was admitted to the hospital with a main complaint of decreased appetite, and then underwent gastroscopy and found a mass in the stomach. The mass was initially diagnosed as poorly differentiated adenocarcinoma following a gastroscopic biopsy. The patient underwent radical total gastrectomy, pancreatic body and tail resection, splenectomy, and Roux-en-Y esophagojejunostomy. After further immunohistochemical examination of the surgically removed tissue, malignant melanoma was diagnosed. The tumor cells were arranged in sheets or nests with infiltrating growth, the cell sizes were inconsistent, nucleoli were obvious, and melanin particles were seen in the cytoplasm of some cells. The tumor cells were positive for MITF and S-100. Detailed systemic and imaging examinations did not find any other primary lesions. The patient denied any melanoma and skin lesion history. We believe this is a manifestation of primary gastric melanoma. We report this rare case of gastric melanoma with the aim of increasing clinicians' awareness of non-cutaneous melanoma and its treatment methods.

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Melanoma of Stomach

Abstract: Melanoma of stomach is rare. It has characteristic endoscopic appearance. Differentiation of primary from secondary melanoma is possible on clinical behavior and histological characteristics.

Cited by 11 publications

References 11 publications

Surgically treated gastric melanoma of unknown primary: A case report from a 10‐year survivor

Surgically treated gastric melanoma of unknown primary: A case report from a 10‐year survivor

Mucosal malignant melanoma – a clinical, oncological, pathological and genetic survey

Primary gastric melanoma with pancreatic metastasis: a case report

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