Melanoma Antigens and Their Association with Malignant Transformation and Tumor Progression

Johnson, Judith P.; Stade, Barbara; Rothbächer, Ute; Lehmann, Jürgen; Riethmüller, Gert

doi:10.1007/978-3-642-74496-9_9

Cited by 6 publications

(5 citation statements)

References 42 publications

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“…This result is in agreement with previous observations, which indicated that the presence of lymphohistiocytes around melanoma cells is associated with a good prognosis, representing the host response to developing neoplasia 37–40. It has been suggested that T lymphocytes and macrophages, attracted by a change in the tumor‐associated antigens, exert a protective role possibly through inhibitory growth factors secreted by suppressor/cytotoxic CD8 + cells 41, 42. To be of prognostic value, numerous inflammatory cells should be present and should be distributed at the periphery as well as in the context of the melanoma.…”

Section: Discussionsupporting

confidence: 92%

Thin cutaneous malignant melanomas (?1.5 mm)

Massi

Franchi

Borgognoni

et al. 1999

Cancer

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BACKGROUND Although thin cutaneous melanomas generally have a favorable prognosis, in some cases they may undergo progression. The current study was undertaken to identify variables that may predict a more aggressive clinical outcome in these patients. In addition to classic clinicopathologic features, the authors tested the prognostic impact of three new morphometric quantitative parameters: 1) tumor thickness plus regression thickness (T+R), 2) percentage of skin thickness infiltrated by tumor cells (T/S ratio), and 3) percentage of skin thickness infiltrated by tumor cells and regression ([T+R]/S ratio). METHODS The authors retrospectively evaluated 287 patients with invasive cutaneous melanoma ≤ 1.5 mm in thickness. Disease free survival rates (Kaplan–Meier method) were compared by using the log rank test. A multivariate analysis (Cox proportional hazards model) was used to determine the independent effect of each variable on progression. Progression was defined as any documented cutaneous local and/or distant metastasis. RESULTS Thirty‐two of the 287 patients (11.1%) underwent disease progression. The overall 5‐year and 10‐year disease free survival rates were 89.3% and 84.6%, respectively. In the univariate analysis, the following factors were found to be significant predictors of progression: male gender (P = 0.01), acral‐lentiginous histotype (P = 0.02), tumor thickness (P = 0.005), T+R (P = 0.001), T/S ratio ≥ 50% (P = 0.03), (T+R)/S ratio ≥ 50% (P = 0.006), vertical growth phase (P = 0.04), and absence of inflammatory response (P < 0.0001). Conversely, age, site, and Clark's level did not affect the risk of recurrences and/or metastases significantly. In the multivariate analysis, only T+R (P = 0.009) and inflammatory response (P < 0.0001) were found to be independent predictors of progression. Five‐year disease free survival rates according to presence versus absence of inflammatory response were 93.4% and 63.8%, respectively (P < 0.0001). CONCLUSIONS In the current study, peritumoral and intratumoral inflammatory infiltrate and T+R were found to be strong independent predictors of progression in thin cutaneous melanomas. Cancer 1999;85:1067–76. © 1999 American Cancer Society.

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Section: Discussionsupporting

confidence: 92%

Thin cutaneous malignant melanomas (?1.5 mm)

Massi

Franchi

Borgognoni

et al. 1999

Cancer

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“…The use of murine monoclonal antibodies to search for molecules which are expressed by human malignant melanoma cells but not by melanocytes in the benign proliferative precursor lesions has led to the identification of a number of molecules whose expression characterizes the various stages in the development of this tumor [26,27]. One of the molecules which was identified by this approach is MUC18, a cell surface glycoprotein of apparent molecular weight of 113 kd [28].…”

Section: Muc18-de Novo Expression Of a Putative Cam Is Associated Witmentioning

confidence: 99%

Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease

Johnson¹

1991

Cancer Metast Rev

135

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Cell adhesion molecules (CAMs) of the immunoglobulin supergene family may play important roles in tumorigenesis and the development of metastatic disease. In a variety of human malignancies, tumor progression has been observed to be associated with changes in CAM expression. An early event in colorectal tumorigenesis appears to be the down regulation of a normally expressed CAM, DCC. Over-expression of a second CAM, carcinoembryonic antigen, is associated with colorectal tumors which have a high risk for metastasis development. Several tumors, including Wilms tumors and neuroblastoma, have been found to express a developmentally regulated form of NCAM which inhibits a variety of cell-cell interactions. Malignant cells not only show aberrations in the expression of their CAMS and thus their normal cell-cell interactions, but establish new adhesive interactions. The development of metastatic potential in cutaneous melanoma is associated with the de novo expression of two CAMs, one of which is ICAM-1, a molecule mediating adhesion between the tumor cells and leukocytes.

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“…Immunohistochemical analysis of in situ phenotypic changes correlating with tumor progression in human cutaneous melanoma has led to the identification of molecules potentially involved in metastasis (1,2). One of these is the melanoma-associated antigen P3.58, an 89-kDa cell surface glycoprotein (3), that is not detectable on quiescent melanocytes and is only sporadically found on proliferative benign melanocytic lesions (i.e., nevi).…”

mentioning

confidence: 99%

De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis.

Johnson¹,

Stade²,

Holzmann³

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

301

159

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The 89-kDa cell surface glycoprotein, P3.58, is detectable on advanced human melanomas in situ but not on benign melanocytes or early melanomas. cDNA cloning of P3.58 from melanoma cells was accomplished by screening a A zap expression vector library with monoclonal antibodies produced against the denatured antigen. Nucleotide sequencing of the clones revealed that P3.58 is identical to the intercellularadhesion molecule 1. No qualitative differences in P3.58 mRNA species could be seen between melanoma cells and hematopoietic cells and no differences in gene organization were observed between peripheral blood leukocytes and melanoma cells. Inspection of the deduced amino acid sequence of P3.58 indicated the presence of the consensus sequence characteristic for complement-binding proteins. The acquisition of this cell-adhesion molecule during the process of tumor progression is speculated to contribute to the development of metastasis in melanoma.

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Melanoma Antigens and Their Association with Malignant Transformation and Tumor Progression

Cited by 6 publications

References 42 publications

Thin cutaneous malignant melanomas (?1.5 mm)

Thin cutaneous malignant melanomas (?1.5 mm)

Cell adhesion molecules of the immunoglobulin supergene family and their role in malignant transformation and progression to metastatic disease

De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis.

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