Melanoma and Non-Melanoma Skin Cancer Associated with Angiotensin-Converting-Enzyme Inhibitors, Angiotensin-Receptor Blockers and Thiazides: A Matched Cohort Study

Abstract

A safety signal for ACEIs, ARBs, and TZs and BCC and SCC, as well as for TZs and MM, was detected. An increased awareness and education, especially for those who are at high risk for skin cancer, are warranted for patients and healthcare providers. Further exploration of such associations for these commonly used drug classes is warranted.

Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma

“…Results of previous studies of ADs and the risk of skin cancer have been inconsistent . While some have shown increased risk with the use of potassium‐sparing and combination diuretics, but not loop or thiazide diuretics, several studies, including one at KPNC, have shown a significant association between thiazide diuretic use and increased SCC risk .…”

Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro

“…Phototoxic DNA damage was proven on human keratinocytes in vitro [43]. Several case studies demonstrated an enhanced sensitivity to sunlight and sunburn-like effects on patients treated with HCTs [41, 44]. In addition, the increase in photosensitivity leads to an enhanced risk of developing skin cancer and melanoma [42, 44].…”

“…Several case studies demonstrated an enhanced sensitivity to sunlight and sunburn-like effects on patients treated with HCTs [41, 44]. In addition, the increase in photosensitivity leads to an enhanced risk of developing skin cancer and melanoma [42, 44]. Because the HCT-induced downgraded threshold of DNA damage seemed to be the leading effect of this substance, wound healing should prospectively be analyzed under application of ultraviolet light.…”

Use of antihypertensive drugs and risk of keratinocyte carcinoma: A meta‐analysis of observational studies

“…Of 2430 unique citations retrieved from electronic databases, 9 studies met the eligibility criteria . Additionally, the data of one conference abstract were updated in 2017; thus, we included the latest study . Finally, we included 10 observational studies, ie, 6 cohort studies and 4 case‐control studies (Figure ).…”