Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K.

Arana, Alejandro; Wentworth, Charles; Fernández-Vidaurre, Carlos; Schlienger, Raymond G.; Conde, Eulogio; Arellano, Félix

doi:10.1111/j.1365-2133.2010.09887.x

Cited by 84 publications

(109 citation statements)

References 28 publications

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“…The latter study also showed a reduced risk of multiple myeloma in asthmatic women (SIR = 0.53). A significant inverse association between asthma and leukemia was also reported by Turner et al [12] (RR = 0.75), whereas two further studies showed a positive association between lymphoma and atopic dermatitis; one calculated an SIR of 2.0 whilst the other presented an IRR of 2.21 [20,21]. In a further study, where hematological malignancy was not specified, allergic rhinitis turned out to be a risk factor too (SIR = 1.23) [15].…”

Section: Resultsmentioning

confidence: 74%

“…They found a slightly increased risk of cancer for asthmatic men (SIR = 1.12), whereas González-Pérez et al [18] reported no association. A positive association between atopic dermatitis and cancer risk was observed in a prospective study in Denmark (SMR = 1.5) as well as in a retrospective cohort study in Sweden observing 15,666 patients hospitalized for atopic dermatitis (SIR = 1.13), and a study in the UK (IRR = 1.49) [19,20,21]. Three further studies could not describe any correlation between a history of allergy and either cancer in general or any specific cancer site [22,23,24].…”

Section: Resultsmentioning

confidence: 99%

“…Among 6,275 hospitalized atopic dermatitis patients, not a single case of malignant melanoma was found [19]. Another study involving patients with atopic dermatitis found an increased risk of melanoma as well as of nonmelanoma skin cancer [21]. …”

Section: Resultsmentioning

confidence: 99%

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Relationship between Allergy and Cancer: An Overview

Rittmeyer

Lorentz²

2012

Int Arch Allergy Immunol

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Allergic diseases and malignancies cause a lot of morbidity, mortality and high costs for healthcare systems. An inverse association between allergy and cancer has been suspected for a long time, but even despite extensive research no general relationship has been determined. This review comprises 32 epidemiological studies published between 1960 and 2011 and draws conclusions regarding relationships between specific types of cancer and allergic diseases. On the one hand, inflammatory reactions in the course of allergy can support carcinogenesis but are limited to specific areas, whereas on the other hand systemic effects in terms of enhanced immunosurveillance can prevent cancer.

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Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%

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Relationship between Allergy and Cancer: An Overview

Rittmeyer

Lorentz²

2012

Int Arch Allergy Immunol

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“…Legendre et al (2015) performed a meta-analysis of 4 cohort studies and 18 case-control studies, and found a modest increase in risk of lymphoma in patients with AD compared with the general population (43). The increased risk was statistically significant in the meta-analysis of the cohort studies (RR 1.43, 95% CI, 1.12 -1.81) (24,(44)(45)(46). In the meta-analysis of the case-control studies the increased risk for lymphomas was insignificant (OR 1.18, 95% CI 0.94 -1.47) (43).…”

Section: Atopic Dermatitis Per Se and Increased Risk For Lymphomamentioning

confidence: 99%

Topical Calcineurin Inhibitors and Malignancy Risk

et al. 2017

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Context: The approval of topical calcineurin inhibitors (TCIs) has been a significant breakthrough for the treatment of atopic dermatitis due to much lower systemic absorption and not causing skin atrophy even after long-term use that have made them become popular replacements for topical corticosteroids being almost equally effective. In January 2006, the US food and drug administration (FDA), followed later also by the European medicine agency (EMEA), issued the "black box" warning causing controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis and treated with TCIs. Evidence Acquisition: PubMed and MEDLINE ® databases were systematically searched utilizing a variety of terms relating to the subject matter. Articles written only in English over the past 15 years were analyzed and selected for review. Results: So far, no scientific evidence of the association has been found between use of TCIs, and increased incidence of skin cancers and lymphomas in patients with AD. The systematic review and meta-analysis by Legendre et al. found the role of TCIs unlikely to be a significant risk factor of lymphoma in those patients. Conclusions:Despite an extensive body of evidence regarding the TCIs safety, the box warning still remains leaving the physicians and patients unduly uncertain and confused about the safety of TCI use.

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“…− The second one proposes a relation between atopy and an increased risk of neoplastic diseases, stemming from chronic stimulation of the immunological system [1,2,3]. According to the first hypothesis, the overstimulation of immunocompetent cells, which results from contact with an allergen, causes the production of certain IgE antibodies that may have a cytotoxic influence on neoplastic cells.…”

Section: Introductionmentioning

confidence: 99%

The link between neoplastic and atopic diseases

Kozłowska

Bożek

Jarząb

2017

Ann. Acad. Med. Siles.

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WstępOchronny lub stymulujący wpływ atopii na ryzyko rozwoju nowotworu pozostaje otwartym pytaniem. Dotychczasowe prace naukowe analizujące temat przynoszą różne odpowiedzi. W pracy badano występowanie chorób nowotworowych u pacjentów z potwierdzonymi chorobami atopowymi w stosunku do grupy kontrolnej bez cech atopii.Materiał i metodyU 1451 pacjentów z chorobą atopową oraz 1389 osób stanowiących grupę kontrolną w wieku powyżej 35 r.ż. wykonano badanie, alergiczne testy skórne, oznaczono stężenie alergenowo swoistych przeciwciał IgE przeciwko najczęstszym alergenom wziewnym. Przeprowadzono analizę dokumentacji medycznej oraz wypełniono oryginalny kwestionariusz zawierający między innymi pytania o ewentualne występowanie chorób nowotworowych i alergii u pacjenta oraz w jego rodzinie. Dodatkowo wykonano oznaczenia następujących markerów nowotworowych w surowicy krwi AFP, CEA, SCC, PSA, Ca 15.3, Ca 19-9, Ca 125, HCG, CYFRA 21-1.WynikiWyniki potwierdziły brak istotnej różnicy w częstości występowania większości analizowanych nowotworów pomiędzy badanymi grupami. Odnotowano znacznie mniejszą zachorowalność na przewlekłą białaczkę szpikową oraz przewlekłą białaczkę limfatyczną w grupie badanej. Zaobserwowano ujemną korelację pomiędzy wartością stężenia całkowitej IgE w surowicy krwi a prawdopodobieństwem rozpoznania choroby nowotworowej w grupie badanej. Wśród pacjentów z chorobą atopową obserwowano wyższe stężenie markeru CYFRA 21-1 w surowicy krwi, lecz bez manifestacji klinicznej.WnioskiWystępowanie choroby nowotworowej jest nieznacznie niższe u pacjentów z chorobami atopowymi niż w grupie kontrolnej bez alergii. Nie odnotowano istotnych różnic w analizowanych markerach nowotworowych surowicy krwi pomiędzy grupami.

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Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K.

Abstract: Our results indicate an increased incidence of cancer overall as well as of specific cancer subtypes, including lymphoma, in patients with AD. Further studies are needed to disentangle the effects of treatment for AD from AD itself.

Cited by 84 publications

References 28 publications

Relationship between Allergy and Cancer: An Overview

Relationship between Allergy and Cancer: An Overview

Topical Calcineurin Inhibitors and Malignancy Risk

The link between neoplastic and atopic diseases

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