Meigs’ syndrome with elevated serum cancer antigen 125 levels in a case of ovarian sclerosing stromal tumor

Abstract

SCT is a benign ovarian tumor and complete excision is curative. We also review all 37 cases and discuss possible mechanisms of Meigs' syndrome and elevated serum CA 125 level.

A rare case of sclerosing stromal tumor of ovary with Meigs syndrome presenting with torsion

“…A significant linear correlation between volume of pleural effusion and serum Ca125 values has been demonstrated in both benign and malignant diseases. 2 Similar correlation has been demonstrated between CA125 elevation and volume of ascites in Meigs syndrome.…”

“…Since then 38 cases have been reported, including four with SSTs. 2 We report fifth case of Meigs syndrome associated with SST of the ovary.…”

“…Sclerosing stromal cell tumor is a rare benign tumor of ovarian stroma, first described by Chalvaridjian and Scully (1973), 2 SSTs occur in the second or third decades. 1 The most common presentation includes menstrual irregularity, pelvic pain and non-specific symptoms related to ovarian mass.…”

Sclerosing stromal tumour of ovary

“…13 Similar correlation has been demonstrated between CA125 elevation and volume of ascites in Meigs syndrome. Our patient had a raised level of CA125 of 98 IU/ml with mild ascites and pleural effusion.…”

A case of ovarian fibroma masquerading as a uterine fibroid

“…15,16 Ascites is present in 10-15% of patients with ovarian fibroma, and pleural effusion is present in 1%,especially in cases showing large lesions. 17,18 However, most patients with ovarian fibromas remain asymptomatic, with the tumor often progressing to a large pelvic mass. 18 The immunohistochemical study for CA-125 suggested that serum elevation of CA-125 antigen in patients with Meigs' syndrome is caused by mesothelial expression of CA-125 rather than by fibroma.…”