Melanogenesis‐Inhibitory and Antioxidant Activities of Phenolics from <i>Periploca forrestii</i>

Sun, Cai-Ling; Chen, Lei; Xu, Jian; Qu, Wei; Guan, Li; Liu, Wenyuan; Akihisa, Toshihiro; Feng, Feng; Zhang, Jie

doi:10.1002/cbdv.201700083

Cited by 13 publications

(18 citation statements)

References 40 publications

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“…Furthermore, we have evaluated the crude extracts and isolated compounds for their oxidation resistance ability as well as melanogenesis inhibitory activity, which is considered to be related with the former . In addition, we also choose compound 8 to evaluate the inhibitory activity of tyrosinase which plays an important role in regulating melanin formation …”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities

Zhu

Wang

et al. 2018

Chemistry & Biodiversity

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There is a growing interest in the exploitation of agricultural byproducts. This study explored the potential beneficial health effects from the main biowaste, tea seed pomace of Camellia oleifera Abel (Theaceae), produced when tea seed is processed. Eighteen compounds were isolated from the 70% EtOH extract of the seed cake of C. oleifera. Their structures were determined by ESI-MS, H- and C-NMR together with literature data. All fractions and compounds were evaluated for the antioxidant and melanogenesis inhibitory activities. As the result, AcOEt fraction has the best in vitro antioxidant and antimelanogenesis activities, compounds 7 - 12 and 15 showed remarkable antioxidant activity, compounds 4, 6, 8, and 15 - 17 exhibited superior inhibitory activities against melanogenesis. Furthermore, tyrosinase inhibitory activity assay suggested that compound 8 could suppress melanogenesis by inhibiting the expression of tyrosinase.

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Section: Introductionmentioning

confidence: 99%

Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities

Zhu

Wang

et al. 2018

Chemistry & Biodiversity

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“…Meanwhile, compounds 1 – 7 also displayed high scavenging effect in the range of 0.87 – 8.43 μ m Trolox /μ m by ABTS assay, as well as exhibited moderate – higher ferric reducing power in the range of 1.01 – 5.79 μ m Fe 2+ /μ m by FRAP assay. It was the similar trend on DPPH and ABTS assays, which is due to compounds 1 – 7 possess the multiple phenolic OH groups leading to increase of the H‐radical‐donating activity . In addition, in the structure–activity relationship research of these compounds, it illustrated that compounds 3 and 4 showed more potent antioxidant activities than other compounds, because more phenolic OH groups can increased the antioxidant activities.…”

Section: Resultsmentioning

confidence: 56%

“…Melanogenesis‐inhibition assay in the α ‐MSH‐stimulated B16 melanoma cells was performed as described previously …”

Section: Methodsmentioning

confidence: 99%

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Biological Activities of Phenolics from the Fruits of Phyllanthus emblica L. (Euphorbiaceae)

Zhang

Miao

Zhu

et al. 2017

Chemistry & Biodiversity

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Seven phenolic compounds, 1 - 7, including a new organic acid gallate, mucic acid 1-ethyl 6-methyl ester 2-O-gallate (7), were isolated from the MeOH extract of the fruits of Phyllanthus emblica L. (Euphorbiaceae). The structures were elucidated on the basis of extensive spectroscopic analysis and comparison with literature data. Upon evaluated for their antioxidant abilities by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), and ferric reducing antioxidant power (FRAP) assays. The inhibitory activities against melanogenesis in B16 melanoma cells induced by α-MSH, as well as cytotoxic activities against four human cancer cell lines were also evaluated. All phenolic compounds, 1 - 7, exhibited potent antioxidant abilities (DPPH: IC 5.6 - 12.9 μm; ABTS: 0.87 - 8.43 μm Trolox/μm; FRAP: 1.01 - 5.79 μm Fe /μm, respectively). Besides, 5 - 7, also exhibited moderate inhibitory activities against melanogenesis (80.7 - 86.8% melanin content), even with no or low toxicity to the cells (93.5 - 101.6% cell viability) at a high concentration of 100 μm. Compounds 1 - 3 exhibited cytotoxic activity against one or more cell lines (IC 13.9 - 68.4%), and compound 1 with high tumor selectivity for A549 (SI 3.2).

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“…Several in vivo and in vitro studies of P. forrestii or P. forrestii-containing Chinese medicine have also focused on delineating their effects on antiarthritis activities [ 24 – 26 ]. In addition, P. forrestii also exert an anti-inflammatory effect, antiallergy activities, and antioxidant activities [ 27 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation

Zeng

Liu

Xing

et al. 2020

Mediators of Inflammation

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Atopic dermatitis (AD) is a relapsing, acute, and chronic skin disease featured by intractable itching, eczematous skin. Conventional therapies based on immunosuppression such as corticosteroids are associated with multiple adverse reactions. Periploca forrestii Schltr saponin (PFS) was shown to potently inhibit murine arthritis by protecting bone and cartilage injury and suppressing NF-κB activation. However, its therapeutic effect on oxazolone-induced atopic dermatitis (AD) and the underlying mechanisms on macrophage are still unclear. The AD-like dermatitis was induced by repeated oxazolone challenge to the skin of BALB/c mice in vivo. Blood and ears were biochemically or histologically processed. RT-PCR, western blotting, and ELISA were conducted to evaluate the expression of macrophage factors. Mouse bone marrow-derived macrophages (BMDMs) stimulated with lipopolysaccharide (LPS) were used as a model in vitro. PFS treatment inhibited AD-like dermatitis development. PFS downregulated epidermis thickness and cell infiltration, with histological analysis of the skin lesion. PFS alleviated plasma immunoglobulin (Ig) E, IgG2a, and IgG1 levels. PFS downregulated the expression of M1 macrophage factors, tumor necrosis factor- (TNF-) α, interleukin- (IL-) 6, monocyte chemotactic protein-1 (MCP-1), and nitric oxide synthase2 (NOS2), and M2 macrophage factors, IL-4, arginase1 (Arg1) and CD163 in AD-like skin, which were confirmed by western blot and ELISA analysis. In addition, PFS inhibited LPS-induced macrophage polarization via the inhibition of the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and nuclear translocation of NF-κB p65. These results suggest that PFS exerted an antidermatitis effect against oxazolone by modulating macrophage activation. PFS administration might be useful in the treatment of AD and inflammatory skin diseases.

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Melanogenesis‐Inhibitory and Antioxidant Activities of Phenolics from Periploca forrestii

Cited by 13 publications

References 40 publications

Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities

Chemical Constituents of the Seed Cake of Camellia oleifera and Their Antioxidant and Antimelanogenic Activities

Biological Activities of Phenolics from the Fruits of Phyllanthus emblica L. (Euphorbiaceae)

Saponin from Periploca forrestii Schltr Mitigates Oxazolone-Induced Atopic Dermatitis via Modulating Macrophage Activation

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