MEIC Evaluation of Acute Systemic Toxicity

Clemedson, Cecilia; McFarlane-Abdulla, Elisabeth; Andersson, Marianne; Barile, Frank A.; Calleja, Mabel C.; Chesné, Christophe; Clothier, Richard H.; Cottin, M.; Curren, Rodger; Daniel-Szolgay, Erika; Dierickx, Paul J.; Ferro, Margherita; Fiskesjö, Geirid; Garza-Ocañas, Lourdes; Gómez-Lechón, Marı́a José; Gülden, Michael; Isomaa, Boris; Janus, Jeffrey; Judge, Paula; Kahru, Anne; Кемп, Р. Б.; Kerszman, Gustaw; Kristen, U.; Kunimoto, Manabu; Kärenlampi, Sirpa; Lavrijsen, Karel; Lewan, Lillemor; Lilius, Henrik; Ohno, Tadao; Persoone, Guido; Roguet, R.; Romert, Lennart; Sawyer, Thomas W.; Seibert, Hasso; Shrivastava, Ravi; Stammati, Annalaura; Tanaka, Noriho; Torres-Alanís, Oscar; Voss, Jens-Uwe; Wakuri, Shinobu; Walum, Erik; Wang, Xinhai; Zucco, Flavia; Ekwall, Björn

doi:10.1177/026119299602400102.1

Cited by 23 publications

(11 citation statements)

References 20 publications

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“…These two methods have been employed with a number of cell lines to determine 'basal cytotoxicity'. The FAL results for the first 50 Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) chemicals have been analysed within the MEIC scheme, and the data were found to correlate well with data on human lethal toxic potential (36,37).…”

Section: Amden Iii: a Workhop On Progress In Validation And Acceptanmentioning

confidence: 97%

FRAME and the Validation Process

Balls

Clothier

2009

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FRAME's historical involvement in the development of the principles of validation, whereby the reliability and relevance of a procedure are established for a specific purpose, and in the practical application of the process, is summarised, and examples of participation in various validation studies on in vitro tests are reviewed. Emphasis is placed on the need for a parallel invalidation process, and on the role of ATLA as a forum for objective reporting and discussion on all aspects of the validation process.

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Section: Amden Iii: a Workhop On Progress In Validation And Acceptanmentioning

confidence: 97%

FRAME and the Validation Process

Balls

Clothier

2009

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“…She published extensively on in vitro neurotoxicology and on the prevalidation of in vitro methods for toxicity testing, e.g. she is a co-author of the majority of the MEIC publications in ATLA (6)(7)(8)(9)(10)(11)(12).…”

Section: : Hanna Tähti (Finland) -For Work In the Field Of In Vitmentioning

confidence: 99%

“…Fifty reference chemicals were voluntarily tested in more than 60 non-animal assays, by 100 laboratories worldwide. Eight papers featuring the results of the MEIC study were published in ATLA (6)(7)(8)(9)(10)(11)(12)(13). The MEIC results provided convincing evidence that, for the evaluation of acute systemic toxicity of chemicals in humans, animal tests could be replaced by in vitro tests, especially by those tests that use human cell lines (7,11).…”

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confidence: 99%

The Tenth Anniversary of the Björn Ekwall Memorial Foundation

2011

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The Björn Ekwall Memorial Foundation (BEMF) was initiated by the Scandinavian Society for Cell Toxicology in 2001, to honour the memory of Dr Björn Ekwall (1940–2000) and to establish a prize, the Björn Ekwall Memorial Award. The prize is awarded to scientists who have significantly contributed to the field of cell toxicology, and whose work is contributing toward the replacement of animal experiments by alternative toxicity tests. Over the past 10 years, the Björn Ekwall Memorial Award has been presented annually. Björn Ekwall, an outstanding Swedish cell toxicologist, was one of the pioneers in the development and application of alternative methods to animal tests in toxicology. All his scientific work was devoted to in vitro toxicology, and in particular, to the use of cultured human cells for the screening of toxic chemicals. In the middle of the 1980s, he initiated the international Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) project, to evaluate the usefulness of in vitro tests for the estimation of human acute systemic toxicity. To prove his “basal cytotoxicity concept”, he established the MEMO database, in which data on the acutely toxic human blood concentrations of drugs and chemicals were collated from the literature and from clinical studies. He also initiated another project, Evaluation-Guided Development of In Vitro Toxicity and Toxicokinetic Tests (EDIT). The ideas from the EDIT project, together with those from the MEIC project, became the basis for today's international EU projects, e.g. ACuteTox, Sens-it-iv and ReProTect. In this article, 10 years after the start of the BEMF, the scientific achievements of each of the award winners in the field of in vitro toxicology are presented, together with a brief synopsis of their careers.

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“…The results of the MEIC programme have been published as a series of eight papers in ATLA (43)(44)(45)(46)(47)(48)(49)(50).…”

Section: The Meic and Edit Programmesmentioning

confidence: 99%