Use of antihypertensive drugs and risk of keratinocyte carcinoma: A meta‐analysis of observational studies

Abstract

Current evidence indicates that use of diuretics might be associated with increased risk of KC, while ACE inhibitors or ARBs might be associated with decreased risk in high-risk individuals. β-blockers or CCBs might be positively associated with BCC risk. Further postmarketing surveillance studies and investigations to clarify the possible underlying mechanisms are warranted.

Voriconazole exposure and risk of cutaneous squamous cell carcinoma among lung or hematopoietic cell transplant patients: A systematic review and meta-analysis

“…35 Photosensitizing medications (e.g., diuretics) were found to be more strongly associated with SCC than BCC. 36 Therefore, it was not surprising that our study found no association between voriconazole and BCC, though this might also be falsely negative due to the inclusion of only two studies. In addition, it should be noted that we observed a significant increase in the risk of SCC, regardless of whether a study adjusted for sun exposure.…”

Photosensitizing antihypertensive drug use and risk of cutaneous squamous cell carcinoma

“…To our knowledge, the present study is the first to examine cSCC risk associated with the use of alpha blockers and central agonists. A recent meta‐analysis of observational studies examining the use of ADs and risk of keratinocyte carcinoma found that diuretics are associated with increased SCC risk, while ACE inhibitors and ARBs are associated with decreased SCC risk in high‐risk individuals, and CCBs and beta blockers are not associated with SCC risk …”

“…A recent meta-analysis of observational studies examining the use of ADs and risk of keratinocyte carcinoma found that diuretics are associated with increased SCC risk, while ACE inhibitors and ARBs are associated with decreased SCC risk in high-risk individuals, and CCBs and beta blockers are not associated with SCC risk. 27 The chemical structures of photosensitizing drugs permit the absorption of UVR, 8-10 the primary risk factor for SCC. 28 They promote sunburn and may be carcinogenic, triggering phototoxic or photoallergic reactions.…”

European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 1. epidemiology, diagnostics and prevention

“…A meta-analysis by Gandini et al reported no association between thiazide diuretics and cSCC [69]. While a positive association was reported in the meta-analysis of Tang et al, there was no association noted between thiazide use and cSCC risk when only studies that had accounted for sun exposure were included [70].…”