FRAME and the Validation Process

Balls, Michael; Clothier, Richard H.

doi:10.1177/026119290903700608

Cited by 4 publications

(3 citation statements)

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“…We have recently reviewed the involvement of FRAME and the FAL in test development and in the definition of the principles of validation (the independent establishment of the reliability and relevance of a procedure for a specific purpose) and the practical application of the process (7).…”

Section: Test Development and Validationmentioning

confidence: 99%

“…Within a few months, we had raised sufficient funds from industry to support FRAME's first multi-centre laboratory research project, which led to the development of the Kenacid Blue cytotoxicity test (4), referred to above. We also received the first British Government grant specifically for research on replacement alternatives (5), which enabled us to set up the FRAME Alternative Test Validation Scheme (6,7).…”

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confidence: 99%

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The Development and Evaluation of In Vitro Alternative Assays: A Personal Perspective

Clothier

2010

Altern Lab Anim

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Over the past 30 years, FRAME has actively participated in the development, evaluation and validation of in vitro alternative methods through the FRAME Alternatives Laboratory (FAL) in the University of Nottingham Medical School. Much has been learned through collaboration with industry (especially the cosmetics industry), other organisations (especially ECVAM), and certain individuals (notably Dr Björn Ekwall), particularly in relation to the need to use human cell cultures and to obtain, wherever possible, high-quality human data for use in in vivo/in vitro comparisons. Reference is made to the author's experience as Director of the FAL, notably in the development of in vitro assays for basal cytotoxicity, phototoxicity and the effects of repeated dosage.

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Section: Test Development and Validationmentioning

confidence: 99%

mentioning

confidence: 99%

The Development and Evaluation of In Vitro Alternative Assays: A Personal Perspective

Clothier

2010

Altern Lab Anim

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“…Fourthly, Richard Clothier and I review the historical involvement of FRAME, as a research charity, in the development of the principles of validation -the process whereby the reliability and relevance of a procedure are established for a specific purpose -and summarise FRAME's role in the practical application of the process. 4 Emphasis is also placed on the need for a parallel invalidation process, and on the role of ATLA as a forum for objective reporting and discussion on all aspects of the validation process. FRAME's participation has also involved many collaborations, beginning with the establishment of the FRAME Research Programme and its funding by a consortium of industrial companies in 1982, followed, in 1983, by support from the British Government for one of the first international test validation schemes.…”

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confidence: 99%