Melanocytoma of the Optic Nerve Head, Thirty-Month Follow-Up

Eldaly, Hasan; Eldaly, Zeiad H

doi:10.3109/08820538.2013.874485

Cited by 10 publications

(22 citation statements)

References 11 publications

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“…The SD-OCT findings of melanoma and nevus we observed were consistent with previous large series [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. The heavily pigmented Type 1 optic disc melanocytoma is usually distinguishable from choroidal melanoma and choroidal nevus by funduscopic findings, but SD-OCT may help confirm the diagnosis and identify associated features, such as subretinal fluid, that could affect the clinical course.…”

Section: Discussionsupporting

confidence: 81%

“…These are summarized in Table 3[5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. Our cases corroborate a constellation of findings that have previously been reported and that are typical of most heavily pigmented optic disc melanocytomas: a very prominent and dense optical shadowing by the heavily pigmented tumor; a sharply demarcated interface between the tumor and a thin, hyperreflective layer of the disorganized overlying retina, and hyperreflective dots accumulated at the tumor-retina interface.…”

Section: Discussionmentioning

confidence: 99%

“…The SD-OCT features of choroidal melanoma and nevus have been well described [1,2,3,4]. While a number of case reports and small case series include limited descriptions of the corresponding features of the classic, darkly pigmented optic disc melanocytoma, these have not included the uncommon, more lightly pigmented form of the tumor [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. We compared the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions

Apinyawasisuk

McCannel²,

Arnold³

2016

Ocul Oncol Pathol

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Aims: The aim of this paper was to compare the features of both the classic, darkly pigmented and the atypical, more lightly pigmented optic disc melanocytoma with those of pigmented choroidal lesions. Methods: We analyzed the spectral-domain optical coherence tomography (SD-OCT) features of 9 eyes with optic disc melanocytoma and compared them with those of choroidal melanoma and nevus. Results and Conclusion: We identified 2 categories of SD-OCT findings in optic disc melanocytoma: (a) type 1, the typical, prominent, hyperpigmented lesion with SD-OCT findings of a hyperreflective, disorganized overlying retina and a posterior hyporeflective shadow, and (b) the less common, atypical, minimally pigmented type 2 lesion overlaid by a relatively well-organized retina that lacks a posterior hyporeflective shadow. Choroidal lesions were characterized by tumor confined beneath the clearly visible hyperreflective line of the photoreceptor and retinal pigment epithelium, with minimal disorganization of the overlying retina.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions

Apinyawasisuk

McCannel²,

Arnold³

2016

Ocul Oncol Pathol

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“…ODMC patients were often asymptomatic and had good vision, but it was difficult to differentiate ODMC from early optic disc melanoma in morphology [ 28 ]. As there can be considerable morbidity associated with excisional biopsy or plaque radiotherapy for the treatment of melanoma of the optic disc, and the observation of lesions was associated with a risk for metastatic disease, developing a non-invasive method facilitating the prediction of tumor behavior was highly desirable.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography characteristics of optic disc melanocytoma

Zhou

Wei

2020

BMC Ophthalmol

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Background Optic disc melanocytoma (ODMC) was a benign pigmented intraocular tumor with the rare potential malignant transformation. This study was designed to evaluate tumor vasculature with optical coherence tomography angiography (OCTA) in ODMC. Methods Eyes of healthy individuals in a control group and of patients with ODMC were imaged by OCTA systems operating at 840 nm wavelengths and examined. The main outcome measures were OCTA images, qualitative evaluation of optic disc and tumor vasculature, quantitative vascular density (VD) and perfusion density (PD). Results One eye of ten normal volunteers and ten patients with ODMC were imaged. Eyes affected by ODMC as compared to the eyes of the control group (all P < 0.05). The healthy optic disc had radially-oriented vessels within the retina on OCTA. Optic disc melanocytoma was characterized by globular, demonstrated tortuous blood vessels, uneven thickness, and relatively disorganized intratumoral vasculature. The VD and PD within ODMC were significantly higher (12.360% ± 4.175, 0.316% ± 0.119%, P < 0.0001) than in normal optic discs (4.160% ± 2.290, 0.102% ± 0.0, 56%, P < 0.0001). No significant differences were established of the VD and PD in each single measurement zone (P > 0.05) between the ODMC and the control eyes. At 840 nm, OCTA could provide sufficient visualization of the tumor vasculature and better penetration through thicker tumors. The full thickness was visualized even in thicker tumors and highly pigmented lesions (> 2 mm). Interpretable OCTA images were obtained in 96% of the participants in whom imaging was attempted. Conclusions OCTA may provide a noninvasive, safe, and efficient technique for evaluating a variety of neoplasms including the growth and vascularity in ODMC. OCTA could facilitate the evaluation of the vascular abnormalities of tumors and the effect of melanin on the penetration of the OCTA beam was not significant.

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“…Despite being a benign lesion, its counterpart, melanoma, is a fatal condition. Malignant melanocytoma is rare; however, it has been documented in 1 to 2% of cases 2,10,12,14,15,17,[19][20][21][22][23][24][25] .…”

Section: Epidemiologymentioning

confidence: 99%

Optic nerve melanocytoma: pathophysiology, clinical considerations, and diagnostic novelties

Estrada-Villarreal¹

2020

RMOE

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Melanocytoma of the Optic Nerve Head, Thirty-Month Follow-Up

Abstract: ONH melanocytoma is a benign tumor with rare malignant transformation and visual impairment.

Cited by 10 publications

References 11 publications

Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions

Clinical and Spectral-Domain Optical Coherence Tomography Appearance of Optic Disc Melanocytoma: A New Classification and Differentiation from Pigmented Choroidal Lesions

Optical coherence tomography angiography characteristics of optic disc melanocytoma

Optic nerve melanocytoma: pathophysiology, clinical considerations, and diagnostic novelties

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