Melanogenesis Inhibitory Activity of Rhododendron Weyrichii in Mouse B16 Melanoma Cells.

Abstract

In this study, to evaluate the usefulness of Rhododendron weyrichii Maxim. as a whitening agent, the whitening effects of its extracts were investigated in alpha-melanocyte-stimulating hormone (a-MSH)-induced B16F10 melanoma cells. No toxicity was noted in either B16F10 melanoma cells or HaCaT keratinocyte cells that were exposed to the hot water or 70% ethanol extracts of R. weyrichii Maxim. (RW-H and RW-E, respectively). Moreover, both the RW-H and RW-E extracts dose-dependently inhibited a-MSH-induced melanin production in B16F10 melanoma cells, with inhibitory effects of 52.5% and 51.6%, respectively, at a concentration of 200 µg/mL. The RW-H and RW-E extracts also inhibited intracellular tyrosinase activity in a dose-dependent fashion. Western blot analyses showed that the RW-H and RW-E extracts decreased tyrosinase, tyrosinase-related protein-1, and tyrosinase-related protein-2 expression. Additionally, we found that ñ-coumaric acidcontaining RW-H and RW-E extracts could be used as hypopigmentation agents since they suppress melanogenesis. Collectively, our results suggest that RW-H and RW-E extracts have the potential to serve as functional cosmetic agents, including whitening agents.

Gastrodin alleviates angiotensin Ⅱ-induced hypertension and myocardial apoptosis and PRDX2/p53 pathway activation

“…Gastrodia elata BI. has been used in many physicians to treat cerebrovascular and cardiovascular diseases, such as stroke, migraine, cardiac hypertrophy, fibrosis and hypertension 19,[33][34][35][36] . In addition, gastrodin is one of the practical components of Gastrodia elata BI., which has attracted great interest in the research of anti-cardiac injury.…”

Anti-oxidant and Anti-inflammatory Effects of the Fermented Rhododendron weyrichii Flower Extracts in Shindari, a Traditional Jeju Fermented Drink

“…Recently, our group reported that the leaf extract of R. weyrichii can be used as a skin-whitening agent as the extract suppresses melanogenesis [9]. Additionally, the flower extracts mitigated the UVB-induced inflammation in human keratinocytes [10].…”

PHYTOCHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITIES OF CRUDE EXTRACT FROM FLOWERS AND LEAVES OF Rhododendron arboreum Sm. FROM NORTHERN THAILAND

“…Rhododenron arboreum extracts have high antioxidant potential such as anti-aging, antiinflammatory, anti-tyrosinase, hypolipidemic, UV protection, and moisturizing properties when used in cosmetic products (Swamidasan et al, 2008;Tigari et al, 2008;Verma et al, 2011;Thangaraj, 2013;Kim et al, 2016). These bioactive properties are involved with various components such as flavonoids, tannins, essential oils, chromones (isomers of coumarins), terpenoids, and steroids (Krishna et al, 2014).…”