Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma

Mahmoudian, Reihaneh Alsadat; Forghanifard, Mohammad Mahdi

doi:10.1007/s11033-020-05423-5

Cited by 9 publications

(3 citation statements)

References 61 publications

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“…MEIS1 dysregulation may alter the function of the Notch pathway [69,70]. MEIS1 has a close correlation with the stemness state and the Notch signaling pathway involved in SALL4 [71].…”

Section: Sall4 Activates the Notch Signaling Pathwaymentioning

confidence: 99%

SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance

Sun

et al. 2022

IJMS

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SALL4, a member of the SALL family, is an embryonic stem cell regulator involved in self-renewal and pluripotency. Recently, SALL4 overexpression was found in malignant cancers, including lung cancer, hepatocellular carcinoma, breast cancer, gastric cancer, colorectal cancer, osteosarcoma, acute myeloid leukemia, ovarian cancer, and glioma. This review updates recent advances of our knowledge of the biology of SALL4 with a focus on its mechanisms and regulatory functions in tumors and human hematopoiesis. SALL4 overexpression promotes proliferation, development, invasion, and migration in cancers through activation of the Wnt/β-catenin, PI3K/AKT, and Notch signaling pathways; expression of mitochondrial oxidative phosphorylation genes; and inhibition of the expression of the Bcl-2 family, caspase-related proteins, and death receptors. Additionally, SALL4 regulates tumor progression correlated with the immune microenvironment involved in the TNF family and gene expression through epigenetic mechanisms, consequently affecting hematopoiesis. Therefore, SALL4 plays a critical oncogenic role in gene transcription and tumor growth. However, there are still some scientific hypotheses to be tested regarding whether SALL4 is a therapeutic target, such as different tumor microenvironments and drug resistance. Thus, an in-depth understanding and study of the functions and mechanisms of SALL4 in cancer may help develop novel strategies for cancer therapy.

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“…MEIS1 dysregulation may alter the function of the Notch pathway [69,70]. MEIS1 has a close correlation with the stemness state and the Notch signaling pathway involved in SALL4 [71].…”

Section: Sall4 Activates the Notch Signaling Pathwaymentioning

confidence: 99%

SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance

Sun

et al. 2022

IJMS

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“…ZCCHC12 depletion suppresses the growth, migration, and invasion of PTC cells [ 22 ]. Mahmoudian and Forghanifard discovered that correlation between different cell signaling pathway-related genes, including ZCCHC12, may lead to the tumorigenesis of esophageal cancer [ 33 ]. Consistent with these views, our study found that ZCCHC12 was upregulated in PTC cells and the knockdown of ZCCHC12 inhibited PTC cell viability, proliferation, migration, and invasion.…”

Section: Discussionmentioning

confidence: 99%

A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma

et al. 2021

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Papillary thyroid carcinoma (PTC) is the most frequent histological type of differentiated thyroid carcinoma. Long noncoding RNAs (lncRNAs) have been widely reported to play a key role in human malignancies, and PTC is included. This study aimed to find out the functions and mechanism of lncRNA LINC00475 in PTC. LINC00475 was upregulated in PTC cells and was mainly located in the cytoplasm according to reverse-transcription polymerase chain reaction analyses and subcellular fractionation assays. As shown by cell counting kit-8 assays, ethynyl deoxyuridine incorporation assays, wound healing assays, and transwell assays, LINC00475 knockdown suppressed cell viability, proliferation, migration, and invasion. Mechanistically, LINC00475 upregulated the expression of messenger RNA zinc finger CCHC-type containing 12 (ZCCHC12) by binding to miR-376c-3p. ZCCHC12 was a direct target gene of miR-376c-3p in PTC cells. The relationship between miR-376c-3p and LINC00475 (or ZCCHC12) in PTC cells was probed by luciferase reporter assays, RNA pulldown assays, and RNA immunoprecipitation assays. In addition, both mRNA and protein levels of ZCCHC12 were downregulated due to miR-376c-3p overexpression or LINC00475 silencing. ZCCHC12 overexpression partially reversed the suppressive effect of LINC00475 knockdown on malignant behaviors of PTC cells. In conclusion, LINC00475 promotes PTC cell proliferation, migration, and invasion by upregulating ZCCHC12 via the interaction with miR-376c-3p.

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“…Additionally, pairwise correspondence was examined to identify any potential correlations. A notable association was observed between HEY1 and MEIS1 ( P < 0.05) and between SIZN1 and MEIS1 ( P < 0.05) in the initial stages of ESCC (stage I/II) compared with the later stages (III/IV)[ 33 ].…”

Section: Molecular Biology Approachesmentioning

confidence: 99%

Novel milestones for early esophageal carcinoma: From bench to bed

Qi,

Huang,

Jin

2024

World J Gastrointest Oncol

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Esophageal cancer (EC) is the seventh most common cancer worldwide, and esophageal squamous cell carcinoma (ESCC) accounts for the majority of cases of EC. To effectively diagnose and treat ESCC and improve patient prognosis, timely diagnosis in the initial phase of the illness is necessary. This article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of ECs. Molecular biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quantitative polymerase chain reaction (qPCR), high-throughput sequencing technology (next-generation sequencing), and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decision-making basis for the diagnosis, treatment, and prognosis of diseases. The investigation of the microbiome is a swiftly progressing area in human cancer research, and microorganisms with complex functions are potential components of the tumor microenvironment. The intratumoral microbiota was also found to be connected to tumor progression. The application of endoscopy as a crucial technique for the early identification of ESCC has been essential, and with ongoing advancements in technology, endoscopy has continuously improved. With the advancement of artificial intelligence (AI) technology, the utilization of AI in the detection of gastrointestinal tumors has become increasingly prevalent. The implementation of AI can effectively resolve the discrepancies among observers, improve the detection rate, assist in predicting the depth of invasion and differentiation status, guide the pericancerous margins, and aid in a more accurate diagnosis of ESCC.

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Crosstalk between MEIS1 and markers of different cell signaling pathways in esophageal squamous cell carcinoma

Cited by 9 publications

References 61 publications

SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance

SALL4 Oncogenic Function in Cancers: Mechanisms and Therapeutic Relevance

A ceRNA network mediated by LINC00475 in papillary thyroid carcinoma

Novel milestones for early esophageal carcinoma: From bench to bed

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