Melanocyte colonization of an oral carcinoma

Modica, Louis A.; Youngberg, George A.; Avila, F.O.

doi:10.1111/j.1365-2559.1990.tb00775.x

Cited by 16 publications

(18 citation statements)

References 5 publications

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“…Among malignant neoplasms of the oral mucosa, SCC is the most common histopathologic type and usually consists of a pure neoplastic keratinocytes without pigmentation (1). Although it has been stated that melanocyte colonization is a well‐recognized occurrence in a variety of tumors of the epidermis and the hair follicles, it is very rare in oral carcinomas (2, 3) We described here a case of pigmented SCC of the hard palate, and review the clinicopathological characteristics of the eight reported cases – including the present case of pigmented SCC in the oral mucosa (4–8). The mean age of patients was 71.8 years, with a range of 47–81 years.…”

Section: Commentsmentioning

confidence: 92%

Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Satomura¹,

Tokuyama²,

Yamasaki³

et al. 2007

J Oral Pathology Medicine

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We present here the clinical, morphological and immunohistochemical features of a pigmented squamous cell carcinoma (SCC) in the oral mucosa of the hard palate of a 76-year-old Japanese man. He underwent a partial resection of the maxilla subsequent to radiotherapy. The tumor was typical, moderately well-differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem cell factor (SCF) and endothelin-1, both of which are known to stimulate proliferation and differentiation of melanocytes, revealed prominent expression of both factors in the neoplastic squamous cells of the pigmented SCC, while the non-pigmented oral SCC showed little sign of either factor. These findings strongly suggest that SCF and endothelin-1 secreted by neoplasmic squamous cells are involved in the emergence of a rare variant of oral SCC.

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Section: Commentsmentioning

confidence: 92%

Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Satomura¹,

Tokuyama²,

Yamasaki³

et al. 2007

J Oral Pathology Medicine

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“…This type of SCC may be difficult to distinguish from cutaneous melanoma. To our knowledge, only 13 cases of pigmented SCC have been reported in the English language literature, with most frequent development in the oral cavity or conjunctiva 1 –11 . However, no case of scrotal pigmented SCC has been reported.…”

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confidence: 99%

Pigmented squamous cell carcinoma of the scrotum associated with a lentigo

Matsumoto¹,

Shinmoto²,

Takeuchi³

et al. 1999

Br J Dermatol

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Only 13 cases of pigmented squamous cell carcinoma (SCC) have been reported in the English language literature, with most frequent development in the oral cavity and conjunctiva. However, no case of pigmented SCC of the scrotum has been reported. We report here a case of pigmented SCC that arose primarily in the scrotum of a 70-year-old man. Light microscopically, this tumour exhibited the typical features of a pigmented SCC, including not only keratinization and intercellular bridges but also colonization by plump dendritic melanocytes with marked pigmentation. These features were clearly confirmed by immunohistochemistry, including strong positivity of tumour cells for high-molecular-weight cytokeratin and of colonizing melanocytes for HMB-45. The tumour was associated with a lentiginous lesion and partly involved it. Melanocytes entrapped from the lentigo might therefore have been activated during enlargement of this tumour, resulting in melanocyte colonization. Fourteen cases of pigmented SCC, including ours, are clinicopathologically reviewed.

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“…The biological behavior of pigmented SCC is also unclear because the number of reported cases are too small. Previous reports have not mentioned the biological aspect of pigmented SCC 3–18 . Further studies on the biological characteristics of pigmented SCC remain to be performed.…”

Section: Discussionmentioning

confidence: 93%

“…In the present case, it is suggested that non‐neoplasmic melanocytes were stimulated, proliferated and migrated in the process of carcinoma cell proliferation, thus leading to pigmented SCC. Authors of previous reports of pigmented SCC had also suggested that the melanocytes in pigmented SCC were not neoplastic 4–19 . Jauregui and Klintworth 4 have suggested that cancer cells produce unknown factors that promote melanocyte proliferation and colonization.…”

Section: Discussionmentioning

confidence: 99%

“…Squamous cell carcinoma (SCC) of the skin and mucosa may show various unusual histologies such as acantholytic, mucin-producing, spindle cell, 1 verrucous, clear cell 2 and pigmented SCC, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] in addition to conventional SCC and Bowen's disease. These variants of SCC, except for verrucous, usually develop in sun-exposed skin either de novo or in association with a solar keratosis.…”

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confidence: 99%

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Pigmented squamous cell carcinoma of the cheek skin probably arising from solar keratosis

Terada

Yamagami

Fugimoto

et al. 2003

Pathology International

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We report a rare case of pigmented squamous cell carcinoma (SCC) of the cheek skin probably arising from solar keratosis. An 80-year-old man was referred to our clinic because of a black skin nodule in the right cheek. The nodular lesion was 1 cm in diameter, dome-shaped, hard, sharply demarcated, partially erosive and telangiectatic at the border. The lesion was completely excised under the clinical diagnosis of probable seborrheic keratosis. Microscopically, cutaneous horn and mildly atypical squamous epithelia suggestive of previous solar keratosis were present in the surface of the lesion. The lesion consisted of atypical squamous cells with keratinization and intercellular bridges, and it was regarded as SCC. The SCC cells were seen to invade lightly into the upper dermis, where lymphocytic infiltrations and melanophages were noted. Characteristically, heavy deposition of melanin pigment was recognized in the SCC cells as well as in proliferated dendritic and pigment blockade melanocytes that were scattered or colonized within the SCC cell nests. Masson-Fontana stain revealed numerous melanin granules in the SCC cells, as well as in dendritic and pigment blockade melanocytes. Immunohistochemically, the SCC cells were positive for cytokeratins and epithelial membrane antigen, and negative for S-100 protein and HMB45 antigen. Dendritic and pigment blockade melanocytes were negative for cytokeratins, epithelial membrane antigen, and HMB45 antigen, but positive for S-100 protein. The present case suggests that SCC cells of the skin may induce proliferation of melanocytes. The differential diagnosis and the histogenesis of pigmented SCC of the skin are discussed.

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Melanocyte colonization of an oral carcinoma

Cited by 16 publications

References 5 publications

Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Possible involvement of stem cell factor and endothelin‐1 in the emergence of pigmented squamous cell carcinoma in oral mucosa

Pigmented squamous cell carcinoma of the scrotum associated with a lentigo

Pigmented squamous cell carcinoma of the cheek skin probably arising from solar keratosis

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