Melanoma mortality in Brazil: trends and projections (1998-2032)

Santos, Camila Alves dos; Souza, Dyego Leandro Bezerra de

doi:10.1590/1413-81232018244.13932017

Cited by 20 publications

(27 citation statements)

References 26 publications

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“…Data correction 26 is therefore required for a better estimation 23 , 24 , 27 . This study applies a correction to improve the reliability of data, based on a method available at the DATASUS website 28 . According to this method, redistribution of data by sex and age were employed for the correction procedure, along with adjustments regarding the completeness of death records.…”

Section: Methodsmentioning

confidence: 99%

“…The difference in percentage terms was calculated in relation to the number of deaths notified to SIM. These data, however, are only available from Chapter IX of ICD-10 and enable the formulation of the correction factor for the ICD factor 28 .…”

Section: Methodsmentioning

confidence: 99%

“…The factor was calculated for the period 2001–2013, according to the equation: 1 + [(redistributed deaths – notified deaths to SIM)/notified deaths to SIM]. Due to the unavailability of data for the period 2014–2015, the 2013 data correction factor was applied 28 .…”

Section: Methodsmentioning

confidence: 99%

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Reduction of mortality and predictions for acute myocardial infarction, stroke, and heart failure in Brazil until 2030

Siqueira

Souza

2020

Sci Rep

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Cardiovascular diseases (CVD) are responsible for the majority of deaths in Brazil and worldwide, and constitute an important share of non-transmissible diseases. The objective of this study is to analyze the mortality trends of the three main CVD in Brazil and its geographic regions: acute myocardial infarction, stroke, and heart failure. Data predictions until 2030 were also carried out. An ecological study is presented herein, with data for the period 2001–2015. Mortality from these diseases was evaluated by annual trends, and grouped in five-year intervals for the predictions until 2030. All data are publicly available. Acute myocardial infarction was the leading isolated cause of death. Brazilian trends revealed a decrease in the three diseases, with different patterns across geographic regions. The Southeast, South, and Midwest regions presented reductions for the three diseases. The predictions indicated higher rates for men. There was also a reduction in the risk of death from these diseases for Brazil and, despite the different mortality patterns for the three diseases, the Southeast region presents, primarily, lower predicted rates than the other regions. The assessment of trends and predictions for the three main CVD in Brazil revealed general decreasing trends with differences across the geographic regions.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Reduction of mortality and predictions for acute myocardial infarction, stroke, and heart failure in Brazil until 2030

Siqueira

Souza

2020

Sci Rep

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“…O objetivo deste estudo foi analisar a tendência temporal da mortalidade por câncer de fígado e vias biliar intra-hepáticas e projetar o número de óbitos até 2030 para o Brasil. Foi calculado o fator de correção para cada faixa etária 13 , período, Região e sexo, a partir da diferença em percentual entre a quantidade de óbitos notificados ao SIM e a de óbitos redistribuídos, baseado no Capítulo II (Neoplasias) da CID-10. Tal diferença foi expressa em valores decimais com o valor 1 correspondendo a uma mudança de 100%, por exemplo, existindo a possibilidade de valores maiores, visto que, em algumas localidades, o valor redistribuído representou valores acima daqueles registrados no SIM.…”

Section: Introductionunclassified

Mortalidade por Câncer de Fígado e Vias Biliares no Brasil: Tendências e Projeções até 2030

Santos

Fernandes

Santos

et al. 2020

Rev. Brasileira.De.Cancerologia

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Introdução: A neoplasia de fígado e vias biliares intra-hepáticas é a sétima mais incidente e representa a segunda maior causa de morte por câncer no mundo. Sendo assim, é crucial compreender a epidemiologia dessa doença, no que diz respeito às tendências temporais da mortalidade e da carga que essa doença apresentará no futuro. Objetivo: Analisar a tendência da mortalidade por câncer de fígado e vias biliares no Brasil e calcular as projeções de mortalidade até 2030. Método: Estudo ecológico baseado em óbitos por neoplasia maligna de fígado e vias biliares intra-hepáticas (C22) ocorridos no Brasil no período de 2001 a 2015 e registrados no Sistema de Informação sobre Mortalidade. As tendências de mortalidade foram analisadas pela regressão Joinpoint; para o cálculo das projeções, foi utilizado o programa Nordpred. Resultados: Para o sexo feminino, houve redução das taxas de mortalidade nas Regiões Centro-Oeste, Sudeste e Norte no Brasil; para o sexo masculino, essas Regiões apresentaram tendências de aumento, porém não significativo. As taxas de mortalidade para o sexo feminino apresentarão reduções no futuro, com destaque para as taxas das Regiões Norte e Nordeste, com redução de cerca de 30% até 2030. Para o sexo masculino, haverá acréscimo de 12% nas taxas de mortalidade para a Região Sul. Conclusão: A mortalidade por câncer de fígado e vias biliares no Brasil apresenta tendência de redução para o sexo feminino e estabilidade para o sexo masculino, e essa característica será mantida nas próximas décadas.

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“…Currently, the clinical treatments for melanoma are mainly surgical resection, systemic treatment, radiotherapy-based combined treatment, radiotherapy alone, and immunotherapy[3-5]. Relevant reports show that although good efficacy can be obtained by radical surgery in the early stage, it is difficult to treat malignant melanoma patients with metastasis or diffusion in the late stage, and there are still a large number of melanoma patients with recurrence or poor prognosis, which is also the reason for the high mortality of melanoma[6,7]. Analysis of the pathogenesis of human melanoma and inhibition of melanoma progression are an important part of melanoma research[8].…”

Section: Introductionmentioning

confidence: 99%

Expression and predictive value of miR-489 and miR-21 in melanoma metastasis

Guan

Yuan

et al. 2019

WJCC

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BACKGROUNDMelanoma is a highly malignant skin tumour, and is one of the most rapidly growing malignant tumors in recent years. According to statistics, the morbidity of cancer increases with age, accounting for 1.6% of new cancer cases and 0.6% of deaths worldwide. Melanoma has a serious impact on society and families, thus it is of great significance to find biological markers related to the diagnosis and treatment of melanoma.AIMTo explore the expression and predictive value of mir-489 and mir-21 in melanoma metastasis.METHODSA total of 60 patients with malignant melanoma treated at our hospital from June 2017 to December 2018 were selected as a research group, while 40 healthy subjects were selected as a control group. qRT-PCR technique was used to detect miR-489 and miR-21 in serum of the two groups. ROC curve was drawn to evaluate the predictive value and diagnostic efficiency. Spearman test was used for correlation analysis. Logistic single- and multiple-factor analyses were performed to identify the risk factors related to melanoma metastasis.RESULTSThe expression of miR-489 in the research group was significantly lower than that in the control group (P < 0.001). However, the expression of miR-21 in the research group was significantly higher than that in the control group (P < 0.001). The expression of miR-489 and miR-21 was related to TNM stage and metastasis (P < 0.001). In the diagnosis of melanoma patients, the sensitivity, specificity, and AUC of miR-489 alone were 75.56%, 80.00%, and 0.852, respectively. The sensitivity, specificity, and AUC of miR-21 alone were 77.78%, 82.22%, and 0.844, respectively. MiR-489 was negatively correlated with TNM stage of melanoma (r = -0.612, P < 0.001), while miR-21 was positively correlated with TNM stage (r = 0.609, P < 0.001). Logistic single- and multiple-factor regression analyses showed that TNM stage, miR-489, and mir-21 were independent risk factors for malignant melanoma metastasis.CONCLUSIONMiR-489 and miR-21 may participate in the process of melanoma occurrence, development, and metastasis, and can be used as potential serum biomarkers for melanoma metastasis diagnosis and disease assessment.

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Melanoma mortality in Brazil: trends and projections (1998-2032)

Cited by 20 publications

References 26 publications

Reduction of mortality and predictions for acute myocardial infarction, stroke, and heart failure in Brazil until 2030

Reduction of mortality and predictions for acute myocardial infarction, stroke, and heart failure in Brazil until 2030

Mortalidade por Câncer de Fígado e Vias Biliares no Brasil: Tendências e Projeções até 2030

Expression and predictive value of miR-489 and miR-21 in melanoma metastasis

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