Melanoma in the Italian Population and Regional Environmental Influences: A National Retrospective Survey on 2001–2008 Hospitalization Records

Piscitelli, Prisco; Neglia, Cosimo; Falco, Andrea; Rivezzi, Matteo; Agnello, Nadia; Argentiero, Alberto; Chitano, Giovanna; Distante, Chiara; Rosa, Giulia Della; Vinci, Giorgia; Donno, Antonella De; Distante, A.; Romanini, Antonella

doi:10.3390/ijerph120809102

Cited by 8 publications

(8 citation statements)

References 25 publications

(27 reference statements)

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“…Due to the low incidence of melanoma in Italy (13.5 cases/year over 100,000 inhabitants) [ 32 ], for a general population screening to be cost-effective, the following requirements should be fulfilled: a good uptake rate, a practical and accurate method for identifying the target population, and a selection of a target population that ensures a high yield of melanoma diagnosis [ 25 , 33 ]. Thus far, no unique scoring system has been developed to discriminate high-risk vs. low-risk individuals with respect to melanoma development.…”

Section: Discussionmentioning

confidence: 99%

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Dubbini¹,

Puddu²,

Salimbeni³

et al. 2021

IJERPH

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Background: Guidelines recommend limiting melanoma screening in a population with known risk factors, but none indicates methods for efficient recruitment. The purpose of this study is to compare three different methods of recruiting subjects to be screened for melanoma to detect which, if any, is the most efficient. Methods: From 2010 to 2019, subjects were recruited as follows: (1) regular skin examinations (RS), mainly conducted through the Associazione Contro il Melanoma network; (2) occasional melanoma screening (OS), during annual public campaigns; (3) and selective screening (SS), where people were invited to undergo a skin check after filling in a risk evaluation questionnaire, in cases where the assigned outcome was intermediate/high risk. Melanoma risk factors were compared across different screening methods. Generalized Linear Mixed Models were used for multivariable analysis. Results: A total of 2238 subjects (62.7% women) were recruited, median age 44 years (2–85), and 1094 (48.9 %) records were collected through RS, 826 (36.9 %) through OS, and 318 (14.2 %) through SS. A total of 131 suspicious non-melanoma skin cancers were clinically diagnosed, 20 pathologically confirmed, and 2 melanomas detected. SS performed significantly better at selecting subjects with a family history of melanoma and I-II phototypes compared to OS. Conclusions: Prior evaluation of melanoma known risk factors allowed for effective selection of a population to screen at higher risk of developing a melanoma.

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Section: Discussionmentioning

confidence: 99%

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Dubbini¹,

Puddu²,

Salimbeni³

et al. 2021

IJERPH

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“…Melanoma has a rate of 22.0 in males and 18.3 in females per 100,000/year (standardized for European population) in Italy (15), and higher incidence rates (32.5/100,000/year in males; 23.7/100,000/year in females) have been recorded in Friuli Venezia Giulia (FVG) (15), a Region located in Northeast Italy at the border with Austria and Slovenia. The incidence of melanoma in Italy shows an increasing trend (15), Northeast Italy has the highest prevalence of melanoma (16), and the FVG Region has the highest rate of hospitalization for melanoma in Italy (17).…”

Section: Introductionmentioning

confidence: 99%

Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma

et al. 2019

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Immunity and cytokines serve crucial roles in cutaneous melanoma. The present study investigated whether a variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor antagonist (IL-1RA) gene (IL-1RN) located in intron 2 (rs2234663) is associated with cutaneous melanoma. A total of 515 subjects were studied, 133 of which were cutaneous melanoma cases (72 stage I+II non-metastatic melanoma cases and 61 stage III+IV metastatic melanoma cases), and 382 subjects were matching healthy controls from the Friuli-Venezia-Giulia Region located in Northeast Italy, an area with a high melanoma incidence. The IL-1RN-VNTR polymorphism was determined by DNA fragment length analysis following PCR amplification. According to the number of 86-bp repeats, five different IL-1RN alleles were identified: Allele 1 (4-repeats), allele 2 (2-repeats, short allele), allele 3 (5-repeats), allele 4 (3-repeats) and allele 5 (6-repeats). Alleles with three or more 86-bp repeats, i.e. allele 1, 3, 4 and 5 were collectively denoted as long (L) repeats. The present study revealed that IL-1RN-VNTR 1/2 and 2/L genotypes were more frequent among patients with cutaneous melanoma (43.6 and 45.1%, respectively) compared with healthy controls [29.6 and 30.6%, respectively; odds ratio (OR), 1.84; CI, 1.22-2.77; P=0.003; and OR, 1.66; CI, 1.24-2.79; P=0.002, respectively]. Conversely, the IL-1RN-VNTR 1/1 genotype was less frequent among melanoma cases (45.9%) compared with healthy controls (57.9%; OR, 0.62; CI, 0.41-0.92; P=0.017). Comparison of metastatic vs. non-metastatic melanoma cases identified no significant differences. The present study first demonstrated that carriage of the 1/1 IL-1RN-VNTR genotype was protective, whereas 1/2 and 2/L was a risk factor for patients with cutaneous melanoma vs. healthy controls. The short allele 2 was associated with higher expression levels of IL-1RA, a potent competitive inhibitor of the proinflammatory cytokines IL-1α and IL-1β. VNTR-IL-1RN polymorphism may affect susceptibility to melanoma and, thus, it is a potential novel diagnostic biomarker for melanoma. The present study increased the understanding of genetic melanoma susceptibility/carcinogenesis, and may indicate novel strategies in the personalized prevention of cutaneous melanoma.

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“…O predomínio do MC quanto ao sexo não é concorde na literatura. Maior prevalência do MC em pacientes do sexo feminino ocorre em países como a Alemanha e Itália 8,21,22 , mas difere dos Estados Unidos 10 e países da Oceania 5,6 onde há o predomínio em pacientes do sexo masculino. Esses, por sua vez, seguem o mesmo padrão da Inglaterra 23 , país que originalmente contribuiu com a imigração dessas localidades.…”

Section: Métodosunclassified

Análise de prevalência e mortalidade associada ao melanoma cutâneo em pacientes atendidos em centro de referência no Oeste do estado de Santa Catarina, Brasil, de 2002 a 2016

et al. 2020

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Objetivo: determinar a epidemiologia e as características clínicas do melanoma cutâneo (MC) na região Oeste do estado de Santa Catarina, Brasil. Métodos: este estudo transversal e descritivo avaliou o comportamento clínico e o perfil epidemiológico do MC em pacientes de 78 municípios do Oeste do Estado de Santa Catarina, Brasil, no período de 2002 a 2016, tratados no Sistema Único de Saúde. Para a análise dos dados foi utilizado o teste do Qui-quadrado. Para elaborar as curvas de sobrevida, foi considerado um período de 10 anos (teste Log Rank). Resultados: dados de 1.146 pacientes foram avaliados, e houve uma média de 20 casos/100.000 habitantes/ano. Encontravam-se nos estágios I e II 63,5% dos pacientes. A sobrevida global em 10 anos de acompanhamento foi de 89%(IC95% 87,7% - 91,5%). Pacientes do sexo feminino apresentaram maior sobrevida (94,5%; IC95% 92,7% - 96,4% vs. 82,6%; IC95% 78,9% - 86,3%; p < 0,001) e variáveis de melhor prognóstico. Conclusões: o Oeste do estado de Santa Catarina apresentou uma alta prevalência de MC. As características clínicas e epidemiológicas encontradas concordam com as descritas nas populações que residem em regiões geográficas equivalentes; mas diferem de outras regiões do Brasil. Essas diferenças, associadas à organização do sistema público de saúde de referência e contra-referência, podem explicar aos resultados de sobrevida encontrados.

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Melanoma in the Italian Population and Regional Environmental Influences: A National Retrospective Survey on 2001–2008 Hospitalization Records

Cited by 8 publications

References 25 publications

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma

Análise de prevalência e mortalidade associada ao melanoma cutâneo em pacientes atendidos em centro de referência no Oeste do estado de Santa Catarina, Brasil, de 2002 a 2016

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