MEIS1 (Meis homeobox 1)

Torres-Flores, Jorge; Lf, Jave-Suarez

doi:10.4267/2042/50194

Cited by 3 publications

(7 citation statements)

References 34 publications

(37 reference statements)

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“…Intriguingly, numerous reports have demonstrated that different molecular modulators are related to MEIS1 expression including TFs, miRNAs, and cellular metabolites (Aksoz et al, ). In addition, MEIS1 can modulate expression of involved genes in cell differentiation and proliferation such as HIF1/2, GATA1, CCND1/3, SOX3, and PBX1 (Torres‐Flores, ). It has been confirmed that MEIS1 is involved in progression of different malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…MEIS1 (myeloid ecotropic viral integration site 1, OMIM: 601739), as an activator for the HOX members, forms heterodimer complex with HOX transcription factors to recruit either transcriptional co‐activator or co‐repressor in a DNA sequence‐dependent manner, modulating expression of target genes. Numerous TFs including PREP1, HOXA7, HOXA9, and CREB1 regulate MEIS1 expression in different normal tissues and several tumor cells (Torres‐Flores, ). MEIS1 has an essential role in regulation of stemness state of stem cells, transcription adjustment of self‐renewal genes, as well as involved genes in cell development and differentiation, playing an oncogenic role in several tumors (Dardaei et al, ; Rad et al, ).…”

Section: Introductionmentioning

confidence: 99%

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MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE‐30

Mahmoudian

Bahadori

Rad

et al. 2019

Molec Gen & Gen Med

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Background MEIS1 (Myeloid ecotropic viral integration site 1), as a homeobox (HOX) transcription factor, has a dual function in different types of cancer. Although numerous roles are proposed for MEIS1 in differentiation, stem cell function, gastrointestinal development and tumorigenesis, the involved molecular mechanisms are poor understood. Our aim in this study was to elucidate the functional correlation between MEIS1 , as regulator of differentiation process, and the involved genes in cell differentiation in human esophageal squamous carcinoma (ESC) cell line KYSE‐30. Methods The KYSE‐30 cells were transduced using recombinant retroviral particles containing specific shRNA sequence against MEIS1 to knockdown MEIS1 gene expression. Following RNA extraction and cDNA synthesis, mRNA expression of MEIS1 and the selected genes including TWIST1, EGF, CDX2, and KRT4 was examined using relative comparative real‐time PCR. Results Retroviral transduction caused a significant underexpression of MEIS1 in GFP‐hMEIS1 compared to control GFP cells approximately 5.5‐fold. While knockdown of MEIS1 expression caused a significant decrease in EGF and TWIST1 mRNA expression, nearly ‐8‐ and ‐12‐fold respectively, it caused a significant increase in mRNA expression of differentiation markers including KRT4 and CDX2 , approximately 34‐ and 1.14‐fold, correspondingly. Conclusion MEIS1 gene silencing in KYSE‐30 cells increased expression of epithelial markers and decreased expression of epithelial‐mesenchymal transition (EMT) marker TWIST1 . It may highlight the role of MEIS1 in differentiation process of KYSE‐30 cells. These results may confirm that MEIS1 silencing promotes differentiation and decreases EMT capability of ESC cell line KYSE‐30.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE‐30

Mahmoudian

Bahadori

Rad

et al. 2019

Molec Gen & Gen Med

View full text Add to dashboard Cite

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“…Protein. Full-length MEIS1 consists of 390 amino acids and has a molecular weight of 43,016 da (6). MEIS1 contains a pre-B-cell leukemia homeobox (PBX)1 interaction domain, serine/threonine-rich domain, aspartic acid/glutamic acid-rich domain, poly-aspartic acid domain, homeodomain and transcriptional activation domain (10).…”

Section: Meis1 and Its Potential As A Cancer Therapeutic Target (Review)mentioning

confidence: 99%

“…MEIS1 is located between LOC729348 and LOC100507073 on chromosome 2p14, and contains the anonymous markers, D2S134 and NIB1519 ( 2 , 6 ). It consists of 13 exons and 137,360 bp ( 6 ).…”

Section: Molecular Biology Of Meis1mentioning

confidence: 99%

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MEIS1 and its potential as a cancer therapeutic target (Review)

Yao

Song

et al. 2021

Int J Mol Med

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Meis homeobox 1 (Meis1) was initially discovered in 1995 as a factor involved in leukemia in an animal model. Subsequently, 2 years later, MEIS1, the human homolog, was cloned in the liver and cerebellum, and was found to be highly expressed in myeloid leukemia cells. The MEIS1 gene, located on chromosome 2p14, encodes a 390-amino acid protein with six domains. The expression of homeobox protein MEIS1 is affected by cell type, age and environmental conditions, as well as the pathological state. Certain types of modifications of MEIS1 and its protein interaction with homeobox or pre-B-cell leukemia homeobox proteins have been described. As a transcription factor, MEIS1 protein is involved in cell proliferation in leukemia and some solid tumors. The present review article discusses the molecular biology, modifications, protein-protein interactions, as well as the role of MEIS1 in cell proliferation of cancer cells and MEIS1 inhibitors. It is suggested by the available literature MEIS1 has potential to become a cancer therapeutic target. Contents 1. Introduction 2. Molecular biology of MEIS1 3. Modification 4. Protein-protein interactions 5. Role of MEIS1 in the proliferation of cancer cells 6. MEIS1 inhibitors 7. conclusions and future perspectives

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Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma

Mahmoudian

Forghanifard

2020

Mol Biol Rep

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MEIS1 (Meis homeobox 1)

Abstract: This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.

Cited by 3 publications

References 34 publications

MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE‐30

MEIS1 knockdown may promote differentiation of esophageal squamous carcinoma cell line KYSE‐30

MEIS1 and its potential as a cancer therapeutic target (Review)

Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma

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