Meibomian gland loss due to trabeculectomy

Sagara, Hideto; Sekiryu, Tetsuju; Noji, Hiroki; Ogasawara, M.; Sugano, Yukinori; Horikiri, Hiroko

doi:10.1007/s10384-014-0324-6

Cited by 24 publications

(16 citation statements)

References 38 publications

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“…When analyzing eyelids, though we found a reduction of MGI, we did not observe significant changes in MGD. This is in contrast with the study of Sagara and coworkers, who documented MG loss after MMC augmented trabeculectomy 18 . This could be due to the fact that they considered patients with a longer follow-up and evaluated the upper eyelid, where MGs may be more disturbed by the direct contact with the bleb.…”

Section: Discussioncontrasting

confidence: 95%

“…When filtration surgery is completely successful it may potentially produce significant improvements of the OS system through different mechanisms. Consequently, the positive change of the OS status may produce potential benefits for the patient QoL; however, on the other hand, the presence of a filtering bleb may induce different OS alterations and maintain, at least in part, a mitigated form of OSD 16–18 . These aspects may probably account for the worse QoL experienced by surgically compared to medically treated glaucomatous patients 19 .…”

Section: Introductionmentioning

confidence: 99%

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The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

Agnifili

Brescia

Oddone

et al. 2019

Sci Rep

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We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p < 0.001), and a LDCD, SCNI, MGI, HLA-DR (p < 0.001), OSDI and NEI VFQ-25 scores decrease (p < 0.05). The medical group did not show significant OS modifications, showing LSCM and IC parameters significantly worse compared to the surgical group (p < 0.001). The OSDI score correlated with GCD, MGI, SCNI, LDCD, and HLA-DR (p < 0.001; p < 0.05; p < 0.01). The present study found that the whole OS system objectively improved after completely successful glaucoma filtration surgery. These changes positively affected the OSDI score, but not the NEI VFQ-25 score.

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Section: Discussioncontrasting

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

Agnifili

Brescia

Oddone

et al. 2019

Sci Rep

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“…Although such treatment has been found to adversely affect the structure of meibomian glands, it remains unclear to what extent these effects are attributable to the preservative or the active ingredient of the eyedrops. [50][51][52][53] A study of meibomian glands in glaucoma patients after trabeculectomy with mitomycin C revealed that the glands adjacent to the bleb were damaged compared with those distant from the bleb, 52 suggesting that drug-induced meibomian gland injury occurred through the palpebral conjunctiva.…”

Section: Treatment With Antiglaucoma Eyedropsmentioning

confidence: 99%

Meibography: A Japanese Perspective

Arita

2018

Invest. Ophthalmol. Vis. Sci.

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Meibography allows observation of meibomian glands in an objective and repeatable manner. Original meibography systems were invasive and not readily adopted by ophthalmology clinics. The development of noncontact infrared meibography allowed the rapid and noninvasive observation of meibomian glands, and such systems have now been widely adopted for standard examinations in dry eye clinics. Noncontact meibography has also spurred research into meibomian glands and has been applied to evaluation of their structure and status in various ocular surface diseases. Although the images obtained by meibography are objective and repeatable, the interpretation of these images is subjective, with the relationship between image features and actual gland structure and composition remaining unclear. Additional clinical and basic research with regard to the interpretation of meibography images is thus necessary. Future improvements to meibography will likely provide new insights into the pathophysiology of meibomian gland diseases as well as enhance its contribution to the diagnosis and evaluation of treatments for such diseases.

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“…Some ocular conditions have been reported to influence FVA. Goto et al reported that dry eye decreased FVA among patients who had normal conventional visual acuity [ 8 , 9 ]. FVA is significantly reflected in the tear functions and ocular surface status of the eye.…”

Section: Introductionmentioning

confidence: 99%

Reduction in Ocular Hypotensive Eyedrops by Ab Interno Trabeculotomy Improves Not Only Ocular Surface Condition But Also Quality of Vision

Kashiwagi

Matsubara

2018

Journal of Ophthalmology

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Purpose To investigate the effect of ab interno trabeculotomy using the Trabectome surgical system on tear film stability and functional visual acuity (FVA). Patients and Methods Adult glaucoma patients who underwent Trabectome surgery alone or Trabectome surgery combined with phacoemulsification with intraocular lens insertion were included in this study. Corneal epithelial defects, tear film breakup time (TBUT), tear meniscus height, tear film spreading grade, tear interferometry grade, and FVA were assessed before and after surgery in addition to routine ophthalmic examinations. Changes in ocular surface conditions and visual acuity as a result of the Trabectome surgery were investigated. Results Thirty eyes of 22 patients with a mean age of 72.2 ± 7.9 years, including 8 males and 14 females, were enrolled. The Trabectome surgery significantly reduced the intraocular pressure (IOP) from 20.3 ± 5.2 to 15.0 ± 3.3 mmHg (P < 0.001) and the number of different types of ocular hypotensive eyedrops used from 3.2 ± 0.7 to 1.1 ± 0.7 types (P < 0.001). The surgery significantly improved corneal epithelial defects, the tear spreading grade, the tear interferometry grade, and FVA. The surgery also improved the visual maintenance ratio among all enrolled patients, including those who underwent Trabectome surgery only. Conclusion Trabectome surgery may be beneficial not only for IOP reduction but also for improving ocular surface conditions and FVA.

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Meibomian gland loss due to trabeculectomy

Cited by 24 publications

References 38 publications

The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

Meibography: A Japanese Perspective

Reduction in Ocular Hypotensive Eyedrops by Ab Interno Trabeculotomy Improves Not Only Ocular Surface Condition But Also Quality of Vision

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