Melanom und Atopie

Kölmel, K. F.; Compagnone, Domenico

doi:10.1055/s-2008-1067613

Cited by 17 publications

(5 citation statements)

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“…When matched for important melanoma confounders (sunburn sensitivity, hair colour, number of moles, sunburn as juvenile, ever sunbed use, familial melanoma), age and sex, negative associations with melanoma development were observed for all 5 variables referring to atopy. This observed inverse association between atopy and melanoma is in line with previous literature which also found a lower risk of melanoma in atopics (4,9,10,12,17). In our study the correlation was only significant for personal atopy and we have to acknowledge that a strong claim about this correlation is not possible in the absence of a correction for multiple testing.…”

Section: Discussionsupporting

confidence: 89%

“…These studies examined the incidence of melanoma in AD vs. non-AD subjects, but did not take other melanoma risk factors into account. Three other studies comparing the incidence of AD in a melanoma case vs. a healthy control population, demonstrated a significant negative (12) and non-significant positive association (13) between melanoma and AD, but these studies also did not correct for melanoma risk factors, except for a recent Dutch study that corrected for phototype (14). To the best of our knowledge, none of the studies conducted on atopy and melanoma investigated the association between atopy and melanoma survival or progression.…”

Section: Inverse Association Between Atopy and Melanoma: A Case-contrmentioning

confidence: 97%

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Inverse Association Between Atopy and Melanoma: A Case-control Study

Marasigan¹,

Morren²,

Lambert³

et al. 2017

Acta Derm Venerol

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Heightened cutaneous immune surveillance in atopic patients may inhibit development of melanoma. The aim of this study was to analyse the association between atopy and melanoma (development and outcome). A total of 188 cases of melanoma and 596 healthy controls were interviewed by telephone with a standardized questionnaire on atopic, demographic and melanoma characteristics. Cases were matched with controls on important confounders (age, sex, sunburn sensitivity, hair colour, number of moles, sunburn as juvenile, ever solarium, familial melanoma). Melanoma outcome data (disease relapse and death) within cases were retrieved. Analysis showed a general inverse association between atopy and melanoma development, but this was statistically significant only for a history of personal atopy (odds ratio 0.53, 95% confidence interval: 0.30-0.96, p-value = 0.04). Among melanoma patients, atopy did not affect survival or progression. In conclusion, this study suggests an inverse association between a history of atopy and melanoma development, but not with disease progression.

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Section: Discussionsupporting

confidence: 89%

Section: Inverse Association Between Atopy and Melanoma: A Case-contrmentioning

confidence: 97%

Inverse Association Between Atopy and Melanoma: A Case-control Study

Marasigan¹,

Morren²,

Lambert³

et al. 2017

Acta Derm Venerol

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“…In addition, other studies have not reported an increased risk of malignant melanoma (SIR 0AE6; 95% CI 0AE3-1AE2). 16 Likewise, in a hospital-based case-control study on melanoma and atopy 29 it was reported that three subjects had pure eczema among 331 melanoma cases vs. 11 with eczema (seven pure eczema, three with eczema and rhinitis, and one with eczema, rhinitis and asthma) among 380 controls. The possible under-reporting of NMSC common to databases does not extrapolate to melanoma and the diagnosis of melanoma in THIN is sufficiently accurate for research.…”

Section: Discussionmentioning

confidence: 99%

Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K.

Arana¹,

Wentworth²,

Fernández-Vidaurre

et al. 2010

British Journal of Dermatology

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“…While the skin is a primary target organ for allergic pathology [ e.g ., atopic dermatitis (AD), eczema], little literature exists assessing the relationship of allergy and allergy biomarkers to skin cancers. The association of allergy to melanoma is equivocal: one study suggested marked reduction in melanoma in asthma patients in a health registry dataset (4), another cohort study indicated an increased melanoma risk in male hayfever patients (8), and a case-control study found a marked reduction in risk (5). Non-melanoma skin cancers were examined far less, possibly due to their lack of capture in most central cancer registries; results have been mixed.…”

Section: Discussionmentioning

confidence: 99%

Risk of Squamous Cell Carcinoma of the Skin in Relation to IgE: a Nested Case–Control Study

Wiencke

Nelson

2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Individuals diagnosed with non-melanoma skin cancer have a high risk of developing a second skin cancer diagnosis. We assessed whether a marker of immune function related to atopic allergy, IgE, was associated with diagnosis of subsequent squamous cell carcinoma (SCC) of the skin in patients with a previous skin cancer enrolled in a skin cancer prevention trial. Methods One hundred twelve cases with a repeat skin cancer diagnosis were compared to 227 controls, matched on age, sex, and study center. Total, respiratory, and food-specific IgE were measured in the baseline or year one (prior to diagnosis) sera samples for each subject. Results IgE levels were higher in cases with a second SCC than controls (comparing the highest quartile to the lowest, ORtotal IgE=1.44; 95% CI:0.73–2.85; ORrespiratory IgE =2.43; 95% CI:1.16–5.06; ORfood IgE =2.53; 95%CI:1.19–5.35). The association between respiratory IgE and subsequent skin cancer was strongest among individuals with a tendency to sunburn (ORrespiratory IgE =3.82; 95%CI: 1.05–13.88) compared with those with a tendency to tan (ORrespiratory IgE = 0.95; 95%CI:0.20–4.76). Among 25 subjects with repeat IgE measurements taken over several years, IgE levels were remarkably stable (interclass coefficient = 0.90 for total IgE). Conclusions These results indicate that allergy or allergy-associated IgE may be indicative of an immune phenotype that enhances risk of SCC, possibly via immune-associate inflammatory mediators. Impact Our results indicate that controlling allergy and IgE levels may be a new avenue of skin cancer prevention in susceptible populations, and implicate immune mechanisms in skin carcinogenesis.

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Melanom und Atopie

Cited by 17 publications

References 0 publications

Inverse Association Between Atopy and Melanoma: A Case-control Study

Inverse Association Between Atopy and Melanoma: A Case-control Study

Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K.

Risk of Squamous Cell Carcinoma of the Skin in Relation to IgE: a Nested Case–Control Study

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